1-[2H-1-benzopyran-2-one-8-yl]-piperazine derivatives for the treatment of pain
The invention relates to a novel use of known 1-[2H-1-benzopyran-2-one-8-yl]-piperazine derivatives, broad spectrum 5-HT receptor binding compounds, having amongst other functional serotonin receptor activities, potent 5-HT 1A -agonistic as well as 5-HT 1D -antagonistic activity. The compounds of the invention are useful for the preparation of medicaments for treating pain. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description
1 . Use of a compound having 5-HT 1D receptor antagonistic activity for the preparation of a pharmaceutical composition for the treatment of pain.
2 . Use of a compound having 5-HT 1A receptor agonistic activity and 5-HT 1D receptor antagonistic activity for the preparation of a pharmaceutical composition for the treatment of pain.
3 . Use as claimed in any of the claims 1 or 2 , characterized in that said compound has the general formula (1):
wherein:
R 1 is alkyl(1-4C), alkoxy(1-4C), hydroxyl, alkoxy(1-4C)alkyl(1-4C), pyrrolidinyl, piperidinyl, morpholinyl, halogen, cyano, trifluoromethyl, amino, or mono- or disubstituted amino wherein the substituents are alkyl(1-4C), or alkyl(1-4C) carbonyl,
m has the value 0, 1 or 2,
R 2 is alkyl(1-4C), alkoxy(1-4C), halogen or trifluoromethyl,
n is 0 or 1, on the understanding that (m+n) is at least 1,
R 3 is hydrogen, alkyl(1-3C) or alkenyl(2-3C)
R 4 is alkyl(1-4C), and
p has the value 0, 1 or 2,
and all stereoisomers, and pharmacologically acceptable salts thereof:
4 . Use as claimed in claim 3 , characterized in that in said compound is 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one and the salts thereof, i.e. the compound of formula (1) wherein (R 1 ) m is 3-NH 2 , (R 2 ) n , R 3 and (R 4 ) p are hydrogen, thus having formula (2):
5 . Use as claimed in claim 4 , characterized in that in said compound is the mono hydrochloric acid mono hydrate of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one.
6 . Use as claimed in any of the claims 1 - 5 , characterized in that said pain is chronic pain including nociceptive, neuropathic, psychogenic pain, and mixed category pain (nociceptive and neuropathic components), including, but not limited to, diabetic neuropathy, neurogenic pain, central pain, somatic pain, visceral and cancer pain, inflammatory pain, post-operative pain, chronic low back pain, sciatica, cervical and lumbar pain, tension headaches, cluster headaches, chronic daily headaches, herpes neuralgia and post-herpetic neuralgia, facial and oral neuralgias and myofascial pain syndromes, phantom limb pain, stump pain and paraplegic pain, dental pain, opioid resistant pain, post-surgical pain including cardic surgery and mastectomy, pain of labour and delivery, post-partum pain, post-stroke pain, angina pain, genitourinary tract pain including pelvic pain and cystitis and vulvar vestibulitis and orchialgia, irritable bowel syndrome, pre-menstrual syndrome pain, pain resulting from burns or chemical injury or sunburn, and bone injury pain