Method of treating skin inflammation
View Patent ↗Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17 and/or IL-23.
1. A method of treating skin inflammation in a subject comprising:
a) measuring IL-17A, IL-17F, or both, in a non-lesional psoriatic skin sample from said subject using real-time PCR,
b) determining that said subject exhibits at least 5-fold higher expression of IL-17A, IL-17F, or both compared to a normal skin sample, and
c) administering an antagonist of IL-23 to effectively treat skin inflammation in said subject wherein said antagonist is an antibody or binding fragment thereof.
2. The method of claim 1 , wherein the skin inflammation is cutaneous inflammation.
3. The method of claim 2 , wherein the cutaneous inflammation is psoriasis.
4. The method of claim 1 , wherein the antibody or binding fragment thereof is a monoclonal antibody or binding fragment thereof.
5. The method of claim 1 , wherein the antibody or binding fragment thereof is a humanized antibody or binding fragment thereof.
6. The method of claim 1 , wherein the antibody or binding fragment thereof is a human antibody or binding fragment thereof.
7. The method of claim 1 wherein the treating of skin inflammation comprises prophylactic treatment.