Growth factor-binding compounds and methods of use
View Patent ↗Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods of administering and using the growth factor binding compounds or the growth factor binding compositions are also taught. These novel growth factor binding compounds are useful for treating angiogenesis, excessive cellular proliferation, tumor growth, and a combination thereof as well as inhibiting growth factor binding to cells and phosphorylation.
1. A growth factor binding compound according to structure (I):
wherein each R1 is independently selected from the group consisting of:
wherein each R2 is independently selected from the group consisting of:
2. The growth factor binding compound according to claim 1 , wherein the compound is selected from the group consisting of compounds according to structure (I), wherein:
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3. The growth factor binding compounds according to claim 1 , wherein the compound is capable of binding to platelet derived growth factors, vascular endothelial growth factor, or a mixture of any of the foregoing.
4. A pharmaceutical composition comprising one or more growth factor binding compounds of claim 1 or a pharmaceutically acceptable salt of any of the growth factor binding compounds, and a pharmaceutically acceptable carrier.
5. The pharmaceutical composition according to claim 4 , wherein each of the growth factor binding compounds are selected from the group consisting of compounds according to structure (I), wherein:
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6. The pharmaceutical composition according to claim 4 , wherein each of the growth factor binding compounds are capable of binding to platelet derived growth factors, vascular endothelial growth factor, or a mixture of any of the foregoing.
7. The growth factor compound of claim 1 , wherein each R1 is:
and each R2 is:
8. The pharmaceutical composition according to claim 4 , wherein each R1 is:
and each R2 is: