Treatment and prevention of abnormal cellular proliferation
View Patent ↗This invention provides a method for inhibiting or preventing the abnormal growth of cells, including transformed cells, by administering an effective amount of O-acylated heparin derivative. Abnormal growth of cells refers to cell growth independent of normal regulatory mechanism (e.g. loss of contact inhibition). This includes the abnormal growth of: (1) tumor cells (tumors); (2) benign and malignant cells of other proliferative disease in which aberrant cellular proliferation occurs; (3) aberrant smooth muscle cell proliferation, such as might occur following treatment for coronary atherosclerosis such as angioplasty or the insertion of a stent into an occluded vessel.
1. A method of treating a malignancy or cancer of the colon comprising: providing an effective amount of an O-acylated heparin near or into a site of a tumor of the colon, to thereby decrease in size, or cease the growth of the malignancy or cancer of the colon.
2. The method of claim 1 , wherein the O-acylated heparin is an O-hexanoylated heparin derivative.
3. The method of claim 1 , wherein the O-acylated heparin is an O-butanoylated heparin derivative.
4. The method of claims 1 , 2 , or 3 , wherein the malignancy or cancer of the colon is colon cancer.