Indazoles
This invention provides compounds of Formula (I) or (Ia): that are useful in the treatment or inhibition of LXR mediated diseases.
1. A compound having the Formula (I):
wherein:
R 1 is C 1-6 alkyl, CN, CO 2 R 5 , C(O)R 5 , C 2-6 alkenyl, C 3-8 cycloalkenyl, C 2-6 alkynyl,NR 5 R 6 , C(O)NR 5 R 6 , phenyl, thiophene, C 1-3 alkoxy, halogen, or S(O) k R 5 ;wherein:
said C 1-6 alkyl is optionally substituted with from 1 to 7 substituents independently
selected from the group consisting of halogen and OH;
k is 0, 1 or 2;
each R 5 and each R 6 is independently H, C 1-6 alkyl, C 3-8 cycloalkyl, S(O) 2 -alkylor arylalkyl; or
each R 5 and each R 6 , together with the nitrogen atom to which they are attached, form independently:
a) a 3 to 7 membered saturated ring that is optionally substituted with C 1-3 alkyl, CH 2 OH, or C(═O)NH 2 ; or
b) a 3 to 7 membered ring containing in its backbone one or twoAdditional heteroatoms that is optionally substituted with up to three substituents independently selected from the group consisting of ═O, C 1-3 alkyl, COC 1-6 alkyl, and CO 2 C 1-6 alkyl;
provided that when R 1 is S(O) k R 5 , then said R 5 of said S(O) k R 5 is not S(O) 2 -alkyl;
R 2 is C 3-8 alkyl, C 3-8 cycloalkyl, C 2-8 alkenyl, C 3-8 cycloalkenyl, C 2-8 alkynyl, aryl,arylalkyl, heteroaryl, or heteroarylalkyl, wherein said C 3-8 alkyl, said C 3-8 cycloalkyl and said arylalkyl are each optionally substituted with up tofour substituents independently selected from the group consisting of halogen, CN and OR 7 , and wherein said heteroaryl is optionally substituted with YD; or
R 2 is phenyl substituted with up to four substituents independently selected from the group consisting of C 1-3 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-3 alkoxy, C 3-8 cycloalkyl, halogen, OH, CH 2 OH, CN, NR 7 R 8 , N(R 7 )C(O)NR 5 R 6 , S(O) m R 7 , phenyl, NO 2 , C(O)R 7 , OC(O)R 7 , C(O)NR 7 R 8 , C(O)NR 7 D and YD, providing anyOH group present is not in the para position; wherein:
said C 1-3 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms;
m is 0 to 2; and
R 5 and R 6 are as previously defined;
each R 7 and each R 8 is independently H or C 1-3 alkyl; or
each R 7 and each R 8 , together with the N atom to which they are attached,form independently:
a) a 3 to 7 membered saturated ring which is optionally substitutedwith C 1-3 alkyl, CO 2 R 14 , CH 2 CO 2 R 14 , OCH 2 CO 2 R 14 , CH 2 OCH 2 CO 2 R 14 , C(O)NR 14 R 15 , CH 2 OH, or CH 2 CH 2 OH; or
b) a 3 to 7 membered ring containing in its backbone one or twoadditional heteroatoms that is optionally substituted withCH 2 CO 2 R 14 ; wherein R 14 and R 15 are each independently H or C 1-3 alkyl;
Y is a bond, CH 2 , CH 2 CH 2 , C 2-4 alkynylenyl, —O—, CH 2 OCH 2 , OCH 2 , CH 2 O, —N(R 7 )—, —N(COR 7 )—, S(O) j , —N(R 7 )CH 2 —, —N(R 7 )CONR 8 —, —N(COR 7 )CH 2 —, S(O) j CH 2 , —CH 2 N(R 7 )CH 2 —, —CH 2 N(COR 7 )CH 2 —, —OCH 2 O—, —OC(R 7 )(CO 2 R 8 )— or —CH 2 S(O) j CH 2 —; wherein R 7 and R 8 are aspreviously defined; and j is 0, 1 or 2;
D is tetrahydronaphthalene, tetrahydronaphthalol, tetralone, naphthalene,anthracene, benzyl or phenyl, each of which is optionally substitutedwith up to five independently selected R groups;
each R is independently selected from the group consisting ofC 1-6 alkyl, C 1-3 alkoxy, halogen, —C(═O)H, —C(O)—C 1-3 alkyl, CH 2 OH, CN, NH 2 , NO 2 , C 2-4 alkenyl, C 2-4 alkynyl,S(O) j R 9 , and WX; wherein said C 1-6 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; and j is 0, 1 or 2; or
D is a heterocycloalkyl, heterocycloalkylalkyl, heteroarylalkyl, heteroaryl or arylalkyl group, each of which is optionally substituted with up to four independently selected R a groups;
each R a is independently selected from the group consisting ofC 1-8 alkyl, phenyl, benzyl, C 3-8 cycloalkyl C 7-11 arylalkyl,C 1-3 alkoxy, halogen, —C(═O)H, —C(O)—C 1-3 alkyl, CH 2 OH,CN, NO 2 , NH 2 , OH, ═O, C 2-6 alkenyl, C 2-4 alkynyl,S(O) j R 9 and WX; wherein said C 1-8 alkyl, said C 2-6 alkenyl, said C 2-4 alkynyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms;and
j is 0, 1 or 2;
W is a bond, —CH 2 —, —CH 2 CH 2 —, —NR 7 —, -Q-N(R 7 )—, —CHR 8 —, —(CHR 8 ) 2 —, —CHR 9 —, —CR 9 R 10 —, —CO—, —O—, —OCH 2 —, —OCHR 9 —, or —OCR 9 R 10 —;wherein R 7 and R 8 are as previously defined; and Q is C 1-6 alkylenyl;
each R 9 and each R 10 is independently C 1-3 alkyl or OH; or
any R 9 and R 10 , together with the atom to which they are attached, canform a 3 to 7 membered saturated ring that optionally containsone O, N or S atom;
X is CO 2 R 11 , COR 11 , C(R 11 ) 2 OH, CO 2 R 5 , C(O)NR 5 R 6 , NR 5 R 6 , QNR 5 CO 2 R 6 , OH, CH 2 OH, CN, SO 2 NR 5 R 6 , P(O)(OR 5 )(OR 6 ), cycloalkylalkyl, aryl, arylalkyl, heterocycloalkyl or heteroaryl,wherein:
said aryl, said arylalkyl, said heterocycloalkyl and saidheteroaryl are independently each optionally substitutedwith up to three substituents selected from the groupconsisting of C 1-3 alkyl, C 1-3 alkoxy, halogen, H, OH, NO 2 and benzyl that is optionally substituted with up to five halogen atoms; wherein said C 1-3 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms;
Q is C 1-6 alkylenyl;
R 11 is H or C 1-6 alkyl; and
R 5 and R 6 are as previously defined;
R 3 is ZA; wherein:
Z is CH 2 , or CH 2 CH 2 ;
A is naphthyl, or phenyl;—wherein said phenyl is optionally substituted with up to five independently selected R 18 groups; wherein
each said R 18 is independently selected from the group consisting of C 1-6 alkyl, C 1-3 alkoxy, halogen, OH, NO 2 , CN, phenyl, pyrrol-1-yl, C(O)R 12 , CO 2 R 12 , NR 12 R 13 , C(O)NR 12 R 13 and S(O) n R 12 ; wherein said C 1-6 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; n is 0, 1 or 2; and R 12 and R 13 are each independently H or C 1-3 alkyl;
R 20 is H or C 1-3 alkyl; and
R 4 is H, halogen, methyl or methoxy.
2. A compound of claim 1 wherein R 1 is C 1-6 alkyl, CN, CO 2 R 5 , NR 5 R 6 , or halogen; wherein said C 1-6 alkyl is optionally substituted with from 1 to 7 substituents independently selected from the group consisting of halogen and OH; and R 5 and R 6 are as previously defined.
3. A compound of claim 1 wherein R 1 is CN, halogen, or C 1-6 alkyl substituted with from 1 to 7 fluorine atoms.
4. A compound of claim 1 wherein R 1 is C 1-3 perhaloalkyl.
5. A compound of claim 1 wherein R 1 is CF 3 , F or Cl.
6. A compound of claim 1 wherein R 1 is CF 3 .
7. A compound of claim 1 wherein:
R 2 is C 3-8 alkyl, C 3-8 cycloalkyl, aryl, arylalkyl, or heterocycloalkyl; wherein
said C 3-8 alkyl, said C 3-8 cycloalkyl and said arylalkyl are each optionally substituted with up to four substituents independently selected from the group consisting of halogen, CN and OR 7 ; and
said heteroaryl is optionally substituted with YD; wherein Y and D are as previously defined; or
R 2 is phenyl substituted with up to four substituents independently selected from the group consisting of C 1-3 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-3 alkoxy, C 3-8 cycloalkyl, halogen, OH, CH 2 OH, CN, NR 7 R 8 , N(R 7 )C(O)NR 5 R 6 , S(O) m R 7 , phenyl, NO 2 , C(O)R 7 , OC(O)R 7 , C(O)NR 7 R 8 , C(O)NR 7 D and YD, providing any OH group present is not in the para position; wherein said C 1-3 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms.
8. A compound of claim 1 wherein:
R 2 is arylalkyl, heteroaryl or heteroarylalkyl, wherein:
said arylalkyl is optionally substituted with up to four substituents independently selected from the group consisting of halogen, CN and OR 7 ; and
said heteroaryl is optionally substituted with YD; or
R 2 is phenyl substituted with up to four substituents independently selected from the group consisting of C 1-3 alkyl, C 1-3 alkoxy, halogen, CH 2 OH, CN, NR 7 R 8 , N(R 7 )CONR 5 R 6 , S(O) m R 7 , NO 2 , and YD; wherein said C 1-3 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; m, R 5 , R 6 , R 7 , and R 8 are as previously defined;
Y is a bond, CH 2 , CH 2 CH 2 , C 2-4 alkynylenyl, —O—, OCH 2 , CH 2 O, —N(R 7 )—, —N(R 7 )CH 2 —, —N(R 7 )CONR 8 —, —OCH 2 O— or —OC(R 7 )(CO 2 R 8 )—; wherein R 7 and R 8 are as previously defined;
D is benzyl or phenyl, each of which is optionally substituted with up to five independently selected R groups;
each R is independently selected from the group consisting of C 1-6 alkyl, C 1-3 alkoxy, halogen, —C(═O)H, —C(O)—C 1-3 alkyl, CH 2 OH, CN, NO 2 , C 2-4 alkenyl, C 2-4 alkynyl, S(O) j R 9 , and WX; wherein said C 1-6 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; and j, R 9 and WX are as previously defined; or
D is a heterocycloalkyl, heteroarylalkyl, heteroaryl, or arylalkyl group, each of which is optionally substituted with up to four independently selected R a groups;
each R a is independently selected from the group consisting of C 1-8 alkyl, phenyl, benzyl, C 7-11 arylalkyl, C 1-3 alkoxy, halogen, C(O)H, CO(CH 3 ) 2 , C(CH 3 ) 2 OH, —C(O)—C 1-3 alkyl, CH 2 OH, CN, NO 2 , NH 2 , OH, ═O, C 2-6 alkenyl, C 2-4 alkynyl, S(O) j R 9 , and WX; wherein said C 1-8 alkyl, said C 2-6 alkenyl, C 2-4 alkynyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; and j, R 9 and WX are as previously defined.
9. A compound of claim 1 wherein R 2 is phenyl substituted with an ortho or meta OH.
10. A compound of claim 1 wherein R 2 is phenyl substituted with a meta OH.
11. A compound of claim 1 wherein:
R 2 is phenyl substituted with up to four substituents independently selected from the group consisting of C 1-3 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-3 alkoxy, C 3-8 cycloalkyl, halogen, OH, CH 2 OH, CN, NR 7 R 8 —, N(R 7 )C(O)NR 5 R 6 , S(O) m R 7 , phenyl, NO 2 , C(O)R 7 , OC(O)R 7 , C(O)NR 7 R 8 , C(O)NR 7 D and YD, providing any OH group present is not in the para position; wherein said C 1-3 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; and m, R 5 , R 6 , R 7 , R 8 , Y and D are as previously defined.
