Biodegradable drug delivery vascular stent
A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.
1. A stent comprising:
a biodegradable material in the form of a generally tubular main body for insertion into a body lumen of a living being, wherein the body lumen has a lumen wall, the tubular main body has an outer surface, and the biodegradable material comprises:
a substantially biodegradable matrix comprising collagen IV, laminin, and at least one drug; and
a biodegradable strengthening material in contact with the matrix to strengthen the matrix,
wherein said stent is a biodegradable stent.
2. The stent of claim 1 , wherein the biodegradable strengthening material comprises polylactic acid.
3. The stent of claim 1 , wherein the drug is a microencapsulated drug.
4. The stent of claim 1 , wherein the biodegradable material is biocompatible.
5. The stent of claim 1 , wherein the biodegradable matrix further comprises a glycosaminoglucuronan.
6. The stent of claim 5 , wherein the glycosaminoglucuronan comprises heparin.
7. The stent of claim 1 , wherein the tubular main body is a coiled strip.
8. The stent of claim 1 , wherein the matrix is saturated with the at least one drug.
9. The stent of claim 1 , wherein the drug is an antithrombogenic drug, an antiproliferative, a genetic material, a protein, a growth factor, or a combination thereof.
10. The stent of claim 1 , wherein the matrix comprises voids therein.
11. The stent of claim 10 , wherein the at least one drug is included in the voids in the matrix.
12. The stent of claim 10 , wherein the at least one drug comprises a plurality of microcapsules included in the voids.
13. The stent of claim 1 , wherein said biodegradable strengthening material is interspersed as particles within the matrix.
14. The stent of claim 13 , wherein said biodegradable strengthening material comprises polylactic acid.
15. The stent of claim 1 , wherein said biodegradable strengthening material is positioned on the outer surface of said matrix in the form of a layer.
16. The stent of claim 15 , wherein said biodegradable strengthening material comprises polylactic acid.
17. A stent comprising:
a biodegradable material in the form of a generally tubular main body for insertion into a body lumen of a living being, wherein the body lumen has a lumen wall, the tubular main body has an outer surface, the generally tubular main body is in the form of a coiled strip for insertion into the body lumen, and the biodegradable material comprises:
a substantially biodegradable matrix; and
a biodegradable strengthening material in contact with the matrix to strengthen the matrix, wherein the biodegradable strengthening material includes a plurality of microcapsules containing a material capable of inducing crosslinking of the biodegradable strengthening material, in vivo
wherein said stent is a biodegradable stent.
18. The stent of claim 17 , wherein the biodegradable matrix comprises collagen IV and laminin.
19. The stent of claim 17 , wherein the tubular main body comprises at least one drug.
20. The stent of claim 19 , wherein the tubular main body is saturated with the one or more drugs.
21. The stent of claim 19 , wherein the drug is an antithrombogenic drug, an antiproliferative, a genetic material, a protein, a growth factor, or a combination thereof.
22. The stent of claim 17 , wherein the matrix comprises voids therein.
23. The stent of claim 22 , further comprising at least one drug included in the voids.
24. The stent of claim 17 , wherein the matrix comprises collagen IV, laminin, and at least one drug.
25. A stent comprising:
(a) a deformable biodegradable material in the form of a tubular main body for insertion into a lumen of a vessel of a living being and having an outer surface and an inner surface;
(b) a plurality of fibers disposed around the tubular main body in contact with the outer surface of the tubular main body;
(c) a film that is combined with the plurality of fibers and which defines and covers the outer surface of the tubular main body; and
(d) a plurality of apertures extending through the stent;
wherein the biodegradable material comprises:
(i) a biodegradable matrix comprising collagen IV, laminin and at least one drug; and
(ii) a biodegradable strengthening material in contact with the matrix to strengthen the matrix and comprising polylactic acid having crystalline regions; and
wherein said stent is a biodegradable stent.