Imidazoyl-benzamide anti-cancer agents

1. A compound of Formula V

or a pharmaceutically acceptable salt thereof, wherein

R 2 is hydrogen or lower alkyl;

R 3 is lower alkyl substituted with a hydroxyl or a phosphate ester thereof;

R 11 is hydrogen, cyano, nitro, or halo; sulfonyl

R 12 is lower alkoxy or 2,2,2-trifluoro-1-methyl-ethoxy;

R 13 is hydrogen;

R 14 is 1H-imidazol-2-yl, pyrazol-3-yl, or 1H-imidazol-4-yl, each of which is optionally substituted with one, two, or three groups chosen from lower alkyl, halo, acyl, sulfonyl, cyano, nitro, amino, heteroaryl, trifluoromethyl, trifluoroethyl, lower alkyl substituted with hydroxy or lower alkoxy, and lower alkyl substituted with an amino group wherein the amino group is further optionally substituted with a lower alkyl group and/or a group —C(O)R b wherein R b is chosen from hydrogen, lower alkoxy, amino, (lower alkyl)amino, di-(lower alkyl)amino, C 1 -C 6 alkyl, aryl, and heteroaryl; and

R 15 is chosen from hydrogen, halo, hydroxyl, and lower alkyl.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 15 is hydrogen.

3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 11 is chloro or cyano.

4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 12 is propoxy or 2,2,2-trifluoro-1-methyl-ethoxy.

5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is hydrogen.

6. A composition comprising a pharmaceutical excipient and a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 14 is chosen from 1H-imidazol-2-yl, and 1H-imidazol-4-yl, each of which is optionally substituted with one or two groups chosen from lower alkyl, lower alkyl substituted with hydroxy, and lower alkyl substituted with an amino group wherein the amino group is further substituted with a group —C(O)R b wherein R b is C 1 -C 6 alkyl.

8. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 14 is chosen from

2-(1-Acetylamino-ethyl)-1-ethyl-1H-imidazol-4-yl;

2-acetyl-1-ethyl-1H-imidazol-4-yl;

2-(1-Acetylamino-propyl)-1-ethyl-1H-imidazol-4-yl;

2-(1-Acetylamino-ethyl)-1-ethyl-1H-imidazol-4-yl;

2-[1-(Acetyl-methyl-amino)-ethyl]-1-ethyl-1H-imidazol-4-yl;

2-(1-Acetylamino-ethyl)-1-propyl-1H-imidazol-4-yl;

2-(1-Acetylamino-ethyl)-1-ethyl-1H-imidazol-4-yl;

2-[1-(3-methyl-ureido)-ethyl]-1-ethyl-1H-imidazol-4-yl;

2-(1-Acetylamino-ethyl)-1-isopropyl-1H-imidazol-4-yl

2-(1-Acetylamino-2-methyl-propyl)-1-ethyl-1H-imidazol-4-yl;

2-(1-(isopropoxycarbonylamino)-ethyl)-1-ethyl-1H-imidazol-4-yl;

2-(1-formylamino-ethyl)-1-ethyl-1H-imidazol-4-yl;

2-(1-methyl-1-hydroxy-ethyl)-1-ethyl-1H-imidazol-4-yl;

2-acetyl-1-(3-hydroxypropyl)-1H-imidazol-4-yl;

2-t-butyl-1-ethyl-1H-imidazol-4-yl;

2-t-butyl-1-methyl-1H-imidazol-4-yl;

2-acetyl-1-methyl-1H-imidazol-4-yl;

2-isobutyryl-1-methyl-1H-imidazol-4-yl;

2-acetyl-1-(2-hydroxy-ethyl)-1H-imidazol-4-yl;

2-(1-methyl-1-hydroxy-ethyl)-1-ethyl-1H-imidazol-4-yl;

2-(3-hydroxy-pent-3-yl)-1-ethyl-1H-imidazol-4-yl;

2-(1-hydroxy-1-methyl-ethyl)-1-(2,2,2-trifluoroethyl)-1H-imidazol-4-yl;

2-acetyl-1-(2-methoxyethyl)-1H-imidazol-4-yl;

2-acetyl-1-propyl-1H-imidazol-4-yl;

2-(1-hydroxy-2-methyl-propyl)-1-ethyl-1H-imidazol-4-yl;

2-(1-hydroxy-1-methyl-ethyl)-1-ethyl-1H-imidazol-4-yl;

2-propionyl-1-methyl-1H-imidazol-4-yl;

2-(1-hydroxy-1-methyl-ethyl)-1-(2,2,2-trifluoroethyl)-1H-imidazol-4-yl;

2-(1-formylamino-ethyl)-1-methyl-1H-imidazol-4-yl;

2-(1-hydroxy-1-methyl-ethyl)-1-methyl-1H-imidazol-4-yl;

2-(1-acetylamino-ethyl)-1-methyl-1H-imidazol-4-yl;

2-(1-hydroxy-1-methyl-ethyl)-1-ethyl-1H-imidazol-4-yl; and

2-(3-hydroxy-pent-3-yl)-1-ethyl-1H-imidazol-4-yl.

9. The compound of claim 8 , or a pharmaceutically acceptable salt thereof, wherein R 14 is chosen from

2-(1-Acetylamino-ethyl)-1-ethyl-1H-imidazol-4-yl;

2-(1-methyl-1-hydroxy-ethyl)-1-ethyl-1H-imidazol-4-yl; and

2-(1-hydroxy-1-methyl-ethyl)-1-methyl-1H-imidazol-4-yl.

10. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is —CH 2 CH 2 OH.