12. A compound of claim 1 wherein R 2 is phenyl substituted with YD.
13. A compound of claim 12 wherein Y is a bond, CH 2 , CH 2 CH 2 , C 2-4 alkynylenyl, —O—, OCH 2 , CH 2 O, —N(R 7 )—, —N(R 7 )CH 2 —, —N(R 7 )CONR 8 —, —OCH 2 O— or —OC(R 7 )(CO 2 R 8 ).
14. A compound of claim 13 wherein D is benzyl or phenyl, each of which is optionally substituted with up to five independently selected R groups; each R is independently selected from the group consisting of C 1-6 alkyl, C 1-3 alkoxy, halogen, —C(═O)H, —C(O)—C 1-3 alkyl, C 1-6 alkyl, C 1-3 alkoxy, halogen, C(═O)H, C 1-3 acyl, CH 2 OH, CN, NO 2 , C 2-4 alkenyl, C 2-4 alkynyl, S(O) j R 9 , and WX; wherein said C 1-6 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; and j, R 9 and WX are as previously defined.
15. A compound of claim 14 wherein D is phenyl that is optionally substituted with up to four independently selected R groups; each R is independently selected from the group consisting of C 1-6 alkyl, —C(═O)H, —C(O)—C 1-3 alkyl, C 1-3 alkoxy, halogen, CH 2 OH, CN, NO 2 , C 2-4 alkenyl, C 2-4 alkynyl, and WX; wherein said C 1-6 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; and wherein WX is previously defined.
16. A compound of claim 1 wherein R 2 is phenyl substituted with C 1-3 perfluoroalkyl.
17. A compound of claim 1 wherein R or R a is C 1-3 perfluoroalkyl or C 1-3 perfluoroalkoxy.
18. A compound of claim 1 wherein R 2 is selected from the group consisting of 2,4-dimethoxyphenyl, phenyl, 4-methoxy-2-methylphenyl, 2-methoxyphenyl, 4-methoxyphenyl, 2-methylphenyl, 2,4-dimethylphenyl, 1,1′-biphenyl-4-yl, 4-methoxy-3,5-dimethylphenyl, 2-naphthyl, 2-vinylphenyl, 4-methoxy-3-methylphenyl, 3-methylphenyl, 2,3-dimethylphenyl, 3-(trifluoromethyl)phenyl, 4-fluorophenyl, 3-chlorophenyl, 3-methoxyphenyl, benzaldehyde-2-yl, 2-isopropylphenyl, 2-cyclohexylphenyl, 2-benzylphenyl, 2-(1,1,2,2-tetrafluoroethoxy)phenyl, 2-chloro-5-fluorophenyl, 9H-fluoren-2-yl, 4-benzylphenyl, benzaldehyde-3-yl, 3-hydroxyphenyl, butyl, isobutyl, pentyl, cyclopentyl, 2-hydroxyphenyl, 1,3-dioxolan-2-yl, 4′-methoxy-1,1′-biphenyl-4-yl, 1,1′-biphenyl-4-ol, cyclohexanyl, 4-methoxy-2-methylphenyl, 4-methoxy-2-methylphenyl, 4-bromophenyl, 3-bromophenyl, 3-(benzyloxy)phenyl, and 4-phenoxy-phenyl.
19. A compound of claim 1 , wherein A is phenyl that is optionally substituted with up to five independently selected R 18 groups; wherein each said R 18 is independently selected from the group consisting of C 1-6 alkyl, C 1-3 alkoxy, halogen, OH, NO 2 , CN, phenyl, pyrrol-1-yl, C(O)R 12 , CO 2 R 12 , NR 12 R 13 , C(O)NR 12 R 13 , and S(O) n R 12 ; wherein said C 1-6 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; and n, R 12 and R 13 are as previously defined.
20. A compound of claim 1 wherein
Z is CH 2 ; and
A is phenyl, wherein said phenyl is optionally substituted with up to five independently selected R 18 groups; wherein each said R 18 is independently selected from the group consisting of C 1-6 alkyl, C 1-3 alkoxy, halogen, OH, NO 2 , and CN; wherein said C 1-6 alkyl and C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms.
21. A compound of claims 20 wherein R 18 is C 1-3 perfluoroalkyl.
22. A compound of claim 1 wherein R 3 is selected from the group consisting of benzyl, 3-methoxybenzyl, 2-naphthylmethyl, 4-methylbenzyl, 2-nitrobenzyl, 2-(trifluoromethyl)benzyl, 4-bromobenzyl, 3-(difluoromethoxy)benzyl, 3-(trifluoromethoxy)benzyl, 3,5-difluorobenzyl, 3,5-dimethylbenzyl, 2-chloro-4-fluorobenzyl, 3-(1H-pyrrol-1-yl)benzyl, 2-bromobenzyl, 2-methylbenzyl, 5-fluoro-2-methylbenzyl, 6-chloro-2-fluoro-3-methylbenzyl, 1,1′-biphenyl-3-ylmethyl, 2-chlorobenzyl, 1-naphthylmethyl, 2,5-dichlorobenzyl, (difluoromethoxy)benzyl, 3-fluorobenzyl, 4-methylbenzyl, 2,4-dimethylbenzyl, mesitylmethyl, 2,4-dimethylbenzyl, 2-phenylethyl, 2-chloro-6-fluorobenzyl, 4-chloro-2-fluorobenzyl, 4-fluorobenzyl, 4-(methylsulfonyl)benzyl.
23. A compound of claim 1 wherein R 4 is H or F.
24. The compound of claim 1 wherein:
R 1 is C 1-6 alkyl, CN, CO 2 R 5 , NR 5 R 6 , halogen; wherein said C 1-6 alkyl is optionally substituted with from 1 to 7 substituents independently selected from the group consisting of halogen and OH;
R 5 and R 6 are as previously defined;
R 2 is as previously defined;
Z is CH 2 ; and
A is phenyl, wherein said phenyl is optionally substituted with up to five independently selected R 18 groups; wherein each said R 18 is independently selected from the group consisting of C 1-6 alkyl, C 1-3 alkoxy, halogen, OH, NO 2 , and CN; wherein said C 1-6 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; and
R 4 is H or halogen.
25. A compound of claim 1 wherein:
R 1 is C 1-6 alkyl, CN, or halogen; wherein said C 1-6 alkyl is optionally substituted with from 1 to 7 fluorine atoms;
R 2 is arylalkyl, heteroaryl or heteroarylalkyl, wherein:
said arylalkyl is optionally substituted with up to four substituents independently selected from the group consisting of halogen, CN and OR 7 ; and
said heteroaryl is optionally substituted with YD;
wherein R 7 , Y and D are as previously defined; or
R 2 is phenyl substituted with up to four substituents independently selected from the group consisting of C 1-3 alkyl, C 1-3 alkoxy, halogen, CH 2 OH, CN, NR 7 R 8 , N(R 7 )CONR 5 R 6 , S(O) m R 7 , NO 2 and YD; wherein said C 1-3 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; m, R 5 , R 6 , R 7 , and R 8 are as previously defined;
Y is a bond, CH 2 , CH 2 CH 2 , C 2-4 alkynenyl, —O—, OCH 2 , CH 2 O, —N(R 7 )—, —N(R 7 )CH 2 —, —N(R 7 )CONR 8 —, —OCH 2 O— or —OC(R 7 )(CO 2 R 8 )—;
D is benzyl or phenyl, each of which is optionally substituted with up to five independently selected R groups;
each R is independently selected from the group consisting of C 1-6 alkyl, C 1-3 alkoxy, halogen, C(═O)H, —C(O)—C 1-3 alkyl, CH 2 OH, CN, NO 2 , C 2-4 alkenyl, C 2-4 alkynyl, S(O) j R 9 , and WX; wherein said C 1-6 alkyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; and j, R 9 and WX are as previously defined; or
D is a heterocycloalkyl, heteroarylalkyl, heteroaryl, or arylalkyl group, each of which is optionally substituted with up to four independently selected R a groups;
each R a is independently selected from the group consisting of, C 1-8 alkyl, phenyl, benzyl, C 7-11 arylalkyl, C 1-3 alkoxy, halogen, C(O)H, —C(O)—C 1-3 alkyl, CH 2 OH, CN, NO 2 , NH 2 , OH, ═O, C 2-6 alkenyl, C 2-4 alkynyl, S(O) j R 9 , and WX; wherein said C 1-8 alkyl, said C 2-6 alkenyl, C 2-4 alkynyl and said C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms; and j, R 9 and WX are as previously defined;
Z is CH 2 ; and
A is phenyl, wherein said phenyl is optionally substituted with up to five independently selected R 18 groups; wherein each said R 18 is independently selected from the group consisting of C 1-6 alkyl, C 1-3 alkoxy, halogen, OH, NO 2 , and CN, wherein said C 1-6 alkyl and C 1-3 alkoxy are each optionally substituted with from 1 to 7 fluorine atoms;and
R 4 is H.
