Therapeutic peptides for demyelinating conditions
The invention provides peptide compositions and methods of making and using therapeutic compositions comprising peptides for the treatment of a subject having a demyelinating condition.
1. A composition comprising a synthetic peptide having an amino acid sequence selected from the group consisting of:
AAEAYKAYKAAAAAA,
(SEQ ID NO: 60)
EAAAYKAYKAAAAAA,
(SEQ ID NO: 63)
AKKEYAEYKAAAAAA,
(SEQ ID NO: 67)
EAPAYKAYKAAAAPA,
(SEQ ID NO: 83)
EKPKYEAYKAAAAPA,
(SEQ ID NO: 85)
AKPEYAEYKAAAAPA,
(SEQ ID NO: 87)
EAPKFEAYKAAAAPA,
(SEQ ID NO: 98),
and
EAPKVEAYKAAAAPA
(SEQ ID NO: 99)
further comprising substitution of a tyrosine (Y) in the P1 position of the peptide by a valine (V) in those sequences having a tyrosine in the P1 position.
2. A composition comprising a synthetic peptide having an amino acid sequence selected from the group consisting of:
AAEAYKAYKAAAAAA (SEQ ID NO: 60),
EAAAYKAYKAAAAAA (SEQ ID NO: 63),
EAAKYEAYKAAAAAA (SEQ ID NO: 64),
EKAKYEAYKAAAAAA (SEQ ID NO: 65),
EAKKYEAYKAAAAAA (SEQ ID NO: 66),
AKKEYAEYKAAAAAA (SEQ ID NO: 67),
EAPAYKAYKAAAAPA (SEQ ID NO: 83),
EAPKYEAYKAAAAPA (SEQ ID NO: 84),
EKPKYEAYKAAAAPA (SEQ ID NO: 85),
EAPKYEAYKAAAAPA (SEQ ID NO: 86),
AKPEYAEYKAAAAPA (SEQ ID NO: 87),
APEKAKYEAYKAAAAAA (SEQ ID NO: 88),
APEKAKYEAYKAAAAAAPA (SEQ ID NO: 89),
EKAKYEAYKAAAAAAPA (SEQ ID NO: 90),
EKPKFEAYKAAAAPA (SEQ ID NO: 91),
EKPKVEAYKAAAAPA (SEQ ID NO: 93),
EKAKFEAFKAAAAAA (SEQ ID NO: 95),
APEKAKFEAFKAAAAPA (SEQ ID NO: 96),
APEKAKFEAYKAAAAPA (SEQ ID NO: 97),
EAPKFEAYKAAAAPA (SEQ ID NO: 98), and
EAPKVEAYKAAAAPA (SEQ ID NO: 99),
further comprising substitution of a tyrosine (Y) in the P1 position by a valine (V).
3. A kit comprising at least one container having a peptide as shown in claim 1 , in a pharmaceutically acceptable buffer, and instructions for use.
4. A kit comprising at least one container having a peptide as shown in claim 2 , in a pharmaceutically acceptable buffer, and instructions for use.