Composition containing polyamine transport inhibitor and use thereof
Proliferative cutaneous disease states or conditions are treated by administering a polyamine transport inhibitor R-X-L-polyamine wherein R is a straight or branched C10-50 saturated or unsaturated aliphatic, carboxyalkyl, carbalkoxyalkyl, or alkoxy; a C1-8 alicyclic; a single or multiring aryl substituted or unsubstituted aliphatic; and aliphatic-substituted or unsubstituted single or multiring aromatic; a single or multiring heterocyclic; a single or multiring heterocyclic aliphatic; an aryl sulfonyl; X is —CO—, —SO 2 —, or —CH 2 —; and L is a covalent bond or a naturally occurring amino acid, lysine, ornithine, 2,4-diaminobutyric acid, or pharmaceutically acceptable salts thereof or prodrug thereof, and a polyamine biosynthesis inhibitor.
1. A method for inhibiting or reducing hair growth, which comprises administering to a patient in need thereof a polyamine transport inhibitor, wherein the polyamine transport inhibitor is selected from the compounds
or pharmaceutically acceptable salts thereof or prodrugs thereof, and a polyamine biosynthesis inhibitor.
2. The method of claim 1 wherein the polyamine biosynthesis inhibitor is an ornithine decarboxylate (ODC) inhibitor.
3. The method of claim 1 wherein the biosynthesis inhibitor is a spermidine synthase inhibitor.
4. The method of claim 1 wherein the biosynthesis inhibitor is a spermine synthase inhibitor.
5. The method of claim 1 wherein the biosynthesis inhibitor is a deoxyhypusine synthase inhibitor.
6. The method of claim 1 wherein the biosynthesis inhibitor is an inhibitor of ODC enzyme induction.
7. The method of claim 1 wherein the biosynthesis inhibitor is an antizyme inducing agent.
8. The method of claim 1 wherein the polyamine transport inhibitor and polyamine biosynthesis inhibitor are administered simultaneously.
9. The method of claim 1 wherein the polyamine transport inhibitor and polyamine biosynthesis inhibitor are administered sequentially.