Isoquinoline derivatives and methods of use thereof
The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.
1. A method for making a compound of formula 13a
the method comprising allowing a compound having the formula
to react with the compound having the formula
in the presence of triethylamine, for under conditions that are sufficient to make the compound of formula 13a.
2. A method for making a compound of the formula
the method comprising the steps of:
(i) allowing Compound 13a
to react with chlorosulfonic acid under conditions that are sufficient to make Compound 7
(ii) allowing Compound 7 to react with the compound of the formula
in the presence of triethylamine or sodium carbonate, under conditions that are sufficient to make Compound 8l.
3. A method for making a compound of the formula
comprising allowing Compound 8l
to react with methanesulfonic acid under conditions that are sufficient to make Compound 8l (mesylate salt).