IP Library › Granted Patent US 7,217,688
Granted Patent B2
US 7,217,688 · App. 11/186,629 · Granted May 15, 2007

Methods and compositions for derepression of IAP-inhibited caspase

Assignees: The Burnham Institute; Torrey Pines Institute for Molecular Studies
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Quick Facts
Patent No.
US 7,217,688
App. No.
11/186,629
Granted
May 15, 2007
Kind
B2
Abstract

The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.

Claims (93)

1. An isolated agent comprising one of the compounds identified herein as TPI 1577-1, TPI 1577-2, TPI 1577-3, TPI 1567-5, TPI 1577-6, TPI 1577-7, TPI 1577-8, TPI 1567-11, TPI 1567-12, TPI 1567-13, TPI 1567-14, TPI 1577-9, TPI 1567-23, TPI 1567-24, TPI 1567-18, TPI 1572-8, TPI 1572-15, TPI 1572-16, TPI 1572-10, TPI 1572-11, TPI 1572-14, TPI 1572-17, TPI 1572-18, TPI 1572-19, TPI 1572-20, TPI 1572-21, TPI 1572-22 or TPI 1572-23.

2. A composition comprising an isolated agent of claim 1 in admixture with a diluent.

3. A pharmaceutical composition comprising the agent of claim 1 or 2 and a pharmaceutically acceptable carrier.

4. A complex comprising an IAP bound to an agent of claim 1 .

5. The complex of claim 4 , wherein said IAP is selected from the group consisting of XIAP, c-IAP-1, c-IAP-2, NIAP, BRUCE (Appollon), ML-IAP, ILP2, DIAP-1, DIAP-2 and survivin.

