Adjuvancy and immune potentiating properties of natural products of
The present invention relates to a method for potentiating a specific immune response to an antigen in a mammal in need thereof. The method comprises administering to the mammal an effective amount of Ov-ASP, or at least one subunit of Ov-ASP, and an antigenic moiety.
1. An immunogenic composition capable of inducing an immune response in a mammal against an antigen, said composition comprising an isolated antigen unrelated to Onchocerca volvulus activation-associated secreted protein (Ov-ASP), said antigen mixed with an adjuvant comprising an effective amount of an isolated full-length Ov-ASP comprising the amino acid sequence of SEQ ID NO: 1.
2. The composition according to claim 1 , wherein the antigen is a polyamino acid.
3. The composition of claim 2 , wherein the polyamino acid is an isolated SARS-CoV polyamino acid.
4. The composition of claim 3 , wherein the SARS-CoV polyamino acid is the SARS-CoV SC-1 peptide.
5. The composition of claim 2 , wherein the polyamino acid is an isolated HIV-1-CD4 polyamino acid.
6. The composition of claim 5 , wherein the HIV-1-CD4 polyamino acid is the HIV-1-CD4-FLSC polypeptide.
7. The composition of claim 1 , wherein the composition is for administration to a mammal.
8. The composition of claim 1 , wherein the immune response induced against the antigen in said mammal is a humoral immune response.
9. The composition of claim 1 , wherein the immune response induced against the antigen in said mammal is a cell-mediated immune response.
10. The composition of claim 9 , wherein the cell-mediated immune response is a Th1 response.
11. The composition of claim 9 , wherein the cell-mediated immune response is a Th2 response.
12. The composition of claim 9 , wherein the cell-mediated immune response is a Th1 and a Th2 response.
13. The composition of claim 1 , wherein the antigen to the Ov-ASP ratio by weight is from 4:1 to 1:1.
14. The composition of claim 1 , wherein the antigen to the Ov-ASP ratio by weight is from 4:1 to 1:4.
15. The method of potentiating a specific immune response to an antigen in a mammal in need thereof, the method comprising administering to the mammal the immunogenic composition of any one of claims 1 - 14 .