26. A compound of claim 25 wherein R 18 is C 1-3 perfluoroalkyl.
27. A compound of claim 26 wherein R 2 is phenyl substituted with C 1-3 perfluoroalkyl.
28. A compound of claim 27 wherein R or R a is C 1-3 perfluoroalkyl or C 1-3 perfluoroalkoxy.
29. A compound of any of claims 7 to 18 or 19 to 28 wherein R 1 is CF 3 , F or Cl.
30. A compound of claim 1 selected from the group consisting of:
ae) 3-(4-Methoxy-2-methylphenyl)-2-(4-methyl-benzyl)-7-trifluoromethyl-2H-indazole;
af) 2-(2,4-Dimethylbenzyl)-3-(4-methoxy-2-methylphenyl)-7-trifluoromethyl-2H-indazole;
ag) 3-(4-Methoxy-2-methyl-phenyl)-7-trifluoromethyl-2-(2 ,4,6-trimethyl-benzyl)-2H-indazole;
ar) 2-(2,4-Dimethyl-benzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
as) 3-Phenyl-7-trifluoromethyl-2-(2,4,6-trimethyl-benzyl)-2H-indazole;
bc) 2-(3-Methoxybenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bd) 2-(3-Fluorobenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
be) 2-(2-Nitrobenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bf) 2-(3 ,5-Difluorobenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bh) 2-(4-Methylbenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bi) 2-(2-Trifluoromethylbenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bj) 2-(4-Bromobenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bk) 2-(2-Difluoromethoxybenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bl) 2-(3-Difluoromethoxybenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bn) 2-(3-Trifluoromethoxylbenzyl)-7-trifluoromethyl-3-phenyl-2H-indazole;
bn) 2-(3 ,5-Dimethylbenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bo) 2-Naphthalen-1-ylmethyl-3-phenyl-7-trifluoromethyl-2H-indazole;
bp) 2-(2-Chloro-4-fluorobenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bq) 3-Phenyl-2-(3-pyrrol-l -yl-benzyl)-7-trifluoromethyl-2H-indazole;
br) 2-(2-Bromobenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bs) 2-(2-Methylbenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bt) 2-(2,5-Dichlorobenzyl)-7-trifluoromethyl-3-phenyl-2H-indazole;
bu) 2-(2-Methyl-5-fluorobenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bv) 2-(6-Chloro-2-fluoro-3-methylbenzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
bw) 2-Biphenyl-3-ylmethyl-3-phenyl-7-trifluoromethyl-2H-indazole;
ce) 2-(2-Chloro-benzyl)-3-phenyl-7-trifluoromethyl-2H-indazole;
cf) 2-Naphthalen-1-ylmethyl-3-phenyl-7-trifluoromethyl-2H-indazole;
dh) 3-Phenyl-2-(2-phenylethyl)-7-(trifluoromethyl)-2H-indazole;
di) 2-(4-Fluorobenzyl)-3-phenyl-7-(trifluoromethyl)-2H-indazole;
dj) 2-(2-Chloro-6-fluorobenzyl)-3-phenyl-7-(trifluoromethyl)-2H-indazole;
dk) 2-(4-Chloro-2-fluorobenzyl)-3-phenyl-7-(trifluoromethyl)-2H-indazole;
dn) 2-(2-chloro-4-fluoro-benzyl)-3-(4-fluoro-phenyl)-7-trifluoromethyl-2H-indazole;
do) 2-(2-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole;
dp) 2-(2-chlorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole;
dq) 2-(3 ,4-difluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole;
dr) 3-(4-fluorophenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ds) 2-(2,4-difluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole;
dt) 2-(4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole;
du) 2-(4-chlorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole;
ee) 2-(2,4-dimethylbenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole;
ev) ethyl 1-{4-[2-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidine-4-carboxylate;
fo) 3-(4-chlorophenyl)-2-(2,4-dirnethylbenzyl)-7-(trifluoromethyl)-2H-indazole;
fp) 2-(4-chloro-2-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole;
fq) 2-(4-chloro-2-fluorobenzyl)-3-(4-chlorophenyl)-7-(trifluoromethyl)-2H-indazole;
fx) 3-(4-chlorophenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
fy) 2-(2-chloro-4-fluorobenzyl)-3-(4-chlorophenyl)-7-.(trifluoromethyl)-2H-indazole;
fz) 2-(2-chloro-6-fluorobenzyl)-3-(4-chlorophenyl)-7-(trifluoromethyl)-2H-indazole;
ga) 2-(2-chloro-6-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole;
gg) 3-(3 ,4-difluorophenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
gh) 2-benzyl-3-(3,4-difluorophenyl)-7-(trifluoromethyl)-2H-indazole;
gi) 3-(3 ,4-difluorophenyl)-2-(2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
gj) 2-(2,4-difluorobenzyl)-3-(3 ,4-difluorophenyl)-7-(trifluoromethyl)-2H-indazole;
gk) 2-(3 ,4-dichlorobenzyl)-3-(3 ,4-difluorophenyl)-7-(trifluoromethyl)-2H-indazole;
gl) 3-(3 ,4-difluorophenyl)-2-(3-methylbenzyl)-7-(trifluoromethyl)-2H-indazole;
gn) 3-(2,4-difluorophenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
gp) 2-(2-chlorobenzyl)-3-(4-chlorophenyl)-7-(trifluoromethyl)-2H-indazole;
gq) 2-(4-chlorobenzyl)-3-(4-chlorophenyl)-7-(trifluoromethyl)-2H-indazole;
gr) 3-(4-chlorophenyl)-2-(2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
gs) 3-(4-chlorophenyl)-2-(2,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
gt) 3-(4-chlorophenyl)-.7-(trifluoromethyl)-2-[2-(trifluoromethyl)benzyl]-2H-indazole;
gu) 3-(4-chiorophenyl)-7-(trifluoromethyl)-2-[4-(trifluoromethyl)benzyl]-2H-indazole;
gv) 3-(4-chlorophenyl)-2-(3 ,4-dichlorobenzyl)-7-(trifluoromethyl)-2H-indazole;
hd) 3-(4-chlorophenyl)-2-(3-methoxybenzyl)-7-(trifluoromethyl)-2H-indazole;
he) 3-(4-chlorophenyl)-2-(3-methylbenzyl)-7-(trifluoromethyl)-2H-indazole;
hf) 3-(4-chlorophenyl)-2-(3-nitrobenzyl)-7-(trifluoromethyl)-2H-indazole;
hg) 3-(4-chlorophenyl)-2-(2-methylbenzyl)-7-(trifluoromethyl)-2H-indazole;
hh) 3-(4-chlorophenyl)-2-(2,6-dichlorobenzyl)-7-(trifluoromethyl)-2H-indazole;
hi) (1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3-yl)methanol;
hj) (1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-yl)methanol;
hk) ethyl 1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}piperidine-4-carboxylate;
hl) 3-(3-chlorophenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
hm) 2-(4-chloro-2-fluorobenzyl)-3-(3-chlorophenyl)-7-(trifluoromethyl)-2H-indazole;
hn) 2-(2-chlorobenzyl)-3-(3-chlorophenyl)-7-(trifluoromethyl)-2H-indazole;
ho) 2-(4-chlorobenzyl)-3-(3-chlorophenyl)-7-(trifluoromethyl)-2H-indazole;
hu) 1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazoi-3-yl]phenyl }pyrrolidin-3-ol;
hv) 1-benzyl-N- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
hw) 3-(3-chlorophenyl)-2-(2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
hx) 3-(3-chlorophenyl)-2-(2,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazoie;
hy) 3-(3-chlorophenyl)-2-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazole;
hz) 3-(3-chlorophenyl)-7-(trifluoromethyl)-2-[4-(trifluoromethyl)benzyl]-2H-indazole;
ia) 3-(3-chlorophenyl)-2-(3 ,4-dichlorobenzyl)-7-(trifluoromethyl)-2H-indazoie;
ib) 3-(3-chiorophenyl)-2-(3 ,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazoie;
ic) 3-(3-chiorophenyl)-2-(3-methoxybenzyl)-7-(trifluoromethyl)-2H-indazole;
id) 3-(3-chiorophenyl)-2-(3-methylbenzyl)-7-(trifluoromethyl)-2H-indazole;
ie) 3-(3-chiorophenyl)-2-(3-nitrobenzyl)-7-(trifluoromethyl)-2H-indazole;
if) 3-(3-chlorophenyl)-2-(2-methylbenzyl)-7-(trifluoromethyl)-2H-indazole;
ig) N-methyl-l- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-amine;
ih) 3-[4-(2-methylpiperidin-1-yl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ii) 3-[4-(3-methylpiperidin-1-yl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ij) 3- [4-(4-methylpiperidin-1-yl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ik) 1- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }piperidin-3-ol;
il) (1- {4- [2-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }piperidin-3-yl)methanol;
im) (1- {4-[2-(2 ,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }piperidin-4-yl)methanol;
in) 3-(4-bromophenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
io) ethyl 1- {4- [2-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidine-3-carboxylate;
ip) 2-(1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-yl) ethanol;
iq) 4-phenyl-1- {4-112-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-ol;
ir) tert-butyl [(1- {4-112-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-yl)methyl]carbamate;
is) ((3 R)-1- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3-yl)methanol;
it) ((3 S)-1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}piperidin-3-yl)methanol;
iu) {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amine;
iv) 8- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl 1-1 ,4-dioxa-8-azaspiro[4. 5]decane;
iw) (1- {3-[2-(2,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3-yl)methanol;
ix) (1- {3-2-(2,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}piperidin-4-yl)methanol;
iy) (1- {3-[2-(2,4,6-trifluorobenzyl)-.7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3-yl)methanol;
iz) (1- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-yl)methanol;
ja) (1- {3-[2-(3-methylbenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3-yl)methanol;
jb) (1- {3-172-(3-methylbenzyl)-7-(trifluoromethyl)-2H-indazol-3 yl]phenyl }piperidin-4-yl)methanol;
jc) (1- {3-[2-(3,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3-yl)methanol;
jd) (1- {3-[2-(3 ,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-yl)methanol;
je) (1- {4-[2-(2-methylbenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3-yl)methanol;
jf) (1- {4-[2-(2-methylbenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-yl)methanol;
jg) (1- {4-[2-(2,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3-yl)methanol;
jh) N-(pyridin-4-ylmethyl)-N′- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}urea;
ji) N-(piperidin-4-ylmethyl)-N′- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }urea;
jj) N-(2-methoxybenzyl)-N′- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }urea;
jk) N-(4-bromophenyl)-N′- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }urea;
jl) N-(tetrahydrofuran-2-ylmethyl)-N′- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }urea;
jm) N-isobutyl-N′- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol...3-yl]phenyl }urea;
jn) N,N-dipropyl-N′- {4- [2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}urea;
jo) {3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amine;
jp) 2-(2-fluorobenzyl)-3-[3-(4-methylpiperidin-1-yl)phenyl]-7-(trifluoromethyl)-2H-indazole;
jq) (3 S)-1-benzyl-N- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
jr) (3 R)-1-benzyl-N- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H..indazoh3-yl]phenyl }pyrrolidin-3-amine;
js) 1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol3-yl]phenyl }piperidin-4-one;
jt) methyl ((3R)-1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }piperidin-3-yl)acetate;
jy) ((3R)-1- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3-yl)acetic acid;
jz) 1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }-N-[4-(trifluoromethyl)benzyl]piperidin-4-amine;
ka) N-(2-fluorophenyl)-N′- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }urea;
kb) ethyl 1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidine-2-carboxylate;
kc) N-phenyl-N′- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}urea;
kd) N-(2-fluorophenyl)-Nt- {4-112-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }urea;
ke) N-(2-chlorophenyl)-N′- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yllphenyl}urea;
kf) ethyl 1- {4-112-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidine-3-carboxylate;
kg) N-(2-chlorophenyl)-N′- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }urea;
kh) N-phenyl-N′- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }urea;
ki) tert-butyl ((3 S)-1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3.-yl)carbamate;
kj) tert-butyl ((3 R)-1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-yl)carbamate;
kk) N-(2-phenylethyl)-1- {4-[2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-amine;
kl) (3 S)-1-cyclohexyl-N- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-ylphenyl }pyrrolidin-3-amine;
kin) (3 S)-1- {4-112-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
kn) (3 R)-1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
ko) N-butyl-1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-amine;
kp) 3-(4-piperazin-1-ylphenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
kq) (3R)-1-(3-methylbut-2-enyl)-N- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
kr) (3 S)-1-(3-methylbut-2-enyl)-N- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
kt) (3R)-N- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }-1-(3,3,3-trifluoropropyl)pyrrolidin-3-amine;
ku) (3R)-1-(2-methylprop-2-enyl)-N- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
kv) (3R)-1-[(2E)-pent-2-enyl]-N- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
kw) (3R)-1-cyclopentyl-N- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
kx) 3- [4-(4-morpholin-4-ylpiperidin-1-yl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ky) (3R)-1-hexyl-N- {4- [2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
kz) (3 R)-1-isopropyl-N- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
la) (3 S)-1-cyclopentyl-N- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl jphenyl }pyrrolidin-3-amine;
lb) (3 S)-1-[(2E)-pent-2-enyl]-N- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
lc) (3 S)-1-(2-methylprop-2-enyl)-N- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
ld) (3 S)-N- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }-1-(3,3,3-trifluoropropyl)pyrrolidin-3-amine;
le) (3 S)-1-hexyl-N- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
lf) (3 S)-1-isobutyl-N- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
lg) 8- {3-[2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }-1 ,4-dioxa-8-azaspiro[4. 5ljdecane;
