IP Library › Granted Patent US 7,625,559
Granted Patent B2
US 7,625,559 · App. 11/051,453 · Granted Dec 1, 2009

Antibodies against

Assignees: University of Massachusetts; Medarex, Inc.
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Quick Facts
Patent No.
US 7,625,559
App. No.
11/051,453
Granted
Dec 1, 2009
Kind
B2
Abstract

Antibodies that specifically bind to toxins of C. difficile , antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.

Claims (6)

1. A composition comprising a first monoclonal antibody, or an antigen binding portion thereof, and a second monoclonal antibody, or an antigen binding portion thereof, wherein,

(a) the first antibody, or antigen binding portion thereof, comprises a heavy and light chain variable region having the amino acid sequences set forth in SEQ ID NOs:1 and 4, respectively, and

(b) the second antibody, or antigen binding portion thereof, comprises a heavy and light chain variable region having the amino acid sequences set forth in SEQ ID NOs:54 and 58, respectively.

2. The composition of claim 1 , wherein the first or second antibody is a human antibody, a humanized antibody or a chimeric antibody.

3. The composition of claim 1 , wherein the antigen binding portion of the first or second antibody is a Fab, Fab′2, ScFv, Fd, Fv or dAb.

4. The composition of claim 1 , wherein the K D of the first or second antibody, or antigen binding portion thereof, is less than 20×10 −6 M.

Assignments (6)
MERGER Recorded Jun 3, 2015
From: MEDAREX, L.L.C.
To: E. R. SQUIBB & SONS, L.L.C.
Reel/Frame 035776/0116 →
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY DATA ON THE PATENT ASSIGNMENT COVER SHEET PREVIOUSLY RECORDED ON REEL 031582 FRAME 0141. ASSIGNOR(S) HEREBY CONFIRMS THE CONVEYING PARTY IS MEDAREX, INC. AND RECEIVING PARTY IS MEDAREX, L.L.C.. Recorded Nov 13, 2013
From: MEDAREX, INC.
To: MEDAREX, L.L.C.
Reel/Frame 031628/0318 →
MERGER Recorded Nov 12, 2013
From: MEDAREX, INC.
To: PAUL D. GOLIAN / MEDAREX, L.L.C.
Reel/Frame 031582/0141 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 6, 2005
From: AMBROSINO, DONNA; BABCOCK, GREGORY J.; BROERING, TERESA; GRAZIANO, ROBERT; HERNANDEZ, HECTOR JAVIER; LOWY, ISRAEL; MANDELL, ROBERT; MOLRINE, DEBORAH; THOMAS, WILLIAM D., JR.; ZHANG, HUI-FEN
To: MASSACHUSETTS, UNIVERSITY OF; MEDAREX, INC.
Reel/Frame 016481/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 6, 2005
From: AMBROSINO, DONNA; BABCOCK, GREGORY J.; BROERING, TERESA; GRAZIANO, ROBERT; HERNANDEZ, HECTOR JAVIER; LOWY, ISRAEL; MANDELL, ROBERT; MOLRINE, DEBORAH; THOMAS, WILLIAM D., JR.; ZHANG, HUI-FEN,
To: UNIVERSITY OF MASSACHUSETTS; MEDAREX, INC.
Reel/Frame 016481/0076 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 6, 2005
From: AMBROSINO, DONNA; BABCOCK, GREGORY J.; BROERING, TERESA; GRAZIANO, ROBERT; HERNANDEZ, HECTOR JAVIER; LOWY, ISRAEL; MANDELL, ROBERT; MOLRINE, DEBORAH; THOMAS, WILLIAM D. JR.; ZHANG, HUI-FEN
To: UNIVERSITY OF MASSACHUSETTS; MEDAREX, INC.
Reel/Frame 016487/0306 →
Continuity (3)
Provisional Application 6054235700 · Feb 6, 2004
Provisional Application 6061385400 · Sep 28, 2004
Related Publication 20050287150A1 · Dec 29, 2005