Vegetation water composition for treatment of inflammatory skin conditions
Compositions obtained from vegetation water from olives and methods for treating patients suffering from an inflammatory skin disease with the compositions are described. Included are hydroxytyrosol rich compounds obtained from olive vegetation water.
1. A method for treating a person suffering from an inflammatory skin condition presenting as a discrete or generalized area of skin lesions, comprising:
identifying a person suffering from such an inflammatory skin condition that has proven refractory to treatment with immunosuppressives or glucocorticoids, and
orally administering to said person, an effective amount of a pharmaceutical composition selectively enriched for hydroxytyrosol, whereby the pharmaceutical composition is produced by (i) obtaining vegetation water from olives, (ii) adding acid to the vegetation water thereby producing acidified vegetation water, (iii) incubating the acidified vegetation water for a period until the weight ratio of hydroxytyrosol to oleuropein is between 4:1 and 200:1, thereby producing incubated acidified vegetation water, and (iv) adding 90 to 360 mg of solid olive extract to the incubated acidified vegetation water thereby producing the pharmaceutical composition, wherein the pharmaceutical composition is orally administered on a daily basis over a period of at least three months so as to reduce the area of the discrete or generalized skin lesions by at least 60%.
2. The method of claim 1 , wherein the acidified vegetation water is incubated for a period until the weight ratio of hydroxytyrosol to oleuropein in the composition is between about 5:1 to 50:1.
3. The method of claim 1 , wherein said oral administration comprises orally administering said composition in tablet, capsule, or pill form.
4. The method of claim 1 , wherein said oral administration comprises orally administering said composition in liquid form.
5. The method of claim 1 , wherein the inflammatory skin condition is refractory psoriasis.
6. The method of claim 1 , wherein the inflammatory skin condition is refractory eczema.
7. The method of claim 1 , wherein the inflammatory skin condition is refractory allergic dermatitis.
8. The method of claim 1 , wherein the inflammatory skin condition is refractory photohypersensitivity dermatosis.
9. The method of claim 1 , wherein the inflammatory skin condition is refractory lichen urticatus.
10. The method of claim 1 , wherein the composition is administered at a dosage effective to deliver between about 5.4 to 10.8 mg of total polyphenols daily.
11. The method of claim 1 , wherein the composition is administered at a dosage effective to deliver between about 2.5 to 5 mg of hydroxytyrosol daily.
12. The method of claim 1 , wherein the immunosuppressive are selected from the group consisting of tacrolimus and hydroxyurea.