Enhanced anti-carious dentifrices, rinses, lozenges, candies and chewing gums and methods of using same
Mouth rinses, dentifrices, lozenges, confections, chewing gums, and similar delivery vehicles containing non-toxic soluble calcium are used prior to administration of a fluoride-containing composition to increase the effectiveness of the fluoride therapy. An effective amount of calcium is released into the oral cavity and allowed to penetrate into the oral tissue. Calcium-bound fluoride deposits form in the oral tissue upon subsequent administration of the fluoride-containing composition to provide increased salivary, plaque and oral tissue fluoride concentrations.
1. A method of enhancing the cariostatic effect of fluoride on oral tissue, teeth and dental plaque in an oral cavity comprising the steps of:
delivering, in a first delivery vehicle, an amount of a soluble calcium compound into the oral cavity, wherein the first delivery vehicle has a soluble calcium concentration of at least about 30 mMol/L;
allowing calcium ions released from the soluble calcium compound to migrate to and penetrate into the oral tissue, teeth and dental plaque within the oral cavity for a sufficient delay period for solubilized calcium to be cleared from the oral cavity by swallowing or expectoration; and
following the delay period, delivering, in a second delivery vehicle, a soluble fluoride-containing compound into the oral cavity whereby said calcium ions react with soluble fluoride ions released from the fluoride-containing compound in the oral cavity to form calcium-bound fluoride deposits on teeth, and in the oral tissue and dental plaque.
2. The method of claim 1 , wherein the soluble calcium concentration of the first delivery vehicle is at least about 40 mMol per liter.
3. The method of claim 1 , wherein the delay period between delivering the first and second delivery vehicles is about one minute or more.
4. The method of claim 1 , wherein the delay period between delivering the first and second delivery vehicles is about two minutes or more.
5. The method of claim 1 , wherein the first and second delivery vehicles are in a form selected from the group consisting of a dentifrice, rinse, lozenge confectionary and chewing gum separately or in combination in a manner to deliver the calcium containing compound sequentially before the fluoride containing compound.
6. A method of enhancing the cariostatic effect of fluoride on oral tissue, teeth and dental plaque in an oral cavity comprising:
delivering a pre-rinse that provides a soluble calcium compound into said oral cavity wherein the pre-rinse has a soluble calcium concentration of about 30 to 400 mMol/L;
allowing an amount of calcium ions released from the soluble calcium to migrate and penetrate into the oral tissue, teeth and dental plaque;
following a delay of sufficient time for solubilized calcium to be cleared from the oral cavity by swallowing or expectoration, delivering a fluoride rinse that provides fluoride ions to the oral cavity, whereby said calcium ions released from said soluble calcium compound react with the fluoride ions in the oral tissue, on teeth and in dental plaque to form calcium-bound fluoride deposits in the dental plaque, on teeth and in the oral tissue.
7. The method of claim 1 , wherein the second delivery vehicle has a total phosphate content of less than about 40 parts per million (ppm).
8. The method of claim 6 , wherein the fluoride rinse has a total phosphate content of less than about 40 parts per million (ppm).