Nematode GS-like sequences
Disclosed is a nucleic acid molecules from nematodes encoding for glutamine synthetase (GS) polypeptides. The GS-like polypeptide sequence is also provided, as are vectors, host cells, and recombinant methods for production of GS-like nucleotides and polypeptides. The invention further relates to screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
1 . A purified polypeptide comprising an amino acid sequence that is at least 85% identical to the amino acid sequence of SEQ ID NO: 2.
2 . The purified polypeptide of claim 1 , wherein the amino acid sequence is at least 90% identical to the amino acid sequence of SEQ ID NO: 2.
3 . The purified polypeptide of claim 2 , wherein the amino acid sequence is at least 95% identical to the amino acid sequence of SEQ ID NO: 2.
4 . A purified polypeptide comprising the amino acid sequence of SEQ ID NO: 2.
5 - 17 . (canceled)
18 . The purified polypeptide of claim 1 wherein the polypeptide has amide synthetase activity.