Nematode PPPT-like sequences
Disclosed are a nucleic acid molecule from nematodes encoding for purine/pyrimidine phosphoribosyl transferase (PPPT) polypeptides. The PPPT-like polypeptide sequence is also provided, as are vectors, host cells, and recombinant methods for production of PPPT-like nucleotides and polypeptides. The invention further relates to screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
1 - 13 . (canceled)
14 . A purified polypeptide comprising an amino acid sequence that is at least 80% identical to the amino acid sequence of SEQ ID NO: 4.
15 . The purified polypeptide of claim 14 , wherein the polypeptide comprises an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO: 4.
16 . The purified polypeptide of claim 15 , wherein the polypeptide comprises an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 4.
17 . The purified polypeptide of claim 16 , wherein the polypeptide comprises an amino acid sequence of SEQ ID NO: 4.
18 . The purified polypeptide of claim 14 , wherein the polypeptide has phosphoribosyl transferase activity.