2-Oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.
1 to 4 . (canceled)
5 . 2-[4-(2,2-difluorovinyl)-2-oxo-1-pyrrolidinyl]butanamide or a pharmaceutically acceptable salt thereof.
6 . A pharmaceutical composition comprising an effective amount of a compound according to claim 5 in combination with a pharmaceutically acceptable diluent or carrier.
7 . A method for treating epilepsy, epileptogenesis, seizure disorders, convulsions, bipolar disorders, mania, depression, anxiety, migraine, neuralgia, chronic pain, neuropathic pain, cerebral ischemia, essential tremor, neonatal cerebral hemorrhage, amyotrophic lateral sclerosis, spasticity, or Parkinson's disease, in a mammal in need of such treatment, comprising administering a therapeutic dose of at least one compound according to claim 5 .
8 . The method according to claim 6 , wherein the condition to be treated is epilepsy, neuropathic pain, bipolar disorder or migraine.