6. The isolated agent of claim 1 , wherein said compound is TPI 1577-1.

7. The composition of claim 2 , wherein said compound is TPI 1577-1.

8. The pharmaceutical composition of claim 3 , wherein said compound is TPI 1577- 1.

9. The complex of claim 4 , wherein said compound is TPI 1577-1.

10. The complex of claim 5 , wherein said compound is TPI 1577-1.

11. The isolated agent of claim 1 , wherein said compound is TPI 1572-14.

12. The composition of claim 2 , wherein said compound is TPI 1572-14.

13. The pharmaceutical composition of claim 3 , wherein said compound is TPI 1572-14.

14. The complex of claim 4 , wherein said compound is TPI 1572-14.

15. The complex of claim 5 , wherein said compound is TPI 1572-14.

16. The isolated agent of claim 1 , wherein said compound is TPI 1577-2.

17. The composition of claim 2 , wherein said compound is TPI 1577-2.

18. The complex of claim 4 , wherein said compound is TPI 1577-2.

19. The isolated agent of claim 1 , wherein said compound is TPI 1577-3.

20. The composition of claim 2 , wherein said compound is TPI 1577-3.

21. The complex of claim 4 , wherein said compound is TPI 1577-3.

22. The isolated agent of claim 1 , wherein said compound is TPI 1567-5.

23. The composition of claim 2 , wherein said compound is TPI 1567-5.

24. The complex of claim 4 , wherein said compound is TPI 1567-5.

25. The isolated agent of claim 1 , wherein said compound is TPI 1577-6.

26. The composition of claim 2 , wherein said compound is TPI 1577-6.

27. The complex of claim 4 , wherein said compound is TPI 1577-6.

28. The isolated agent of claim 1 , wherein said compound is TPI 1577-7.

29. The composition of claim 2 , wherein said compound is TPI 1577-7.

30. The complex of claim 4 , wherein said compound is TPI 1577-7.

31. The isolated agent of claim 1 , wherein said compound is TPI 1577-8.

32. The composition of claim 2 , wherein said compound is TPI 1577-8.

33. The complex of claim 4 , wherein said compound is TPI 1577-8.

34. The isolated agent of claim 1 , wherein said compound is TPI 1567-11.

35. The composition of claim 2 , wherein said compound is TPI 1567-11.

36. The complex of claim 4 , wherein said compound is TPI 1567-11.

37. The isolated agent of claim 1 , wherein said compound is TPI 1567-12.

38. The composition of claim 2 , wherein said compound is TPI 1567-12.

39. The complex of claim 4 , wherein said compound is TPI 1567-12.

40. The isolated agent of claim 1 , wherein said compound is TPI 1567-13.

41. The composition of claim 2 , wherein said compound is TPI 1567-13.

42. The complex of claim 4 , wherein said compound is TPI 1567-13.

43. The isolated agent of claim 1 , wherein said compound is TPI 1567-14.

44. The composition of claim 2 , wherein said compound is TPI 1567-14.

45. The complex of claim 4 , wherein said compound is TPI 1567-14.

46. The isolated agent of claim 1 , wherein said compound is TPI 1577-9.

47. The composition of claim 2 , wherein said compound is TPI 1577-9.

48. The complex of claim 4 , wherein said compound is TPI 1577-9.

49. The isolated agent of claim 1 , wherein said compound is TPI 1567-23.

50. The composition of claim 2 , wherein said compound is TPI 1567-23.

51. The complex of claim 4 , wherein said compound is TPI 1567-23.

52. The isolated agent of claim 1 , wherein said compound is TPI 1567-24.

53. The composition of claim 2 , wherein said compound is TPI 1567-24.

54. The complex of claim 4 , wherein said compound is TPI 1567-24.

55. The isolated agent of claim 1 , wherein said compound is TPI 1567-18.

56. The composition of claim 2 , wherein said compound is TPI 1567-18.

57. The complex of claim 4 , wherein said compound is TPI 1567-18.

58. The isolated agent of claim 1 , wherein said compound is TPI 1572-8.

59. The composition of claim 2 , wherein said compound is TPI 1572-8.

60. The complex of claim 4 , wherein said compound is TPI 1572-8.

61. The isolated agent of claim 1 , wherein said compound is TPI 1572-15.

62. The composition of claim 2 , wherein said compound is TPI 1572-15.

63. The complex of claim 4 , wherein said compound is TPI 1572-15.

64. The isolated agent of claim 1 , wherein said compound is TPI 1572-16.

65. The composition of claim 2 , wherein said compound is TPI 1572-16.

66. The complex of claim 4 , wherein said compound is TPI 1572-16.

67. The isolated agent of claim 1 , wherein said compound is TPI 1572-10.

68. The composition of claim 2 , wherein said compound is TPI 1572-10.

69. The complex of claim 4 , wherein said compound is TPI 1572-10.

70. The isolated agent of claim 1 , wherein said compound is TPI 1572-11.

71. The composition of claim 2 , wherein said compound is TPI 1572-11.

72. The complex of claim 4 , wherein said compound is TPI 1572-11.

73. The isolated agent of claim 1 , wherein said compound is TPI 1572-17.

74. The composition of claim 2 , wherein said compound is TPI 1572-17.

75. The complex of claim 4 , wherein said compound is TPI 1572-17.

76. The isolated agent of claim 1 , wherein said compound is TPI 1572-18.

77. The composition of claim 2 , wherein said compound is TPI 1572-18.

78. The complex of claim 4 , wherein said compound is TPI 1572-18.

79. The isolated agent of claim 1 , wherein said compound is TPI 1572-19.

80. The composition of claim 2 , wherein said compound is TPI 1572-19.

81. The complex of claim 4 , wherein said compound is TPI 1572-19.

82. The isolated agent of claim 1 , wherein said compound is TPI 1572-20.

83. The composition of claim 2 , wherein said compound is TPI 1572-20.

84. The complex of claim 4 , wherein said compound is TPI 1572-20.

85. The isolated agent of claim 1 , wherein said compound is TPI 1572-21.

86. The composition of claim 2 , wherein said compound is TPI 1572-21.

87. The complex of claim 4 , wherein said compound is TPI 1572-21.

88. The isolated agent of claim 1 , wherein said compound is TPI 1572-22.

89. The composition of claim 2 , wherein said compound is TPI 1572-22.

90. The complex of claim 4 , wherein said compound is TPI 1572-22.

91. The isolated agent of claim 1 , wherein said compound is TPI 1572-23.

92. The composition of claim 2 , wherein said compound is TPI 1572-23.

93. The complex of claim 4 , wherein said compound is TPI 1572-23.

Assignments (3)
CONFIRMATORY LICENSE Recorded Aug 28, 2019
From: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
To: NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR
Reel/Frame 050195/0774 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 3, 2006
From: HOUGHTEN, RICHARD A.; NEFZI, ADEL; OSTRESH, JOHN M.; PINILLA, CLEMENCIA
To: TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
Reel/Frame 017233/0488 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 3, 2006
From: REED, JOHN C.; WELSH, KATE
To: BURNHAM INSTITUTE, THE
Reel/Frame 017233/0500 →
Continuity (2)
Continuation In Part 1108471400 · Mar 17, 2005
Related Publication 20060211627A1 · Sep 21, 2006