IP Library › Granted Patent US 10,450,375
Granted Patent B2
US 10,450,375 · App. 10/980,496 · Granted Oct 22, 2019

Methods of treating sickle cell disease

Inventors: Paul S. Frenette (New York, NY); Barry S. Coller (New York, NY); Aslihan Turhan (New York, NY)
Assignee: Icahn School of Medicine at Mount Sinai
C07K16/2839C07K16/241C07K16/2851A61K2039/505
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Quick Facts
Patent No.
US 10,450,375
App. No.
10/980,496
Granted
Oct 22, 2019
Kind
B2
Abstract

The present invention relates to methods of treating sickle cell disease comprising reducing, in a subject in need of such treatment, the adherence between sickle RBCs and leukocytes. It is based, at least in part, on the discovery that leukocytes play a direct role in the initiation of venular occlusion. The present invention further provides for methods for identifying agents which decrease SS-RBC/leukocyte adherence and for animal models which may be used to further elucidate the mechanism of vaso-occlusion in sickle cell crises.

Claims (1)

1. A method of treating a sickle cell disease subject in vaso-occlusive crisis comprising administering an E-selectin inhibitor that interacts with a calcium-binding lectin domain of E-selectin in an amount effective to treat the subject.

Assignments (1)
CONFIRMATORY LICENSE Recorded Apr 10, 2014
From: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 032652/0011 →
Continuity (3)
Continuation 10123373 · Apr 15, 2002
Provisional Application 60283776 · Apr 13, 2001
Related Publication 20050112124A1 · May 26, 2005
Cited By (1)
US 12,577,308