Nematode GS-like sequences
Disclosed is a nucleic acid molecule from nematodes encoding for glutamine synthetase (GS) polypeptides. The GS-like polypeptide sequence is also provided, as are vectors, host cells, and recombinant methods for production of GS-like nucleotides and polypeptides. The invention further relates to screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
1 . A purified polypeptide comprising an amino acid sequence that is at least 80% identical to the amino acid sequence of SEQ ID NO: 3.
2 . The purified polypeptide of claim 1 , wherein the amino acid sequence is at least 90% identical to the amino acid sequence of SEQ ID NO: 3.
3 . The purified polypeptide of claim 2 , wherein the amino acid sequence is at least 95% identical to the amino acid sequence of SEQ ID NO: 3.
4 . The purified polypeptide of claim 3 , wherein the amino acid sequence is the amino acid sequence of SEQ ID NO: 3.
5 - 16 . (canceled)
17 . A polypeptide that binds specifically to an antibody that binds specifically to a polypeptide consisting of the amino acid sequence of SEQ ID NO:3.
18 . (canceled)
19 . The purified polypeptide of claim 1 wherein the amino acid sequence is at least 85% identical to the amino acid sequence of SEQ ID NO:3.
20 . The purified polypeptide of claim 1 wherein the amino acid sequence is at least 98% identical to the amino acid sequence of SEQ ID NO:3.
21 . The purified polypeptide of any of claims 1 - 3 , 19 and 20 wherein the polypeptide has glutamine synthetase activity.