lh) 7- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }-1 ,4-dioxa-7-azaspiro [4. 5]decane;
li) 7- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl 1-1 ,4-dioxa-7-azaspiro[4. 5]decane;
lj) methyl ((3 S)-1- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }piperidin-3-yl)acetate;
lk) ((3 S)-1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}piperidin-3-yl)acetic acid;
ll) 1- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-one;
lm) 3-(4-bromophenyl)-2-(2-chloro-4-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ln) 3-[4-(4-benzoylpiperazin-1-yl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
lo) 3- {4-[4-(2-chlorobenzoyl)piperazin-1-yl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
lp) 3- {4-[4-(2-methoxybenzoyl)piperazin-1-yl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
lq) 3- {4-[4-(3-methoxybenzoyl)piperazin-1-yllphenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
lr) 3- {4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ls) methyl ((3 R)-1- {4-[2-(2-chloro-4-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3-yl)acetate;
lt) 3- {4- [4-(2-thienylcarbonyl)piperazin-1-yl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
lu) ((3R)-1- {4- [2-(2-chloro-4-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}piperidin-3-yl)acetic acid;
lv) 3- {4-[4-(4-methoxybenzoyl)piperazin-1-yl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
l w) 3- [3-(3-morpholin-4-ylpiperidin-1-yl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
lx) N,N-dipropyl-1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-amine;
ly) N-(cyclohexylmethyl)-1- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-amine;
lz) N-phenyl-1- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-amine;
ma) 3- [3-(4-morpholin-4-ylpiperidin-1-yl)phenyl]-2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
mb) N-ethyl-N-methyl-i- {3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-amine;
mc) N-(2-phenylethyl)-1- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-amine;
md) N-butyl-1- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }piperidin-4-amine;
me) 3- {3-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
mf) N-(cyclohexylmethyl)-1- {3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-amine;
mg) N-phenyl-1- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-amine;
mh) 1- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-ol;
ml) N-(1 H-indol-5-ylmethyl)-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
mm) {3-[2-(2,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amine; inn) N-[(1-methyl-i H-indol-5-yl)methyl]-3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
mo) 3-(4-bromophenyl)-2-(2,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
mp) 3-(4-bromophenyl)-2-(2,6-dichlorobenzyl)-7-(trifluoromethyl)-2H-indazole;
mq) methyl ((3 R)-1- {4-[2-(2,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }piperidin-3-yl)acetate;
mr) methyl ((3 R)-1- {4-[2-(2,6-dichlorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }piperidin-3-yl)acetate;
ms) ((3R)-1- {4-42-(2,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3-yl)acetic acid;
mt) ((3R)-1- {4-[2-(2,6-dichlorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3-yl)acetic acid;
mu) 3-(3-bromophenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
my) {3-[2-(2,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }[(1-methyl-i H-indol-2-yl)methyll amine;
mw) 3-(3-ethynylphenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
my) N-(2-fluoro-4-methoxybenzyl)-3-[2-(2,4,6-trifluorobenzyl)-7(trifluoromethyl)-2H-indazol-3-yl]aniline;
mz) N- [2-fluoro-5-(trifluoromethyl)benzyl]-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
na) N-(2,5-dimethylbenzyl)-3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]aniline;
nb) N- [2-fluoro-3-(trifluoromethyl)benzyl]-3- [2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
nc) N-(2,5-dimethylbenzyl)-4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]aniline;
nd) N-[2-fluoro-5-(trifluoromethyl)benzyl]-4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
ne) (3 R)-1-(2,4-dimethoxybenzoyl)-N- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
nf) N-(1 H-indol-4-ylmethyl)-3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
ng) N- [(3-methyl-i -benzothien-2-yl)methyl]-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
nh) N-(pyridin-4-ylmethyl)-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl7janiline;
ni) N-(pyridin-2-ylmethyl)-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]aniline;
nj) N-(pyridin-3-ylmethyl)-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]aniline;
nk) N-(1 H-indol-7-ylmethyl)-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
nl) N-[(3-methyl-2-thienyl)methyl]-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
nm) N- [(5-methyl-2-thienyl)methyl]-3-[2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
nn) N- [(4-bromo-2-thienyl)methyl]-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
no) N-[(5-bromo-2-thienyl)methyl]-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
np) N- [(5-chloro-2-thienyl)methyl]-3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
nq) ethyl 3-({3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)benzoate;
nv) ethyl 3-(2- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }ethyl)benzoate;
nw) 3-({3-[2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}ethynyl)benzoic acid;
nz) 3-(2- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}ethyl)benzoic acid;
of) N-methyl-3-({3-L2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)benzamide;
og) 3-(3- {[3-(morpholin-4-ylcarbonyl)phenyl]ethynyl }phenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
oh) tert-butyl 4- [3-({3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)benzoyl]piperazine-1-carboxylate;
oi) N-methyl-3-(2- {3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }ethyl)benzamide;
oj) 3-(3- {2-[3-(morpholin-4-ylcarbonyl)phenyl]ethyl }phenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ok) tert-butyl 4-[3-(2- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethyl)benzoyl]piperazine-1-carboxylate;
ol ) N- [(1-ethyl-i H-indol-5-yl)methyl]-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
om) N-[(1-propyl-1 H-indol-5-yl)methyl]-3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
on) N-[(1-butyl-1 H-indol-5-yl)methyl]-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
oo) N-[(1-isopropyl-1 H-indol-5-yl)methyl]-3- [2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
op) N- [(1-sec-butyl-1 H-indol-5-yl)methyl]-3- [2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
oq) N-[(2-methyl-1 H-imidazol-5-yl)methyl]-3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]aniline;
or) N-(2-naphthylmethyl)-3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-y17J aniline;
os) 3- {3-[(2,5-dichlorophenyl)ethynyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ot) 3- {3- [(2,4-dichlorophenyl)ethynyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ou) 3- {3-[2-(2,4-dichlorophenyl)ethyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ov) 2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-3-(3- {[2-(trifluoromethyl)phenyl]ethynyl ) phenyl)-2H-indazole;
ow) 2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-3-(3- {2-[2-(trifluoromethyl)phenyl]ethyl }phenyl)-2H-indazole;
oz) 3- {3- [2-(2 ,5-dichlorophenyl)ethyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pa) 3- [3-(2-phenylethyl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pd) 3-(3- {[2-chloro-5-(trifluoromethyl)phenyl]ethynyl }phenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pe) 3- {3- [(2-bromo-5-fluorophenyl)ethynyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pf) 3-(3- {2-[2-chloro-5-(trifluoromethyl)phenyl]ethyl }phenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pg) 3- {3-[2-(2-bromo-5-fluorophenyl)ethyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ph) 3- {3-[2-(3-fluorophenyl)ethyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pi) 4-amino-3-({3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }ethynyl)benzonitrile;
pj) 3- {3-[(3-chloro-2-fluorophenyl)ethynyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pk) [3-({3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}ethynyl)phenyl]methanol;
pl ) 4-amino-3-(2- {3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethyl)benzonitrile;
pm) 3- {3- [(2,3-dichlorophenyl)ethynyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
px) 3- {3- [2-(2,3-dichlorophenyl)ethyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
py) 3- {3-[2-(3-chloro-2-fluorophenyl)ethyl]phenyl }-2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pz) [3-(2- {3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}ethyl)phenyl]methanol;
qa) 3-(4-ethynylphenyl)-2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole; qb) ethyl 3-({4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)benzoate;
qc) 3-({4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)benzoic acid;
qd) N-[3-({3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)phenyl]morpholine-4-carboxamide;
qe) tert-butyl 4-({[3-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)phenyl]amino }carbonyl)piperazine-1-carboxylate;
qf) 2-methyl-N-[3-({3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}ethynyl)phenyl]piperidine-1-carboxamide;
qg) 3-methyl-N-[3-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)phenyl]piperidine-1-carboxamide;
qh) 4-methyl-N-[3-({3 .-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)phenyl]piperidine-1-carboxamide;
qi) 3-(hydroxymethyl)-N-[3-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)phenyl]piperidine-1-carboxamide;
qj) N-isopropyl-N′- [3-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)phenyl]urea;
qk) N,N-dipropyl-Nt-[3-({3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)phenyl]urea;
ql) N-methyl-N′-[3-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)phenyl]urea;
qm) N,N-dimethyl-N′-[3-({3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yllphenyl}ethynyl)phenyllurea;
qn) 3-(4- {[2-chloro-5-(trifluoromethyl)phenyl]ethynyl }phenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
qo) 3- {4-[(2,4-difluorophenyl)ethynyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
qp) 3- {4-[(3 ,5-dimethylphenyl)ethynyl]phenyl }-2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
qq) 3- {4- [(3-chloro-2-fluorophenyl)ethynyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
qr) 3- {4- [(2,3-dichlorophenyl)ethynyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
qs) 3- {4-[(2,3-dimethylphenyl)ethynyl]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
qt) tert-butyl 4- [3-({4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}ethynyl)benzoyl]piperazine-1-carboxylate;
qu) 3-(3-bromophenyl)-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
qv) 1-methyl-3-[3-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)phenyl]imidazolidin-2-one;
qw) methyl [3-({3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }ethynyl)phenyl]carbamate;
qx) N-(methylsulfonyl)-N-[3-({3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)phenyl]methanesulfonamide;
qy) 3-[3-(pyridin-3-ylethynyl)phenylll-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
qz) 3- [3-(pyridin-4-ylethynyl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ra) 6-methyl-2-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl}ethynyl)pyridin-3-ol;
rb) 3- [3-(pyridin-2-ylethynyl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
rc) 2-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}ethynyl)pyridin-3-ol;
rf) tert-butyl 6-methyl-5- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-1 H-indole-1-carboxylate;
rg) tert-butyl 6-fluoro-5- {3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-1 H-indole-1-carboxylate;
rh) 5- {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-3 ,4-dihydronaphthalen-1 (2H)-one;
ri) 3-(3-bromophenyl)-2-(2-chloro-4-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
rj) 3- {3-[4-(morpholin-4-ylsulfonyl)phenoxy]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
rk) 3- {3-[4-(pyrrolidin-1-ylsulfonyl)phenoxy]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
rl) N-propyl-4- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}benzenesulfonamide;
rm) N-ethyl-N-methyl-4- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}benzenesulfonamide;
rn) N,N-diethyl-4- {3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}benzenesulfonamide;
ro) 3- {3- [4-(piperidin-1-ylsulfonyl)phenoxy]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
rp) N,N-dimethyl-4- {3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}benzenesulfonamide;
rq) 4-fluoro-2-({3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenyl }ethynyl)aniline;
rr) 4-chloro-2-fluoro-6-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}ethynyl)aniline;
rs) methyl [4-fluoro-2-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }ethynyl)phenyl]carbamate;
rt) 3- [3-(5-fluoro-1 H-indol-2-yl)phenyl]-2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ru) 3- [3-(5-fluoro-1-methyl-i H-indol-2-yl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
tx) [3-({4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yllphenyl }amino)phenyl]acetic acid;
ue) [3-({4- [2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]acetic acid;
uf) [3-({4-[2-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }arnino)phenyllacetic acid;
ug) {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}(phenyl)acetic acid;
ui) 2-(4-chloro-2-fluorobenzyl)-3-[3-(4-methoxybenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
uj) 2-(4-chloro-2-fluorobenzyl)-3-[3-(3 ,5-dimethoxybenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
uk) 2-(4-chloro-2-fluorobenzyl)-3-[3-(3 ,5-dimethylbenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
ul) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(2,3-dimethylphenoxy)methyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
um)2-(4-chloro-2-fluorobenzyl)-3-(3- {[2-chloro-5-(trifluoromethyl)phenoxy]methyl }phenyl)-7-(trifluoromethyl)-2H-indazole;
un) 2-(4-chloro-2-fluorobenzyl)-3-(3- {[2-chloro-3-(trifluoromethyl)phenoxy]rnethyl }phenyl)-7-(trifluoromethyl)-2H-indazole;
uo) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(1-naphthyloxy)methyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
up) 3- {3-[(2-tert-butyl-5-rnethylphenoxy)rnethyl]phenyl }-2-(4-chloro-2-fluorobenzyl)-7-(trifluorornethyl)-2H-indazole;
ur) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(4-fluoro-2-methylphenoxy)rnethyl]phenyl }-7-(trifluorornethyl)-2H-indazole;
us) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2,6-dimethylphenoxy)methyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
ut) 5-({3- [2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]benzyl }oxy)-3 ,4-dihydronaphthalen-1 (2H)-one;
uu) 2-(4-chloro-2-fluorobenzyl)-3-[3-(2-methoxybenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
uv) 2-(4-chloro-2-fluorobenzyl)-3-[3-(3-methoxybenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
uw) 2-(4-chloro-2-fluorobenzyl)-3-[3-(2,3-dimethoxybenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
ux) 2-(4-chloro-2-fluorobenzyl)-3-(3- {[(3,3-dimethyl-2,3-dihydro-1 -benzofuran-7-yl)oxy]methyl }phenyl)-7-(trifluoromethyl)-2H-indazole;
uy) 3- {3- [(2-tert-butylphenoxy)methyl]phenyl }-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
uz) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(2,3-dimethoxyphenoxy)methyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
va) 2-(4-chloro-2-fluorobenzyl)-3-[3-(3 ,4-dimethoxybenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
vb) 2-(4-chloro-2-fluorobenzyl)-3-[3-(4-chloro-2-fluorobenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
vc) 2-(4-chloro-2-fluorobenzyl)-3-[3-(2-chloro-4-fluorobenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
vd) 2-(4-chloro-2-fluorobenzyl)-3- {3- [2-fluoro-4-(trifluoromethyl)benzyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
ve) 3- {3-[2,4-bis(trifluoromethyl)benzyl]phenyl }-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
vf) 2-(4-chloro-2-fluorobenzyl)-3-[3-(2,4-difluorobenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
vg) 3- {3-[2,5-bis(trifluoromethyl)benzyl]phenyl }-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
vh) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2,6-dichlorophenoxy)methyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
vi) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(2,6-dimethoxyphenoxy)methyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
vj) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2,6-dibromophenoxy)methyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
vk) 2-(4-chloro-2-fluorobenzyl)-3-[3-(2-fluoro-3-methylbenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
vl) 2-(4-chloro-2-fluorobenzyl)-3-[3-(6-chloro-2-fluoro-3-methylbenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
vm) 3- {3-[(2-allyl-6-methylphenoxy)methyl]phenyl }-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
vn) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(2,6-diisopropylphenoxy)methyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
vo) 3- {3-[(2-tert-butyl-6-methylphenoxy)methyl]phenyl }-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
vp) 3- {3-[(2-allyl-6-methoxyphenoxy)methyl]phenyl }-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
vq) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2,5-dichlorophenoxy)methyllphenyl }-7-(trifluoromethyl)-2H-indazole;
vr) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2,6-difluorophenoxy)methyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
vs) 2-(4-chloro-2-fluorobenzyl)-3- {3-[3-(difluoromethoxy)benzyllphenyl }-7-(trifluoromethyl)-2H-indazole;
vt) 2-(4-chloro-2-fluorobenzyl)-3-[3-(2-phenylethyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
vu) 3-({3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)-N-propylbenzamide;
vv) N-benzyl-3-({3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}methyl)benzamide;
vw) 3-({3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)-N-cyclopropylbenzamide;
vx) 2-(4-chloro-2-fluorobenzyl)-3-(3- {[3-(morpholin-4-ylcarbonyl)benzyl]oxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
vy) 3-({3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -ylllphenoxy}methyl)-N-isopropylbenzamide;
xs) 2-(2,4-dimethylbenzyl)-3- {3-[(2,6-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
xt) 3- {3-[(2,6-dimethylbenzyl)oxy]phenyl }-2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
xu) 3- {3-[(2-fluoro-6-nitrobenzyl)oxy]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
yo) 2-(2,4-difluorobenzyl)-3- {3- [(2,6-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
yp) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(2,6-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
yq) 2-(2-chloro-4-fluorobenzyl)-3- {3-[(2,6-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
yt) 2-(2,4-dichlorobenzyl)-3- {3-[(2,6-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
za) 2-[4-({3-[2-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}methyl)phenyl]-2-methylpropanoic acid;
zb) 2-methyl-2-[4-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]propanoic acid;
zc) 2- [4-({3- [2-(2 ,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}methyl)phenyl]propanoic acid;
zd) 2-[4-({3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}methyl)phenyl]propanoic acid;
ze) 2-(2,4-dimethylbenzyl)-3- {3-[(2-fluoro-6-nitrobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
zf) 3-({3-[2-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)benzonitrile;
zg) 3-[3-(benzyloxy)phenyl]-2-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazole;
zh) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(2-fluoro-6-nitrobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
zi) 3-({3- [2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)benzonitrile;
zj) 2- {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-2-(4-methylphenyl)propanoic acid;
abk) 2-(4-chloro-2-fluorobenzyl)-3- {3- [2-chloro-5-(trifluoromethyl)benzyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
abl) 2-(4-chloro-2-fluorobenzyl)-3- {3-[4-(methylsulfonyl)benzyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
abm) 2-(4-chloro-2-fluorobenzyl)-3- {3-[2-methyl-5-(trifluoromethyl)benzyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
abn) 2-(4-chloro-2-fluorobenzyl)-3-[3-(2-chloro-5-fluorobenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
abo) 2-(4-chloro-2-fluorobenzyl)-3- {3- [5-fluoro-2-(trifluoromethyl)benzyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
abp) 2-(4-chloro-2-fluorobenzyl)-3-[3-(2,5-dichlorobenzyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
abq) 2-(4-chloro-2-fluorobenzyl)-3- {3- [5-chloro-2-(trifluoromethyl)benzyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
abr) 2-(4-chloro-2-fluorobenzyl)-3- {3-[3-(morpholin-4-ylcarbonyl)benzyl]phenyl 1-7-(trifluoromethyl)-2H-indazole;
abs) N-benzyl-3- {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]benzyl }benzamide;
abt) 2-(4-chloro-2-fluorobenzyl)-3- {3-[3-(pyrrolidin-1-ylcarbonyl)benzyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
abu) 2-(4-chloro-2-fluorobenzyl)-3- {3-[3-(piperidin-1-ylcarbonyl)benzyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
abv) 2-(4-chloro-2-fluorobenzyl)-3-[3-(3-chlorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
abw) 2-(4-chloro-2-fluorobenzyl)-3-[3-(2-fluorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
abx) 6- {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-2-naphthonitrile;
aby) 2-(4-chloro-2-fluorobenzyl)-3-[3-(5 ,6,7,8-tetrahydronaphthalen-1-yloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
abz) 2-(4-chloro-2-fluorobenzyl)-3-[3-(2-ethoxyphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aca) 1-(2- {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yllphenoxy}phenyl)propan-1-one;
acb) 3- {3- [2-(1 H-benzimidazol-2-yl)phenoxy]phenyl }-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
acc) 2-(4-chloro-2-fluorobenzyl)-3-[3-(2-pyrrolidin-1-ylphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
acd) 3- {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]benzyl }-N,N-diethylbenzamide; ace) 3- {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yllbenzyl }-N-cyclopropylbenzamide;
acf) 3- {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]benzyl }-N-isopropylbenzamide;
acg) 3- {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]benzyl }-N-propylbenzamide;
ach) 3- {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]benzyl }-N-ethylbenzamide;
aci) 3- {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]benzyl }-N-methylbenzamide;
acm) 2- [4-({3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]-2-methylpropanoic acid;
acn) 2-(2,4-difluorobenzyl)-3- {4-[(2,6-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aco) 2-(2,4-dichlorobenzyl)-3- {4-[(2,6-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
acp) 2-(4-chloro-2-fluorobenzyl)-3- {4-[(2,6-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
acq) 2-(2-chloro-4-fluorobenzyl)-3- {4- [(2,6-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
acr) 2-(2,4-dimethylbenzyl)-3- {4-[(2,6-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
acv) 2-(4-chloro-2-fluorobenzyl)-3- {3-{(2,5-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
acw) 2-(2,4-dimcthylbenzyl)-3- {3-[(2,5-dimethylbcnzyl)oxy]phenyl }-7-(trifluoromcthyl)-2H-indazole;
adb) 2-(2-chloro-4-fluorobenzyl)-3- {4-[(2,5-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
adc) 2-(2,4-dichlorobenzyl)-3- {4-[(2 ,5-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
add) 3- {3-[(2,5-dimethylbenzyl)oxy]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
adq) 2-(4-chloro-2-fluorobenzyl)-3- {4-[(2,5-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
adr) 2-(2,4-dimethylbenzyl)-3- {4-[(2,5-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
ads) 3- {4-[(2,5-dimethylbenzyl)oxy]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
adt) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2-methyl-3-nitrobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
adu) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(5-methyl-2-nitrobenzyl)oxylphenyl }-7-(trifluoromethyl)-2H-indazole;
adv) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2-chloro-5-nitrobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
adw) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2-fluoro-3-methylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
adx) 2-(4-chloro-2-fluorobenzyl)-3-(3- {[5-fluoro-2-(trifluoromethyl)benzyl]oxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
ady) 2-(4-chloro-2-fluorobenzyl)-3-(3- {[2-chloro-3-(trifluoromethyl)benzyl]oxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
adz) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2-methoxy-5-nitrobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aea) 2-(4-chloro-2-fluorobenzyl)-3-(3- {[2-methyl-5-(trifluoromethyl)benzyl]oxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
aeb) 3- {3-[(2-bromo-5-methoxybenzyl)oxy]phenyl }-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aec) 3-(3- {[2,5-bis(trifluoromethyl)benzyl]oxy}phenyl)-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aed) 1- [3-({3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}methyl)-4-methoxyphenyl]ethanone;
aee) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2,5-difluorobenzyl)oxy]phenyl)-7-(trifluoromethyl)-2H-indazole;
aef) 3- {3- [(2-bromo-5-fluorobenzyl)oxy]phenyl }-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aeg) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(3-chloro-2-fluorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aeh) 2-(4-chloro-2-fluorobenzyl)-3-(3- {[2-fluoro-5-(trifluoromethyl)benzyl]oxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
aei) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(2,3 ,6-trifluorobenzyl)oxylphenyl }-7-(trifluoromethyl)-2H-indazole;
aej) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2,5-dichlorobenzyl)oxy]phenyl}-7-(trifluoromethyl)-2H-indazole;
aek) 2-(4-chloro-2-fluorobenzyl)-3-(3- {[2-chloro-5-(trifluoromethyl)benzyl]oxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
ael) 2-(4-chloro-2-fluorobenzyl)-3-(3- {[5-chloro-2-(trifluoromethyl)benzyl]oxy) phenyl)-7-(trifluoromethyl)-2H-indazole;
aem) [4-({3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]acetic acid;
aen) methyl [4-({3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}methyl)phenyl]acetate;
aeo) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(6-chloro-2-fluoro-3-methylbenzyl)oxy]phenyl}-7-(trifluoromethyl)-2H-indazole;
aep) 3- {3-[(2-chloro-3 ,6-difluorobenzyl)oxy]phenyl }-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aeq) 3- {3-[(3-chloro-2,6-difluorobenzyl)oxy]phenyl }-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aer) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(5-chloro-2-fluorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aes) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2,5-dimethoxybenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aet) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(5-fluoro-2-methylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aeu) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(2,6-difluoro-3-methylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aev) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2,6-difluorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aew) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(2-chloro-6-fluorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aex) 2-(4-chloro-2-fluorobenzyl)-3-(3- {[2-methoxy-5-(trifluoromethoxy)benzyl]oxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
aey) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(2,3-dimethoxybenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aez) 3-[3-(benzyloxy)phenyl]-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
afa) 2-(4-chloro-2-fluorobenzyl)-3- {3-[(4-methylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
afb) 2-(4-chloro-2-fluorobenzyl)-3- {3- [(2-chloro-5-fluorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
afc) 2-(2,4-dimethylbenzyl)-3-(3- {[5-fluoro-2-(trifluoromethyl)benzyl]oxy}phenyl)-7-(trifluoromethyl)-2H-indazole; afe)2-(4-chloro-2-fluorobenzyl)-3- {3-[(2-chloro-6-fluoro-3-methylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
afg) {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}(phenyl)acetic acid;
afh) 2- {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-2-phenylpropanoic acid;
afi) {3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}(3-methylphenyl)acetic acid;
afj) [4-({3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)-2,5-dimethylphenyl]acetic acid;
afk) [4-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]acetic acid;
afl) 1- [4-({3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyllcyclopropanecarboxylic acid;
afm) 3-(3- {[5-fluoro-2-(trifluoromethyl)benzyl]oxy}phcnyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
afn) [3-({3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)-2,4-dimethylphenyl]acetic acid;
afo) [4-({3-[2-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phcnyl]acetic acid;
afp) 3,3 ′-[methylenebis(oxy-3 ,1-phenylcne)]bis[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole];
afq) 2-[3-({4-[2-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]-2-methylpropanoic acid;
afr) 3-(3- {[5-chloro-2-(trifluoromethyl)benzyl]oxy}phenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
afs) 3-(3- {[2-chloro-5-(trifluoromethyl)benzyl]oxy}phenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aft) 2-(4-chloro-2-fluorobenzyl)-3-[3-(2-phenylethyl)phenyl]-7-(trifluoromethyl)-2H-indazole;
afu) 2-(4-chloro-2-fluorobenzyl)-3- {3-[2-(2,5-dimethylphenyl)ethyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
afv) 2-(4-chloro-2-fluorobenzyl)-3- {3-[2-(2,5-dichlorophenyl)ethyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
afw) 2-(4-chloro-2-fluorobenzyl)-3- {3-[2-(2,5-difluorophenyl)ethyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
afx) 2-(4-chloro-2-fluorobenzyl)-3- {3-[2-(5-chloro-2-fluorophenyl)ethyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
afy) 2-(4-chloro-2-fluorobenzyl)-3- {3- [2-(2-chloro-5-fluorophenyl)ethyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
afz) 2-(4-chloro-2-fluorobenzyl)-3-(3- {2-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl }phenyl)-7-(trifluoromethyl)-2H-indazole;
aga) 2-(4-chloro-2-fluorobenzyl)-3-(3- {2-[3 (trifluoromethoxy)phenyl]ethyl }phenyl)-7-(trifluoromethyl)-2H-indazole;
agb) 2-(4-chloro-2-fluorobenzyl)-3- {3-[2-(3-methoxyphenyl)ethyl]phenyl}-7-(trifluoromethyl)-2H-indazole;
agc) 2-(4-chloro-2-fluorobenzyl)-3-(3- {2- [3-(difluoromethoxy)phenyl]ethyl }phenyl)-7-(trifluoromethyl)-2H-indazole;
agd) 2-(4-chloro-2-fluorobenzyl)-3-(3- {2- [2-methyl-5-(trifluoromethyl)phenyl]ethyl }phenyl)-7-(trifluoromethyl)-2H-indazole;
age) 3-(3- {2-[2,5-bis(trifluoromethyl)phenyl]ethyl }phenyl)-2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
agf) 2-(4-chloro-2-fluorobenzyl)-3- {3-[2-(2,3-dimethoxyphenyl)ethyl]phenyl 1-7-(trifluoromethyl)-2H-indazole;
agg) 2-(4-chloro-2-fluorobenzyl)-3-(3- {2-[2-chloro-5-(trifluoromethyl)phenyl]ethyl }phenyl)-7-(trifluoromethyl)-2H-indazole;
agh) 2-(4-chloro-2-fluorobenzyl)-3-(3- {2-[5-chloro-2-(trifluoromethyl)phenyl]ethyl }phenyl)-7-(trifluoromethyl)-2H-indazole;
agi) 2-(4-chloro-2-fluorobenzyl)-3-(3- {2-[5-fluoro-2-(trifluoromethyl)phenyl]ethyl) phenyl)-7-(trifluoromethyl)-2H-indazole;
agy) 2-(2,4-dimethylbenzyl)-3-[4-(2-methoxyphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
agz) 3-[4-(2-methoxyphenoxy)phenyl]-2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aha) 2-(4-chloro-2-fluorobenzyl)-3- [4-(2-methoxyphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
ahb) (3- {4-112-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)dimethylamine;
ahd) N,N-dimethyl-3- {4-112-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}aniline;
ahe) (3- {4- [2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)dimethylamine;
ahf) 3- {4-[2-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3-yllphenoxy}-N-methoxy-N-methylbenzamide;
ahg) N-methoxy-N-methyl-3- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}benzamide;
ahh) 3- {4- [2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-N-methoxy-N-methylbenzamide;
ahi) 5- {4-L2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-3 ,4-dihydronaphthalen-1 (2H)-one;
ahl) 3- {4-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}benzaldehyde;
ahm) 2-(4-chloro-2-fluorobenzyl)-3-[4-(5,6,7,8-tetrahydronaphthalen-1-yloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
ahn) 5- {4- [2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-1,2,3 ,4-tetrahydronaphthalen-1-ol;
ahp) 3- {4-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-N,N-dimethylbenzamide;
ahq) 3- {4-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-N,N-diethylbenzamide;
ahr) 2-(4-chloro-2-fluorobenzyl)-3- {4-[3-{pyrrolidin-1-ylcarbonyl)phenoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
ahs) 2-(4-chloro-2-fluorobenzyl)-3- {4-[3-(piperidin-1-ylcarbonyl)phenoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aht) 2-(4-chloro-2-fluorobenzyl)-3- {4-[3-(morpholin-4-ylcarbonyl)phenoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
ahv) 1-(3- {4-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}phenyl)ethanone;
ahw) N,N-dimethyl-3- {4-[2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}benzamide;
ahx) 3- {4-[2-(2,4-dimethylbenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-N,N-dimethylbenzamide;
ahy) 2-(3- {4- [2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}phenyl)propan-2-ol;
aia) (1 S)-5- {4- [2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}-1,2,3 ,4-tetrahydronaphthalen-1-01;
aib) (1 R)-5- {4- [2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}-1 ,2,3 ,4-tetrahydronaphthalen-1-ol;
aid) 3- {4-[3-(piperidin-1-ylcarbonyl)phenoxy]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aie) 2-(3- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)propan-2-ol;
aif) 3- {4-[3-(morpholin-4-ylcarbonyl)phenoxy]phenyl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aig) 5- {3-[2-(2-chloro-4-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-3 ,4-dihydronaphthalen-1 (2H)-one;
aih) 2-(2-chloro-4-fluorobenzyl)-3-(4-methoxyphenyl)-7-(trifluoromethyl)-2H-indazole;
aii) 2-(4-chloro-2-fluorobenzyl)-3-(4-methoxyphenyl)-7-(trifluoromethyl)-2H-indazole;
aij) 3-(4-methoxyphenyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aik) 5- {3-[2-(2-chloro-4-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}quinoline;
ail) 5- {3-[2-(2-chloro-4-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}isoquinoline;
aim) 4- {3-[2-(2-chloro-4-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}quinazoline;
ain) 6- {3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-3 ,4-dihydronaphthalen-1 (2H)-one;
aio) 2-(2-chloro-4-fluorobenzyl)-3-[3-(5,6,7,8-tetrahydronaphthalen-2-yloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aip) 2-(2-chloro-4-fluorobenzyl)-3-[3-(5 ,6,7,8-tetrahydronaphthalen-1-yloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aiq) 2- {4-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }-1 H-indole-5-carbonitrile;
air) 3- [4-(5-fluoro-1 H-indol-2-yl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ais) 5- {3-112-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-3 ,4-dihydronaphthal en-i (2H)-one;
ait) 6- {3-[2-(2-chloro-4-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-3 ,4-dihydronaphthalen-1 (2H)-one;
aiu) 3- [3-(5-bromo-6-methyl-1 H-indol-2-yl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aiv) 3- [4-(5-bromo-6-methyl-1 H-indol-2-yl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aiw) 1-methyl-2- {4-2-(2,4,6-trifluorobenzy1)-7-(trifluoromethyl)-2H-indazo1-3-yl]phenyl}-1 H-indole-5-carbonitrile;
aix) 3-[4-(5-fluoro-1-methyl-i H-indol-2-yl)phenyl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
aiy) 6- {3- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-3 ,4-dihydronaphthalen-1 (2H)-one;
aiz) 2- {4- [2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }-1 H-indole-5-carbonitrile;
aja) 3-[4-(5-fluoro-1 H-indol-2-yl)phenyl]-2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ajb) 5- {3-[2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-3 ,4-dihydronaphthal en-i (2H)-one;
ajc) 6- {3- [2-(2-chloro-4-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-3 ,4-dihydronaphthal en-i (2H)-one;
ajd) methyl (5- {3-{2-(2-chloro-4-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}-1-hydroxy-1,2,3 ,4-tetrahydronaphthalen-1-yl)acetate;
aje) ethyl [4-({3-[2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]acetate;
ajf) (5- {3-[2-(2-chloro-4-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-3 ,4-dihydronaphthalen-1-yl)acetic acid;
ajg) ethyl [4-({4-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]phenoxy}methyl)phenyl]acetate; and
ajh) 5- {3- [2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-1 ,2,3,4-tetrahydronaphthalen-l -ol; or a pharmaceutically acceptable salt thereof.
31. A pharmaceutical composition which comprises a compound of claim 1 , or a pharmaceutically acceptable salt thereof and a pharmaceutical carrier.
32. The compound of claim 1 , wherein the compound is selected from the group consisting of:
h) 2-Benzyl-3-phenyl-7-methyl-2H-indazole;
dv) 7-fluoro-2-(4-fluorobenzyl)-3-(4-fluorophenyl)-2H-indazole;
dw) 7-fluoro-2-(2-fluorobenzyl)-3-(4-fluorophenyl)-2H-indazole;
dx) 2-(4-chlorobenzyl)-7-fluoro-3-(4-fluorophenyl)-2H-indazole;
dy) 2-(2,4-difluorobenzyl)-7-fluoro-3-(4-fluorophenyl)-2H-indazole;
dz) 2-(3 ,4-difluorobenzyl)-7-fluoro-3-(4-fluorophenyl)-2H-indazole;
ea) 2-benzyl-3-(2,4-dimethoxyphenyl)-7-fluoro-2H-indazole;
eb) 3-(2,4-dimethoxyphenyl)-7-fluoro-2-(2-fluorobenzyl)-2H-indazole;
ec) 3-(2,4-dimethoxyphenyl)-7-fluoro-2-(4-fluorobenzyl)-2H-indazole;
ed) 2-(2-chloro-6-fluorobenzyl)-3-(2,4-dimethoxyphenyl)-7-fluoro-2H-indazole;
ef) methyl 2-(2,4-dimethylbenzyl).-3-(4-fluorophenyl)-2H-indazole-7-carboxylate;
eg) 2-benzyl-7-fluoro-3-(4-methoxy-2.-methylphenyl)-2H-indazole;
eh) 7-fluoro-2-(2-fluorobenzyl)-3-(4-methoxy-2-methylphenyl)-2H-indazole;
ei) 7-chloro-2-(2-fluorobenzyl)-3-(4-methoxy-2-methylphenyl)-2H-indazole;
ej) [2-(2,4-dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazol-7-yl]methanol;
ek) 7-fluoro-2-(4-fluorobenzyl)-3-(4-methoxy-2-methylphenyl)-2H-indazole;
el) 2-(2-chloro-6-fluorobenzyl)-7-fluoro-3-(4-methoxy-2-methylphenyl)-2H-indazole;
em) 2-(2,4-dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazole-7-carboxylic acid;
en) 2-(4-chlorobenzyl)-3-(2,4-dimethoxyphenyl)-7-fluoro-2H-indazole;
eo) 2-(3 ,4-difluorobenzyl)-3-(2,4-dimethoxyphenyl)-7-fluoro-2H-indazole;
ep) 2-benzyl-7.-chloro-3-(2,4-dimethoxyphenyl)-2H-indazole;
eq) 7-chloro-3-(2,4-dimethoxyphenyl)-2-(4-fluorobenzyl)-2H-indazole;
er) 7-chloro-3-(2,4-dimethoxyphenyl)-2-(2-fluorobenzyl)-2H-indazole;
es) 7-chloro-2-(4-fluorobenzyl)-3-(4-methoxy-2-methylphenyl)-2H-indazole;
et) 2-(2,4-difluorobenzyl)-7-fluoro-3-(4-methoxy-2-methylphenyl)-2H-indazole;
eu) 2-(2-chlorobenzyl)-3-(2,4-dimethoxyphenyl)-7-fluoro-2H-indazole;
ew) 2-(2,4-difluorobenzyl)-3-(2,4-dimethoxyphenyl)-7-fluoro-2H-indazole;
ex) 2-(2-chlorobenzyl)-7-fluoro-3-(4-methoxy-2-methylphenyl)-2H-indazole;
ey) 7-chloro-2-(4-fluorobenzyl)-3-(4-fluorophenyl)-2H-indazole;
ez) 7-chloro-2-(2-fluorobenzyl)-3-(4-fluorophenyl)-2H-indazole;
fa) 7-chloro-2-(4-chlorobenzyl)-3-(4-fluorophenyl)-2H-indazole;
fb) 7-chloro-2-(2,4-difluorobenzyl)-3 .-(4-fluorophenyl)-2H-indazole;
fc) 7-chloro-2-(3 ,4-difluorobenzyl)-3-(4-fluorophenyl)-2H-indazole;
fe) 1-[2-(2,4-difluorobenzyl)-3-(4-fluorophenyl)-2H-indazol-7-yl]piperidine-4-carboxamide;
fg) 2-(2,4-difluorobenzyl)-3-(4-fluorophenyl)-7-morpholin-4-yl-2H-indazole;
fh) 2-(2,4-difluorobenzyl)-3-(4-fluorophenyl)-7-piperidin-1-yl-2H-indazole;
fi) 2-(2,4-difluorobenzyl)-3-(4-fluorophenyl)-N,N-dimethyl-2H-indazol-7-amine;
lj) 2-(2,4-difluorobenzyl)-N-ethyl-3-(4-fluorophenyl)-2H-indazol-7-amine;
fk) 2-(2,4-difluorobenzyl)-3-(4-fluorophenyl)-7-pyrrolidin-1-yl-2H-indazole;
fh) 2-(2,4-difluorobenzyl)-3-(4-fluorophenyl)-2H-indazole-7-carbonitrile;
fr) 7-chloro-2-(2-chloro-6-fluorobenzyl)-3-(4-fluorophenyl)-2H-indazole;
fs) 7-chloro-2-(2-chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-2H-indazole;
ft) 7-chloro-2-(2,4-dichlorobenzyl)-3-(4-fluorophenyl)-2H-indazole;
fu) 7-chloro-2-.(2,6-difluorobenzyl)-3-(4-fluorophenyl)-2H-indazole;
fv) 7-chloro-3-(4-fluorophenyl)-2-(2,4,6-trifluorobenzyl)-2H-indazole; and
fw) 7-chloro-2-(2,4-dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazole; or a pharmaceutically acceptable salt thereof.
