Compositions comprising a SARM ad GnRH agonist or a GnRH antagonist, and methods of use thereof

1 . A composition comprising a gonadotropin releasing hormone agonist, its analog, isomer, metabolite, derivative, pharmaceutically acceptable salt, N-oxide, hydrate, acetate or a combination thereof; and a selective androgen receptor modulator (SARM) compound having in-vivo androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor, said compound represented by the structure of formula I:

wherein:

X is a bond, O, CH 2 , NH, S, Se, PR, NO or NR;

G is O or S;

T is OH, OR, —NHCOCH 3 , or NHCOR;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 ,

CF 2 CF 3 , aryl, phenyl, halogen, alkenyl or OH;

R 1 is CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 ;

R 2 is F, Cl, Br, I, CH 3 , CF 3 , OH, CN, NO 2 , NHCOCH 3 , NHCOCF 3 , NHCOR, alkyl, arylalkyl, OR, NH 2 , NHR, NR 2 , SR;

R 3 is F, Cl, Br, I, CN, NO 2 , COR, COOH, CONHR, CF 3 , SnR 3 , or R 3 together with the benzene ring to which it is attached forms a fused ring system represented by the structure:

Z is NO 2 , CN, COR, COOH, or CONHR;

Y is CF 3 , F, Br, Cl, I, CN, or SnR 3 ;

Q is SCN, NCS, OCN, or NCO;

n is an integer of 1-4;

m is an integer of 1-3; and

wherein all unspecified positions can be substituted or unsubstituted.

2 - 10 . (canceled)

11 . The composition according to claim 1 , wherein G is O, T is OH, R1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q is NCS.

12 - 24 . (canceled)

25 . A composition comprising a gonadotropin releasing hormone agonist, its analog, isomer, metabolite, derivative, pharmaceutically acceptable salt, N-oxide, hydrate, acetate or a combination thereof; and a selective androgen receptor modulator (SARM) compound having in-vivo androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor, said compound represented by the structure of formula II:

Wherein:

X is a bond, O, CH2, NH, S, Se, PR, NO or NR;

G is O or S;

R1 is CH3, CH2F, CHF2, CF3, CH2CH3, or CF2CF3;

T is OH, OR, —NHCOCH3, or NHCOR;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;

A is a ring selected from:

B is a ring selected from:

wherein A and B cannot simultaneously be a benzene ring;

Z is NO2, CN, COOH, COR, NHCOR or CONHR;

Y is CF3, F, I, Br, Cl, CN CR3 or SnR3;

Q1 is NCS, SCN, NCO or OCN;

Q2 is a hydrogen, alkyl, halogen, CF3, CN CR3, SnR3, NR2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCP3, NHCSR NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R, SR,

Q3 and Q4 are independently of each other a hydrogen, alkyl, halogen, CF3, CN CR3, SnR3, NR2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R or SR;

W1 is O NH, NR, NO or S;

W2 is N or NO and

wherein all unspecified positions can be substituted or unsubstituted.

26 - 33 . (canceled)

34 . The composition according to claim 25 , wherein G is O, T is OH, R1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q1 is NCS.

35 - 46 . (canceled)

47 . A composition comprising a gonadotropin releasing hormone agonist, its analog, isomer, metabolite, derivative, pharmaceutically acceptable salt, N-oxide, hydrate, acetate or a combination thereof; and a selective androgen receptor modulator (SARM) compound having in-vivo androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor, said compound represented by the structure of formula III:

wherein

X is a bond, O, CH 2 , NH, S, Se, PR, NO or NR;

G is O or S;

T is OH, OR, —NHCOCH 3 , or NHCOR

Z is NO 2 , CN, COOH, COR, NHCOR or CONHR;

Y is CF 3 , F, I, Br, Cl, CN, CR 3 or SnR 3 ;

Q is NHCOCH 3 , SCN, NCS, OCN, or NCO;

R is alk-yl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 ,

CF 2 CF 3 , aryl, phenyl, halogen, alkenyl or OH; and

R 1 is CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 .

48 .- 55 . (canceled)

56 . The composition according to claim 47 , wherein G is O, T is OH, R is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q is NCS.

57 - 58 . (canceled)

59 . The composition according to claim 47 , represented by the structure of formula IV:

60 - 139 . (canceled)

140 . A method of treating, preventing, suppressing, inhibiting or reducing the incidence of a condition associated with androgen decline in a male subject, wherein said condition is sexual dysfunction, decreased sexual libido, erectile dysfunction, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity or muscle wasting, said method comprising the step of administering to said subject a selective androgen receptor modulator (SARM) and a gonadotropin releasing hormone (GnRH) agonist or antagonist.

141 . The method of claim 140 , wherein said selective androgen receptor modulator (SARM) is represented by the structure of formula I:

wherein:

X is a bond, O, CH 2 , NH, S, Se, PR, NO or NR;

G is O or S;

T is OH, OR, —NHCOCH 3 , or NHCOR;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, halogen, alkenyl or OH;

R 1 is CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 ;

R 2 is F, Cl, Br, I, CH 3 , CF 3 , OH, CN, NO 2 , NHCOCH 3 , NHCOCF 3 , NHCOR, alkyl, arylalkyl, OR, NH 2 , NHR, NR 2 , SR;

R 3 is F, Cl, Br, I, CN, NO 2 , COR, COOH, CONHR, CF 3 , SnR 3 , or R 3 together with the benzene ring to which it is attached foris a fused ring system represented by the structure:

Z is NO 2 , CN, COR, COOH, or CONHR;

Y is CF 3 , F, Br, Cl, I, CN, or SnR 3 ;

Q is SCN, NCS, OCN, or NCO;

n is an integer of 1-4;

m is an integer of 1-3; and

wherein all unspecified positions can be substituted or unsubstituted.

142 - 149 . (canceled)

150 . The method of claim 140 , wherein G is O, T is OH, R1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q is NCS.

151 . The method of claim 140 , wherein said selective androgen receptor modulator (SARM) is represented by the structure of formula II:

Wherein:

X is a bond, O, CH2, NH, S, Se, PR, NO or NR;

G is O or S;

R1 is CH3, CH2F, CHF2, CF3, CH2CH3, or CF2CF3;

T is OH, OR, —NHCOCH3, or NHCOR;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;

A is a ring selected from:

B is a ring selected from:

wherein A and B cannot simultaneously be a benzene ring;

Z is NO2, CN, COOH, COR, NHCOR or CONHR;

Y is CF3, F, I, Br, Cl, CN CR3 or SnR3;

Q1 is NCS, SCN, NCO or OCN;

Q2 is a hydrogen, alkyl, halogen, CF3, CN CR3, SnR3, NR2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R, SR,

Q3 and Q4 are independently of each other a hydrogen, alkyl, halogen, CF3, CN CR3, SnR3, NR2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R or SR;

W1 is O, NH, NR, NO or S;

W2 is N or NO and

wherein all unspecified positions can be substituted or unsubstituted.

152 - 157 . (canceled)

160 . The method of claim 151 , wherein G is O, T is OH, R1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q1 is NCS.

161 . The method of claim 140 , wherein said selective androgen receptor modulator (SARM) is represented by the structure of formula III:

wherein

X is a bond, O, CH 2 , NH, S, Se, PR, NO or NR;

G is O or S;

T is OH, OR, —NHCOCH 3 , or NHCOR

Z is NO 2 , CN, COOH, COR, NHCOR or CONHR,

Y is CF 3 , F, I, Br, Cl, CN, CR 3 or SnR 3 ;

Q is NHCOCH 3 , SCN, NCS, OCN, or NCO;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, halogen, alkenyl or OH; and

R 1 is CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 .

162 - 169 . (canceled)

170 . The method of claim 161 , wherein G is O, T is OH, R 1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q is NCS.

171 - 176 . (canceled)

177 . A method of treating, preventing, suppressing, inhibiting, reducing the incidence of, or reducing relapse of prostate cancer in a male subject, said method comprising the step of administering to said subject a selective androgen receptor modulator (SARM) and a gonadotropin releasing hormone (GnRH) agonist or antagonist.

178 . The method of claim 177 , wherein said selective androgen receptor modulator (SARM) is represented by the structure of formula I:

wherein:

X is a bond, O, CH 2 , NH, S, Se, PR, NO or NR;

G is O or S;

T is OH, OR, —NHCOCH 3 , or NHCOR;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, halogen, alkenyl or OH;

R 1 is CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 ;

R 2 is F, Cl, Br, I, CH 3 , CF 3 , OH, CN, NO 2 , NHCOCH 3 , NHCOCF 3 , NHCOR, alkyl, arylalkyl, OR, NH 2 , NHR, NR 2 , SR;

R 3 is F, Cl, Br, I, CN, NO 2 , COR, COOH, CONHR, CF 3 , SnR 3 , or R 3 together with the benzene ring to which it is attached forms a fused ring system represented by the structure:

Z is NO 2 , CN, COR, COOH, or CONHR;

Y is CF 3 , F, Br, Cl, I, CN, or SnR 3 ;

Q is SCN, NCS, OCN, or NCO;

n is an integer of 1-4;

m is an integer of 1-3; and

wherein all unspecified positions can be substituted or unsubstituted.

179 - 186 . (canceled)

187 . The method of claim 178 , wherein G is O, T is OH, R1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q is NCS.

188 . The method of claim 177 , wherein said selective androgen receptor modulator (SARM) is represented by the structure of formula II:

Wherein:

X is a bond, O, CH 2 , NH, S, Se, PR, NO or NR;

G is O or S;

R1 is CH3, CH2F, CHF2, CF3, CH2CH3, or CF2CF3;

T is OH, OR, —NHCOCH3, or NHCOR;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;

A is a ring selected from:

B is a ring selected from:

wherein A and B cannot simultaneously be a benzene ring;

Z is NO2, CN, COOH, COR, NHCOR or CONHR;

Y is CF3, F, I, Br, Cl, CN CR3 or SnR3,

Q1 is NCS, SCN, NCO or OCN;

Q2 is a hydrogen, alkyl, halogen, CF3, CN CR3, SnR3, NR2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R, SR,

Q3 and Q4 are independently of each other a hydrogen, alkyl, halogen, CF3, CN CR3, SnR3, NR2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R or SR;

W1 is O, NH, NR, NO or S;

W2 is N or NO and

wherein all unspecified positions can be substituted or unsubstituted .

189 - 196 . (canceled)

197 . The method of claim 188 , wherein G is O, T is OH, R1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q1 is NCS.

198 . The method of claim 177 , wherein said selective androgen receptor modulator (SARM) is represented by the structure of formula III:

wherein

X is a bond, O, CH 2 , NH, S, Se, PR, NO or NR;

G is O or S;

T is OH, OR, —NHCOCH 3 , or NHCOR

Z is NO 2 , CN, COOH, COR, NHCOR or CONHR;

Y is CF 3 , F, I, Br, Cl, CN, CR 3 or SnR 3 ;

Q is NHCOCH 3 , SCN, NCS, OCN, or NCO;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, halogen, alkenyl or OH; and

R 1 is CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 .

199 .- 206 . (canceled)

207 . The method of claim 198 , wherein G is O, T is OH, R 1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q is NCS.

208 - 213 . (canceled)

214 . A method of treating, preventing, suppressing, inhibiting or reducing the incidence of precancerous precursors of prostate cancer in a male subject, said method comprising the step of adrninistering to said subject a selective androgen receptor modulator (SARM) and a gonadotropin releasing hormone (GnRH) agonist or antagonist.

215 . The method of claim 214 , wherein said selective androgen receptor modulator (SARM) is represented by the structure of formula I:

wherein:

X is a bond, O, CH 2 , NH, S, Se, PR, NO or NR;

G is O or S;

T is OH, OR, —NHCOCH 3 , or NHCOR;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, halogen, aLkenyl or OH;

R 1 is CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 ;

R 2 is F, Cl, Br, I, CH 3 , CF 3 , OH, CN, NO 2 , NHCOCH 3 , NHCOCF 3 , NHCOR, alkyl, arylalkyl, OR, NH 2 , NHR, NR 2 , SR;

R 3 is F, Cl, Br, I, CN, NO 2 , COR, COOH, CONHR, CF 3 , SnR 3 , or R 3 together with the benzene ring to which it is attached forms a fused ring system represented by the structure:

Z is NO 2 , CN, COR, COOH, or CONHR;

Y is CF 3 , F, Br, Cl, I, CN, or SnR 3 ;

Q is SCN, NCS, OCN, or NCO;

n is an integer of 1-4;

m is an integer of 1-3; and

wherein all unspecified positions can be substituted or unsubstituted.

216 - 223 . (canceled)

224 . The method of claim 215 , wherein G is O, T is OH, R1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q is NCS.

225 . The method of claim 214 wherein said selective androgen receptor modulator (SARM) is represented by the structure of formula II:

Wherein:

X is a bond, O, CH2, NH, S, Se, PR, NO or NR;

G is O or S;

R1 is CH3, CH2F, CHF2, CF3, CH2CH3, or CF2CF3;

T is OH, OR, —NHCOCH3, or NHCOR;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;

A is a ring selected from:

B is a ring selected from:

wherein A and B cannot simultaneously be a benzene ring;

Z is NO2, CN, COOH, COR, NHCOR or CONHR;

Y is CF3, F, I, Br, Cl, CN CR3 or SnR3;

Q1 is NCS, SCN, NCO or OCN;

Q2 is a hydrogen, alkyl, halogen, CF3, CN CR3, SnR3, NR2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R, SR,

Q3 and Q4 are independently of each other a hydrogen, alkyl, halogen, CF3, CN CR3, SnR3, NR2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R or SR;

W1 is O, NH, NR, NO or S;

W2 is N or NO and

wherein all unspecified positions can be substituted or unsubstituted.

226 - 234 . (canceled)

235 . The method of claim 225 , wherein G is O, T is OH, R1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q1 is NCS.

