Granted Patent
B2
US 7,763,626 · App. 11/129,790 · Granted Jul 27, 2010
Compositions and method for enhancing the therapeutic activity of opiods in treatment of pain
Assignee:
Trustees of Dartmouth College
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Abstract
Compositions and methods for inhibiting opioid tolerance and opioid withdrawal-induced hyperalgesia are provided.
Claims (5)
1. A pharmaceutical composition for inhibition of opioid tolerance and opioid withdrawal-induced hyperalgesia comprising:
a) Propentofylline;
b) an opioid drug; and
c) a pharmaceutically acceptable carrier, and wherein said composition is administered intrathecally at a dose of Propentofylline of 10 micrograms.
2. The pharmaceutical composition of claim 1 wherein the opioid is morphine.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Feb 17, 2010
From: DARTMOUTH COLLEGE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 023943/0499 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 28, 2005
From: DELEO, JOYCE A.
To: TRUSTEES OF DARTMOUTH COLLEGE
Reel/Frame 016815/0821 →
Continuity (2)
Provisional Application
6058087600
· Jun 18, 2004