33. The compound of claim 1 , wherein the compound is selected from the group consisting of:
bx) 2-Benzyl-3-butyl-7-trifluoromethyl-2H-indazole;
by) 2-Benzyl-3-isobutyl-7-trifluoromethyl-2H-indazole;
bz) 2-Benzyl-3-cyclopentyl-7-trifluoromethyl-2H-indazole;
ca) 2-Benzyl-3-cyclohexanyl-7-trifluoromethyl-2H-indazole;
cg) 2-Benzyl-3-naphtalen-2-yl-7-trifluoromethyl-2H-indazole;
gx) 2-(2,4-difluorobenzyl)-3-(pyridin-2-ylmethyl)-7-(trifluoromethyl)-2H-indazole;
gy) 2-(2-chloro-4-fluorobenzyl)-3-(pyridin-2-ylmethyl)-7-(trifluoromethyl)-2H-indazole;
gz) 2-(2-chloro-6-fluorobenzyl)-3-(pyridin-2-ylmethyl)-7-(trifluoromethyl)-2H-indazole;
ha) 2-(2,6-difluorobenzyl)-3-(pyridin-2-ylmethyl)-7-(trifluoromethyl)-2H-indazo1e;
hb) 3-(pyridin-2.-ylmethyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
hc) 2-(2,6-dichlorobenzyl)-3-(pyridin-2-ylmethyl)-7-(trifluoromethyl)-2H-indazole;
hp) 2-(2,4-dichlorobenzyl)-3-pyridin-2-yl-7-(trifluoromethyl)-2H-indazole;
hq) 2-(2,6-difluorobenzyl)-3-pyridin-2-yl-7-(trifluoromethyl)-2H-indazole;
hr) 2-(2,4-difluorobenzyl)-3-pyridin-2-yl-7-(trifluoromethyl)-2H-indazole;
hs) 2-(2,4-dimethylbenzyl)-3-pyridin-2-yl-7-(trifluoromethyl)-2H-indazole;
ht) 3-pyridin-2-yl-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ju) 2-(4-chlorobenzyl)-3-pyridin-2-yl-7-(trifluoromethyl)-2H-indazole;
jv) 2-(2-chlorobenzyl)-3-pyridin-2-yl-7-(trifluoromethyl)-2H-indazole;
jw) 2-(2-chloro-4-fluorobenzyl)-3-pyridin-2-yl-7-(trifluoromethyl)-2H-indazole;
jx) 2-(2-chloro-6-fluorobenzyl)-3-pyridin-2-yl-7-(trifluoromethyl)-2H-indazole;
ks) 2-(2-methylphenyl)-3-pyridin-2-yl-7-(trifluoromethyl)-2H-indazole;
mi) N-(2,5-difluorobenzyl)-2-[2-(2 ,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]pyridin-4-amine;
mj) 2- [2-(2,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3-yl]-N-(2,5-dimethylbenzyl)pyridin-4-amine;
mk) N-(3 ,5-difluorobenzyl)-2-[2-(2,4-difluorobenzyl)-7-(trifluoromethyl)-2H-indazol-3 -yl]pyridin-4-amine;
mx) 3- [2-(2-fluoro-4-methoxyphenyl)-1 H-indol-6-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
nr) 3-(1-benzothien-2-yl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ns) 3-(2-naphthyl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
nt) 3-(1 H-indol-5-yl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
nu) 3-dibenzo[b,d]thien-4-yl-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
nx) 3-[1-(4-chlorobenzyl)-1H-indol-5-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ny) 3-(1-benzyl-1 H-indol-5-yl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
oa) 3- {1-[5-chloro-2-(trifluoromethyl)benzyl]-1 H-indol-5-yl}-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ob) 3- [1-(2,4-difluorobenzyl)-1 H-indol-5-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
oc) 3-[1-(2-fluorobenzyl)-1 H-indol-5-yl]-2-{2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
od) 3-[1-(2-chlorobenzyl)-1H-indol-5-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
oe) 3-[1-(2,4-dichlorobenzyl)-1H-indol-5-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ox) 3-[l -(2-chloro-6-fluorobenzyl)-1 H-indol-5-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
oy) 3-[l -(2 ,6-difluorobenzyl)-1 H-indol-5-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pb) 3-[1-(2,6-dichlorobenzyl)-1 H-indol-5-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pc) 3-[1-(2-chloro-4-fluorobenzyl)-1 H-indol-5-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pn) 3- {1-[5-chloro-2-(trifluoromethyl)benzyl]-1 H-indol-6-yl }-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
po) 3-(1-benzyl-1 H-indol-6-yl)-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pp) 3-[1-(2,6-dichlorobenzyl)-1 H-indol-6-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pq) 3-[1-(2-chloro-4-fluorobenzyl)-1 H-indol-6-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pr) 3-[1-(2-chlorobenzyl)-1 H-indol-6-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
ps) 3-[l -(2-chloro-6-fluorobenzyl)-1 H-indol-6-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pt) 3-[1-(2 ,6-difluorobenzyl)-1 H-indol-6-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pu) 3-[1-(2-fluorobenzyl)-1 H-indol-6-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pv) 3- [1-(2,4-difluorobenzyl)-1 H-indol-6-yl]-2-(2 ,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
pw) 3-[1-(4-chlorobenzyl)-1 H-indol-6-yl]-2-(2,4,6-trifluorobenzyl)-7-(trifluoromethyl)-2H-indazole;
rd) 2- {[3-[1-(2 ,6-dichlorobenzyl)-1 H-indol-6-yl]-7-(trifluoromethyl)-2H-indazol-2-yl]methyl}-3,5-difluorophenol;
re) 2- {[3-[1-(2-chloro-6-fluorobenzyl)-1 H-indol-6-yl]-7-(trifluoromethyl)-2H-indazol-2-yl]methyl}-3 ,5-difluorophenol;
rw) 2-benzyl-3-ethyl-7-(trifluoromethyl)-2H-indazole; or a pharmaceutically acceptable salt thereof.
34. The compound of claim 1 , wherein the compound is selected from the group consisting of:
a) 2-Benzyl-3-(4-methoxyphenyl)-7-trifluoromethyl-2H-indazole;
b) 4- [4-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenoxymethyl7j-benzoic acid;
c) 4-[4-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenoxy]-benzoic acid;
d) [4-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenyl]-phenyl-amine;
e) 3-[4-(2-Benzyl-7-trifluoromethyl-2H-indazol-.3-yl)-benzyl]-benzoic acid methyl ester;
f) 4t-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-biphenyl-4-carboxylic acid;
g) 4-[3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-benzyloxymethyl]-benzoic acid;
i) 2-Benzyl-3-(4-phenoxyphenyl)-7-trifluoromethyl-2H-indazole;
j) 3-[4-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenoxy]-benzoic acid;
k) {4-[4-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenoxy]-phenoxy}-acetic acid;
l) {4-[4-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenoxymethyl]-phenoxy}-acetic acid;
m) {3- [4-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenoxyrnethyl]-phenoxy}-acetic acid;
n) {3-[4-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenoxymethyl]-phenyl }-acetic acid;
o) 3-[4-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenoxymethyl]-benzoic acid;
p) {4-[3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-benzyloxymethyl]-phenoxy}-acetic acid;
q) {3-[3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-benzyloxymethyl]-phenoxy}-acetic acid;
r) 3-[3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-benzyloxymethyl]-benzoic acid;
s) 2-Benzyl-3-(4-methoxy-2-methylphenyl)-7-trifluoromethyl-2H-indazole;
t) 2-Benzyl-3-(2-methoxyphenyl)-7-trifluoromethyl-2H-indazole;
u) 2-Benzyl-3-o-tolyl-7-trifluoromethyl-2H-indazole;
v) 2-Benzyl-3-(2 ,4-dimethylphenyl)-7-trifluoromethyl-2H-indazole;
w) 2-Benzyl-3-biphenyl-4-yl-7-trifluoromethyl-2H-indazole;
x) 2-Benzyl-7-trifluoromethyl-3-(2-vinylphenyl)-2H-indazole;
y) 2-Benzyl-7-trifluoromethyl-3-(3-trifluoromethylphenyl)-2H-indazole;
z) 2-Benzyl-3-(4-fluorophenyl)-7-trifluoromethyl-2H-indazole;
aa) 2-Benzyl-3-(3-chlorophenyl)-7-trifluoromethyl-2H-indazole;
ab) 2-Benzyl-3-(3-methoxyphenyl)-7-trifluoromethyl-2H-indazole;
ac) Benzyl-[4-(2-benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenyl]-methylamine;
ad) 2-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenol;
ah) 2-Benzyl-3-(4-bromophenyl)-7-trifluoromethyl-2H-indazole;
ai) 2-Benzyl-3-(3-bromophenyl)-7-trifluoromethyl-2H-indazole;
aj) 4-[4-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-benzyl]-benzoic acid;
ak) 4- [3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-benzyl]-benzoic acid;
al) 3- [4-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-benzyl]-benzoic acid;
am) 3-[3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-benzyl]-benzoic acid;
an) {4-[4-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-benzyl]-phenyl }-acetic acid;
ao) {4-[3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-benzyl]-phenyl }-acetic acid;
ap) N-Benzyl-N-[4-(2-benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenyl]-amine;
aq) Benzyl-[3-(2-benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenyl]-amine;
at) Methyl3-({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)benzoate;
au) 2-Benzyl-3-[3-(benzyloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
av) [4-({3-[2-Benzyl-7-trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]acetic acid;
aw) 3-({3-[2-Benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl) benzoic acid;
ax) 4-({3-[2-Benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl) benzoic acid;
ay) [4-({3- [2-Benzyl-7-trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]propionic acid;
az) {3-[3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenoxymethyl])-phenoxy}-acetic acid;
ba) {4-[3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenoxymethyl])-phenoxy}-acetic acid;
bb) 2-Benzyl-3-phenyl-7-trifluoromethyl-2H-indazole;
cb) [3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenyl]-methanol;
cc) [3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenyl3-phenylamine;
cd) 3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-phenol;
ch) 2-Benzyl-3-(4-methoxy-3-methylphenyl)-7-trifluoromethyl-2H-indazole;
ci) 2-Benzyl-3-methylphenyl-7-trifluoromethyl-2H-indazole;
cj) 2-Benzyl-3-(2,3-dimethylphenyl)-7-trifluoromethyl-2H-indazole;
ck) 2-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-benzaldehyde;
cl) 2-Benzyl-3-(2-isopropyl-phenyl)-7-trifluoromethyl-2H-indazole;
cm) 2-Benzyl-3-(2-cyclohexyl-phenyl)-7-trifluoromethyl-2H-indazole;
cn) 2-Benzyl-3-(2-benzylphenyl)-7-trifluoromethyl-2H-indazole;
co) 2-Benzyl-3- [2-(1,1 ,2,2-tetrafluoroethoxy)-phenyl]-7-trifluoromethyl-2H-indazole;
cp) 2-Benzyl-3-(2-chloro-5-fluoro-phenyl)-7-trifluoromethyl-2H-indazole;
cq) 2-Benzyl-3-(9H-flouren-2-yl)-7-trifluoromethyl-2H-indazole;
cr) 2-Benzyl-3-(4-benzylphenyl)-7-trifluoromethyl-2H-indazole;
cs) 3-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-benzaldehyde;
ct) 2-Benzyl-3-(3-[i ,3-dioxolan-2-yl-phenyl)-7-trifluoromethyl indazole;
cu) 2-Benzyl-3-(4′-methoxy-biphenyl-4-yl)-7-trifluoromethyl indazole;
cv) 4′-(2-Benzyl-7-trifluoromethyl-2H-indazol-3-yl)-biphenyl-4-ol;
fd) 2-benzyl-3-(4-chlorophenyl)-7-(trifluoromethyl)-2H-indazole;
ff) 1- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidine-4-carboxamide;
fl) ethyl 1- {4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidine-4-carboxylate;
fm) (1- {4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-yl)methanol;
gb) (1- {4-[2-benzyl-7-{trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-3 -yl)methanol;
gc) 2-(1- {442-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidin-4-yl) ethanol;
gd) 2-benzyl-3-(4-piperidin- I -ylphenyl)-7-(trifluoromethyl)-2H-indazole;
ge) 2-benzyl-3-(4-pyrrolidin-1-ylphenyl)-7-(trifluoromethyl)-2H-indazole;
gf) 1- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-ol;
gm) 1-benzyl-N- {4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }pyrrolidin-3-amine;
go) 2-benzyl-3-(2,4-difluorophenyl)-7-(trifluoromethyl)-2H-indazole;
gw) 1- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }piperidine-4-carboxylic acid;
rv) 2-benzyl-3-(4-methoxyphenyl)-7-(trifluoromethyl)-2H-indazole;
rx) 4- [({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]benzyl }oxy)methyl]benzoic acid;
ry) N- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }-N-phenylamine;
rz) [4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]acetic acid;
sa) [4-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]acetic acid;
sb) 2-benzyl-3-[4-(benzyloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
sc) 3-[4-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]propanoic acid;
sd) 3-[4-({3-[2-benzyl-7-(trifluoromcthyl)-2H-indazol-3-yl]phenyl }amino)phenyl]propanoic acid;
se) 3- [3-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]propanoic acid;
sf) 3-[3-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]propanoic acid;
sg) 2-[4-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenoxy]-2-methylpropanoic acid;
sh) 2-[4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenoxy]-2-methylpropanoic acid;
si) 2- {4-[({4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl }propanoic acid;
sj) ethyl [4-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]acetate;
sk) methyl 3-[3-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]propanoate;
sl) methyl 3-[3-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]propanoate;
sm) methyl 2-[4-({4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenoxy]-2-methylpropano ate;
