Alpha-fetoprotein peptides and uses thereof
View Patent ↗The subject invention addresses the need for methods of treatment and prevention of breast cancer, and other cancers, by providing a peptide of eight to twenty amino acids in length which comprises a hydrophilic analog of an alpha-fetoprotein peptide having SEQ ID NO:6: EMTPVNPG. The peptides may be linear, but are preferably cyclic. The peptides may be provided as dimers or other multimers. A composition comprising the peptide, an antibody that specifically binds to the peptide, a method of reducing estrogen-stimulated growth of cells using the peptide, as well as a method of treating or preventing cancer, such as breast cancer, are also provided. The treatment or prevention method can include the use of tamoxifen therapy in combination with the peptide therapy.
1. A method of reducing estrogen-stimulated growth of cells in a subject, the method comprising exposing said cells to a peptide, comprising a sequence selected from the group consisting of:
SEQ ID NO:4:
EMTOVNOG;
SEQ ID NO:5:
EMTOVNOGQ;
SEQ ID NO:8:
EMTOVNPG;
SEQ ID NO:9:
EMTOVNPGQ;
SEQ ID NO:10:
EMTPVNOG; and
SEQ ID NO:11:
EMTPVNOGQ,
and wherein said peptide has antiestrotrophic activity and is eight to twenty amino acids long.
2. The method of claim 1 , comprising exposing the cells to tamoxifen before, during, or after exposing the cells to the peptide.
3. The method of claim 1 , wherein said peptide is a dimeric peptide consisting of two peptides selected from the group consisting of SEQ ID NOS: 4–5, and 8–11.
4. The method of claim 3 , wherein the dimeric peptide consists of SEQ ID NO: 4 and SEQ ID NO: 5.
5. The method of claim 1 , wherein said peptide is a multimeric peptide consisting of three or more peptides selected from the group consisting of SEQ ID NOS: 4–5, and 8–11.