Methods for reducing body fat using vitamin D compounds
View Patent ↗A treatment for obesity and overweight comprises administering a vitamin D analog. The analog effectively inhibits an increase in body fat to animals at risk and decreases the basal fat content of animals. The treatment has a positive effect on the lean body component such that while there is an overall decrease in body weight, there is also a decrease in percent body fat. This decrease can be proportionally greater than the overall decrease in body weight. In addition, the treatment has a positive effect on bone turnover and osteogenesis making the vitamin D analog a beneficial treatment for the symptoms of menopause. Various exemplary embodiments of the treatment use the 2-alkylidene derivatives of vitamin D 3 , such as the 2-alkylidene-19-nor derivatives in both the R and S configurations at carbon-20.
1. A method of treating obesity comprising administering to a patient in need thereof a therapeutically effective amount of a vitamin D compound comprising 2-methylene-19-nor-(20S) 1 α,25 dihydroxyvitamin D 3 .
2. The method of claim 1 , wherein administering to the patient comprises administering to a mammal.
3. The method of claim 1 , wherein administering the vitamin D compound does not reduce the lean body component while reducing body fat of the patient.
4. The method of claim 1 , wherein administering the vitamin D compound comprises administering the vitamin D compound orally, parenterally, transdermally, nasally, rectally, by timed release implant or by therapeutic implant.
5. The method of claim 1 , wherein administering the vitamin D compound comprises administering the vitamin D compound combined with a pharmaceutically acceptable carrier.
6. The method of claim 1 , wherein administering the vitamin D compound comprises administering the vitamin D compound at a dosage of from about 0.001 μg per day to 100 mg per day.
7. The method of claim 6 , wherein administering the vitamin D compound comprises administering the vitamin D compound at a dosage range of from about 0.001 μg per day to 100.0 μg per day.
8. The method of claim 1 , wherein administering the vitamin D compound comprises administering a vitamin D compound having a formula:
9. A method of decreasing the percent body fat of an animal comprising administering to a patient in need thereof a therapeutically effective amount of a vitamin D compound comprising 2-methylene-19-nor(20S) 1α,25 dihydroxyvitamin D 3 having the formula:
10. The method of claim 9 , wherein administering to the patient comprises administering to a mammal.
11. The method of claim 9 , wherein administering the vitamin D compound does not reduce the lean body component of the animal.
12. The method of claim 9 , wherein administering the vitamin D compound comprises administering the vitamin D compound orally, parenterally, nasally, transdermally, rectally, by timed release implant or by therapeutic implant.
13. The method of claim 9 , wherein administering the vitamin D compound comprises administering the vitamin D compound combined with a pharmaceutically acceptable carrier.
14. The method of claim 9 , wherein administering the vitamin D compound comprises administering the vitamin D compound at a dosage of from about 0.001 μg per day to 100 mg day.
15. The method of claim 14 , wherein administering the vitamin D compound comprises administering the vitamin D compound at a dosage range of from about 0.001 μg per day to 100.0 μg per day.
16. A method of inhibiting an increase in body weight comprising administering to a patient in need thereof a therapeutically effective amount of a vitamin D compound comprising 2-methylene-19-nor-(20S) 1α,25 dihydroxyvitamin D 3 .
17. The method of claim 16 , wherein administering to the patient is administering to a mammal.
18. The method of claim 16 , wherein administering the vitamin D compound does not reduce the lean body component of the animal.
19. The method of claim 16 , wherein administering the vitamin D compound comprises administering the vitamin D compound orally, parenterally, nasally, transdermally, rectally, by timed release implant or by therapeutic implant.
20. The method of claim 16 , wherein administering the vitamin D compound comprises administering the vitamin D compound combined with a pharmaceutically acceptable carrier.
21. The method of claim 16 , wherein administering the vitamin D compound comprises administering the vitamin D compound at a dosage of from about 0.001 μg per day to 100 mg day.
22. The method of claim 21 , wherein administering the vitamin D compound comprises administering the vitamin D compound at a dosage range of from about 0.001 μg per day to 100.0 μg per day.
23. The method of claim 16 , wherein administering the vitamin D compound comprises administering a vitamin D compound having a formula:
24. A method of treating the symptoms of menopause, wherein the symptoms of menopause include weight gain and osteoporosis comprising administering to a patient in need thereof a therapeutically effective amount of a vitamin D compound comprising 2-methylene-19-nor-(20S) 1α,25 dihydroxyvitamin D 3 .
25. The method of claim 24 , wherein administering to the patient comprises administering to a mammal.
26. The method of claim 24 , wherein administering the vitamin D compound does not reduce the lean body component while reducing body fat of the patient.
27. The method of claim 24 , wherein administering the vitamin D compound comprises administering the vitamin D compound orally, parenterally, transdermally, nasally, rectally, by timed release implant or by therapeutic implant.
28. The method of claim 24 , wherein administering the vitamin D compound comprises administering the vitamin D compound combined with a pharmaceutically acceptable carrier.
29. The method of claim 24 , wherein administering the vitamin D compound comprises administering the vitamin D compound at a dosage of from about 0.001 μg per day to 100 mg per day.
30. The method of claim 29 , wherein administering the vitamin D compound comprises administering the vitamin D compound at a dosage range of from about 0.001 μg per day to 100.0 μg per day.
31. The method of claim 24 , wherein administering the vitamin D compound comprises administering the vitamin D compound having a formula: