Pharmaceutical composition for treating and/or preventing a pathology associated with an obsessional behavior or with obesity
View Patent ↗This invention relates to the use of a ligand of the 5-HT 4 receptor or of a pharmaceutically acceptable salt of this ligand and to a nucleic acid coding for a 5-HT 4 receptor or of a functionally equivalent receptor for a drug for treating and/or preventing a pathology associated with an obsessional behavior such as anorexia, bulimia and the addiction to drugs of abuse or obesity. The invention also relates to a method for identifying a compound that is biologically active in the treatment and/or the prevention of a pathology associated with an obsessional conduct or obesity including: a) placing the 5-HT 4 receptor or a functionally equivalent receptor in contact with this biologically active compound, and b) the determination of whether this biologically active compound is capable of modulating the basal activity of the 5-HT 4 receptor or of a functionally equivalent receptor.
1. A method of treating obsessional eating behavior of obesity in a mammal in need thereof comprising administering a therapeutically effective amount of a specific agonist of a 5-HT 4 receptor or of a pharmaceutically acceptable salt of the agonist to the mammal to inhibit food ingestion and treat the obsessional eating behavior of obesity in the mammal.
2. The method according to claim 1 , wherein the agonist is BIMU8 (endo-N-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2,3-dihydro-3-isopropyl-2-oxo-1H-benzimidazol-1-carboxamide hydrochloride).
3. A method of treating obsessional eating behavior of a bulimic mammal in need thereof comprising administering a therapeutically effective amount of a specific agonist of a 5-HT 4 receptor or of a pharmaceutically acceptable salt of the agonist to the mammal to inhibit food ingestion and treat the obsessional eating behavior of the bulimic mammal.
4. The method according to claim 3 , wherein the agonist is BIMU8 (endo-N-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2,3-dihydro-3-isopropyl-2-oxo-1H-benzimidazol-1-carboxamide hydrochloride).