Neo-tryptophan
View Patent ↗The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.
1. A method of making a neurotensin polypeptide containing neo-tryptophan, said method comprising:
a) providing a neo-tryptophan derivative, and
b) linking amino acid residues to said neo-tryptophan derivative to form said neurotensin polypeptide containing neo-tryptophan, wherein said neurotensin polypeptide comprises the sequence set forth in SEQ ID NOs:16 or 17.
2. The method of claim 1 , wherein said neurotensin polypeptide comprises the sequence set forth in SEQ ID NO:16.
3. The method of claim 1 , wherein said neurotensin polypeptide comprises the sequence set forth in SEQ ID NO:17.
4. The method of claim 1 , wherein said neo-tryptophan is L-neo-tryptophan.
5. The method of claim 1 , wherein said neo-tryptophan is D-neo-tryptophan.
6. The method of claim 1 , wherein said neo-tryptophan derivative comprises a blocking group.
7. The method of claim 6 , wherein said blocking group is Fmoc.
8. The method of claim 6 , wherein said blocking group is Boc.