236 . The method of claim 214 , wherein said selective androgen receptor modulator (SARM) is represented by the structure of formula III:

wherein

X is a bond, O, CH 2 , NH, S, Se, PR, NO or NR;

G is O or S;

T is OH, OR, —NHCOCH 3 , or NHCOR

Z is NO 2 , CN, COOH, COR, NHCOR or CONHR;

Y is CF 3 , F, I, Br, Cl, CN, CR 3 or SnR 3 ;

Q is NHCOCH 3 , SCN, NCS, OCN, or NCO;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, halogen, alkenyl or OH; and

R 1 is CH 3 , CH 2 F, CBF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 .

237 - 243 . (canceled)

244 . The method of claim 235 , wherein G is O, T is OH, R 1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q is NCS.

245 - 250 . (canceled)

251 . A method of treating, preventing, suppressing, inhibiting or reducing the incidence of a hormone-associated disorder in a female subject, wherein said condition is sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, menstrual disorders, infertility, endometriosis, polycystic ovarian syndome, hirsutism, acne, dyslipidemia, hypertension, obesity, muscle wasting, breast cancer, uterine cancer or ovarian cancer said method comprising the step of administering to said subject a selective androgen receptor modulator (SARM) and a gonadotropin releasing hormone (GnRH) agonist or antagonist.

252 . The method of claim 251 , wherein said selective androgen receptor modulator (SARM) is represented by the structure of formula I:

wherein:

X is a bond, O, CH 2 , NH, S, Se, PR, NO or NR;

G is O or S;

T is OH, OR, —NHCOCH 3 , or NHCOR;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, halogen, alkenyl or OH;

R 1 is CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 ;

R 2 is F, Cl, Br, I, CH 3 , CF 3 , OH, CN, NO 2 , NHCOCH 3 , NHCOCF 3 , NHCOR, alkyl, arylalkyl, OR, NH 2 , NHR, NR 2 , SR;

R 3 is F, Cl, Br, I, CN, NO 2 , COR, COOH, CONHR, CF 3 , SnR 3 , or R 3 together with the benzene ring to which it is attached forms a fuised ring system represented by the structure:

Z is NO 2 , CN, COR, COOH, or CONHR;

Y is CF 3 , F, Br, Cl, I, CN, or SnR 3 ;

Q is SCN, NCS, OCN, or NCO;

n is an integer of 1-4;

m is an integer of 1-3; and

wherein all unspecified positions can be substituted or unsubstituted.

253 - 260 . (canceled)

261 . The method of claim 252 , wherein G is O, T is OH, R1 is CH 3 , X is O, Z isNO 2 , Y is CF 3 , and Q is NCS.

262 . The method of claim 251 , wherein said selective androgen receptor modulator (SARM) is represented by the structure of formula II:

Wherein:

X is a bond, O, CH2, NH, S, Se, PR, NO or NR;

G is O or S;

R1 is CH3, CH2F, CHF2, CF3, CH2CH3, or CF2CF3;

T is OH, OR, —NHCOCH3, or NHCOR;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;

A is a ring selected from:

B is a ring selected from:

wherein A and B cannot simultaneously be a benzene ring;

Z is NO2, CN, COOH, COR, NHCOR or CONHR;

Y is CF3, F, I, Br, Cl, CN CR3 or SnR3;

Q1 is NCS, SCN, NCO or OCN;

Q2 is a hydrogen, alkyl, halogen, CF3, CN CR3, SnR3, NR2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R, SR,

Q3 and Q4 are independently of each other a hydrogen, alkyl, halogen, CF3, CN CR3, SnR3, NR2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R or SR;

W1 is O, NH, NR, NO or S;

W2 is N or NO and

wherein all unspecified positions can be substituted or unsubstituted.

263 - 270 . (canceled)

271 . The method of claim 262 , wherein G is O, T is OH, R1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q1 is NCS.

272 . The method of claim 251 , wherein said selective androgen receptor modulator (SARM) is represented by the structure of formula III:

wherein

X is a bond, O, CH 2 , NH, S, Se, PR, NO or NR;

G is O or S;

T is OH, OR, —NHCOCH 3 , or NHCOR

Z is NO 2 , CN, COOH, COR, NHCOR or CONHR;

Y is CF 3 , F, I, Br, Cl, CN, CR 3 or SnR 3 ;

Q is NHCOCH 3 , SCN, NCS, OCN, or NCO;

R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, halogen, alkenyl or OH; and

R 1 is CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 .

273 .- 280 . (canceled)

281 . The method of claim 272 , wherein G is O, T is OH, R 1 is CH 3 , X is O, Z is NO 2 , Y is CF 3 , and Q is NCS.

282 - 286 . (canceled)