Method and apparatus for delivering epinephrine
A method of administering epinephrine to a patient includes administering a first dose by automatic injection followed by administering a second dose by manual injection. The first and second injections are administered using the same syringe. In some embodiments, the first and second injections provide the same volume of medicine to the patient. In particular embodiments, the first and second injections have volumes of 0.15 or 0.3 ml.
1 . A method of treating allergic emergency in a patient, comprising automatically injecting into a patient in need thereof a first dose of epinephrine consisting essentially of about 0.3 mL of an epinephrine solution and optionally subsequently manually injecting into the patient a second dose of epinephrine consisting essentially of about 0.3 mL the epinephrine solution, wherein the epinephrine solution consists essentially of about 1 mg of epinephrine per mL of solution.
2 . The method of claim 1 , wherein the first dose is injected subcutaneously.
3 . The method of claim 2 , wherein the second dose is injected subcutaneously.
4 . The method of claim 2 , wherein the second dose is injected intramuscularly.
5 . The method of claim 1 , wherein the first dose is injected intramuscularly.
6 . The method of claim 5 , wherein the second dose is injected subcutaneously.
7 . The method of claim 5 , wherein the second dose is injected subcutaneously.
8 . The method of claim 1 , wherein the second dose is injected less than about 30 minutes after the first dose.
9 . The method of claim 1 , wherein the second dose is injected less than about 20 minutes after the first dose.
10 . The method of claim 1 , wherein the second dose is injected less than about 10 minutes after the first dose.
11 . The method of claim 1 , wherein the patient weighs at least about 30 Kg.
12 . The method of claim 1 , wherein the patient weighs at least about 15 Kg.
13 . The method of claim 1 , wherein the patient is an adult.
14 . The method of claim 1 , wherein the patient is a child of age 12 or older.
15 . The method of claim 1 , wherein the first dose is self administered by the patient.
16 . The method of claim 15 , wherein the second dose is self-administered by the patient.
17 . The method of claim 15 , wherein the second dose is administered by someone other than the patient.
18 . The method of claim 1 , wherein the first dose is administered by someone other than the patient.
19 . The method of claim 18 , wherein the second dose is self-administered.
20 . The method of claim 18 , wherein the second dose is administered by someone other than the patient.
21 . A method of treating allergic emergency in a patient, comprising automatically injecting into a patient in need thereof a first dose of epinephrine consisting essentially of about 0.15 mL of an epinephrine solution and optionally subsequently manually injecting into the patient a second dose of epinephrine consisting essentially of about 0.15 mL the epinephrine solution, wherein the epinephrine solution consists essentially of about 1 mg of epinephrine per mL of solution.
22 . The method of claim 21 , wherein the first dose is injected subcutaneously.
23 . The method of claim 22 , wherein the second dose is injected subcutaneously.
24 . The method of claim 22 , wherein the second dose is injected intramuscularly.
25 . The method of claim 21 , wherein the first dose is injected intramuscularly.
26 . The method of claim 25 , wherein the second dose is injected subcutaneously.
27 . The method of claim 25 , wherein the second dose is injected subcutaneously.
28 . The method of claim 21 , wherein the second dose is injected less than about 30 minutes after the first dose.
29 . The method of claim 21 , wherein the second dose is injected less than about 20 minutes after the first dose.
30 . The method of claim 21 , wherein the second dose is injected less than about 10 minutes after the first dose.
31 . The method of claim 21 , wherein the patient weighs at least about 30 Kg.
32 . The method of claim 21 , wherein the patient weighs at least about 15 Kg.
33 . The method of claim 21 , wherein the patient is an adult.
34 . The method of claim 21 , wherein the patient is a child of age 12 or older.
35 . The method of claim 21 , wherein the first dose is self administered by the patient.
36 . The method of claim 35 , wherein the second dose is self-administered by the patient.
37 . The method of claim 35 , wherein the second dose is administered by someone other than the patient.
38 . The method of claim 21 , wherein the first dose is administered by someone other than the patient.
39 . The method of claim 38 , wherein the second dose is self-administered.
40 . The method of claim 38 , wherein the second dose is administered by someone other than the patient.
41 . A drug delivery device containing an epinephrine solution, wherein the device comprises means for delivering the first dose of about 0.3 mL of the epinephrine solution by automatic injection and means for delivering the second dose of about 0.3 mL of the epinephrine solution by manual injection, wherein the epinephrine solution consists essentially of about 1 mg epinephrine per mL of solution.
42 . A kit for treating an allergic emergency, comprising the drug delivery device of claim 42 and instructions for administering the first dose of epinephrine solution automatically and the second dose of epinephrine solution manually.
43 . A kit according to claim 42 , further comprising a means for holding the drug delivery device and the instructions.
44 . A drug delivery device containing an epinephrine solution, wherein the device comprises means for delivering the first dose of about 0.15 mL of the epinephrine solution by automatic injection and means for delivering the second dose of about 0.15 mL of the epinephrine solution by manual injection, wherein the epinephrine solution consists essentially of about 1 mg epinephrine per mL of solution.
45 . A kit for treating an allergic emergency, comprising the drug delivery device of claim 44 and instructions for administering the first dose of epinephrine solution automatically and the second dose of epinephrine solution manually.
46 . The kit according to claim 45 , further comprising a means for holding the drug delivery device and the instructions.