sn) methyl 2-[4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenoxy]-2-methylpropanoate;
so) methyl 2- {4- [({4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl }propanoate;
sp) 2-[4-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]propanoic acid;
sq) methyl 2- {4-[({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl}propanoate;
sr) 2- {4-[({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl }propanoic acid;
ss) methyl 3-[3-({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]butanoate;
st) methyl 3-[4-({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]butanoate;
su) methyl {4-[({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl}acetate;
sv) methyl [3-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]acetate;
sw) methyl [3-({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]acetate;
sx) 3-[3-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}amino)phenyllbutanoic acid
sy) 3-[4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]butanoic acid;
sz) [3-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]acetic acid;
ta) [3-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]acetic acid;
tb) {4- [({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl }acetic acid;
tc) 1-[4-({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]cyclopentanecarboxylic acid;
td) 2-[4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-.yl]phenoxy }methyl)phenyl]-2-methylpropanoic acid;
te) {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amine;
tf) {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amine;
tg) methyl 2-[3-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]propanoate;
th) methyl {4-[({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl }acetate;
ti) 2- [3-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]propanoic acid;
tj) {4-[({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl }acetic acid;
tk) methyl 2-[3-({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]propanoate;
tl) 2- [3-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl}amino)phenyl]propanoic acid;
tm) 2-benzyl-3-(3- {[4-(1 H-tetrazol-5-yl)benzyl]oxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
tn) ethyl hydrogen [4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yllphenoxy}methyl)benzyl]phosphonate;
to) ethyl {3-[({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl }acetate;
tp) ethyl {3-[({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl}acetate;
tq) methyl 1- {4-[({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl }cyclopropanecarboxylate;
tr) methyl 1- {4-[({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl }cyclopropanecarboxylate;
ts) 4-({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)benzonitrile;
tt) {3-[({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyllphenyl }acetic acid;
tu) {3-[({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl }acetic acid;
tv) 1- {4-[({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]phenyl }cyclopropanecarboxylic acid;
tw) N- {3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }-N-(2,6-dimethylbenzyl)amine;
ty) 2-[3-({4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)phenyl]-2-hydroxypropanoic acid;
tz) N- {4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }-N-(2 ,6-dimethylbenzyl)amine;
uc) {4-[({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]-3,5-dimethylphenyl}acetic acid;
ud) {4-[({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl }amino)methyl]-3,5-dimethylphenyl}acetic acid;
uh) 2-benzyl-3- {3-[(2,5-difluorophenoxy)methyl]phenyl }-7-(trifluoromethyl)-2H-indazole;
vz) 2-benzyl-3-[4-(benzyloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
wa) 2-benzyl-3- {4-[(3-methoxybenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
wb) 2-benzyl-3- {4-[(2-chlorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
wc) 2-benzyl-7-(trifluoromethyl)-3-(4- {[2-(trifluoromethyl)benzyl]oxy}phenyl)-2H-indazole;
wd) 2-benzyl-3- {4-[(3-methylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
we) 2-benzyl-3- {4-[(2-methylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
wt) 2-benzyl-3- {4- [(3-chlorobenzyl)oxy3phenyl }-7-(trifluoromethyl)-2H-indazole;
wg) 2-benzyl-7-(trifluoromethyl)-3-(4- {[3-(trifluoromethyl)benzyl]oxy}phenyl)-2H-indazole;
wh) 2-benzyl-3- {4- [(3 ,5-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
wi) 2-benzyl-3- {4- [(2,6-dichlorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
wj) 2-benzyl-3- {4-[(3 ,5-dichlorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
wk) 2-benzyl-3- {3-[(3-methoxybenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
wl) 2-benzyl-3- {3-[(2-chlorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
wm) 2-benzyl-7-(trifluoromethyl)-3-(3- {[2-(trifluoromethyl)benzyl]oxy}phenyl)-2H-indazole;
wn) 2-benzyl-3- {3-[(3-methylbenzyl)oxy3phenyl }-7-(trifluoromethyl)-2H-indazole;
wo) 2-benzyl-3- {3- [(2-methylbenzyl)oxylphenyl }-7-(trifluoromethyl)-2H-indazole;
wp) 2-benzyl-7-(trifluoromethyl)-3-(3- {[3-(trifluoromethyl)benzyl]oxy}phenyl)-2H-indazole;
wq) 2-benzyl-3-(3- {[3 ,5-bis(trifluoromethyl)benzyl]oxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
wr) 2-benzyl-3- {3- [(3 ,5-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
ws) 2-benzyl-3- {3-[(2,6-dichlorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
wt) 2-benzyl-3- {3-[(3 ,5-dichlorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
wu) 1- [4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]cyclopentanecarboxylic acid;
wv) 1-[4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]cyclopropanecarboxylic acid;
ww) 2-benzyl-3- {3- [(2,6-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
wx) 2-[4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]-2-methylpropanoic acid;
wy) 2-benzyl-3- {3-[(2-fluorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
wz) 2-benzyl-3- {3-[(2-fluoro-6-nitrobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
xa) 2-benzyl-3- {3-[(2-chloro-6-fluorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
xb) 2-benzyl-3- {3-[(2,6-difluorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
xc) 2-benzyl-3- {4-[(2-fluorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
xd) 2-benzyl-3- {4-[(2-chloro-6-fluorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
xe) 2-benzyl-3- {4- [(2,6-difluorobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
xf) 2-benzyl-3-(3- {[3-(1 H-tetrazol-5-yl)benzylloxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
xg) 2-benzyl-3-(4- {[4-(1 H-tetrazol-5-yl)benzyl]oxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
xh) [4-({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)benzyl]phosphonic acid;
xi) [3-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]acetic acid;
xj) 3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenyl acetate;
xk) 2-benzyl-3- {4-[(2-fluoro-6-nitrobenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
xl) 4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl acetate;
xm) diethyl [4-({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)benzyl]phosphonate;
xn) diethyl [4-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)benzyl]phosphonate;
xo) 3-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yllphenoxy}methyl)benzonitrile;
xp) 4-({4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)benzonitrile;
xq) ethyl hydrogen [4-({4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)benzyl]phosphonate;
xr) [4-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)benzyl]phosphonic acid;
xv) 2-benzyl-3-[4-(3-methoxyphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
xw) 2-benzyl-3-[4-(2,3-difluorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
xx) 2-benzyl-3-[4-(4-chlorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
xy) 2-benzyl-3-[4-(2,3-dihydro-1 H-inden-5-yloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
xz) 2-benzyl-3-[4-(2-fluorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
ya) 2-benzyl-3- [4-(4-chloro-3 .-methylphenoxy)phenyl]-7-(trifluoromethyl)-2H-. indazole;
yb) 2-benzyl-3- [4-(2-chlorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
yc) N-(3- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)-N,N-dimethylamine;
yd) 2-benzyl-3-[4-(3-nitrophenoxy)phenylll-7-(trifluoromethyl)-2H-indazole;
ye) 2-benzyl-3- {4- [(7-methoxy-2-naphthyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
yf) 2-benzyl-3-[4-(4-fluorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
yg) 4-(4- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-y1phenoxy}benzy1)pheno1;
yh) 2-benzyl-3- [4-(5 ,6,7,8-tetrahydronaphthalen-2-yloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
yi) 7- {4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}quinoline;
yj) 2-benzyl-3-[4-(2,4-dichlorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
yk) 2-benzyl-3- [4-(2-methoxyphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
yl) 2-benzyl-3-[4-(3 ,5-difluorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
ym) 2-benzyl-3-[4-(2,3-dimethylphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
yn) 2-benzyl-3-[4-(3 ,5-dimethylphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
yr) 2-benzyl-3- {3-[(3 ,5-dimethoxybenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
ys) 2-benzyl-3- {4-[(2,6-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
yu) 2-benzyl-3-[4-(4-methylphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
yv) 2-benzyl-3-[4-(4-nitrophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
yw) 2-benzyl-3- {4-[(4′-nitro-1,1 ′-biphenyl-4-yl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
yx) 3- {4-[4-(4-acetylpiperazin-1-yl)phenoxy]phenyl }-2-benzyl-7-(trifluoromethyl)-2H-indazole;
yy) 2-benzyl-3- {3-[(2,5-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
yz) 2-benzyl-3-(3- {[2-fluoro-6-(trifluoromethyl)benzyl]oxy) phenyl)-7-(trifluoromethyl)-2H-indazole;
zk) 2-benzyl-3-[4-(2,4-difluorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
zl) 2-benzyl-3-[4-(3 ,4-dimethylphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
zm) 2-benzyl-3-[4-(2-isopropylphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
zn) 5- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-3,4-dihydronaphthalen-1 (2H)-one;
zo) 6- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}quinoline;
zp) 2-benzyl-3-[4-(2,6-dimethoxyphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
zq) 2-benzyl-3- [4-(2-methylphenoxy)phenyll-7-(trifluoromethyl)-2H4ndazole;
zr) 2- [4-({3-[2-(4-chloro-2-fluorobenzyl)-7-(trifluoromethyl)-2H-indazo[3-yl]phenoxy}methyl)phenyl]propanoic acid;
zs) 2-benzyl-3-[4-(3 ,4-dichlorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
zt) 2-benzyl-3- [4-(3 ,4-difluorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
zu) 2-benzyl-3- [4-(2,5-difluorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
zv) 8- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}quinoline;
zw) 2-benzyl-3-[4-(4-ethylphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
zx) 2-benzyl-3- [4-(2,6-difluorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
zy) 2-benzyl-3- {4-[4-(benzyloxy)phenoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
zz) 2-benzyl-3-[3-(3 ,4-dichlorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aaa) methyl 3-(4- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)propanoate;
aab) 1-(2- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)ethanone;
aac) 1-(3- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)ethanone;
aad) 2-benzyl-3-[3-(3-methylphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aae) 2-benzyl-3-[3-(2-chlorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aaf) (3- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)dimethylamine;
aag) 2-benzyl-3-[3-(3-nitrophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aah) 2-benzyl-3-[3-(2,3-dimethylphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aai) 2-benzyl-3- {3-[2-(trifluoromethoxy)phenoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aaj) 2-benzyl-3-[3-(3-methoxyphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aak) methyl 3- {3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}benzoate;
aal) 5- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-3,4-dihydronaphthalen-1 (2H)-one;
aam) 7- {3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}quinoline;
aan) 2-benzyl-3-[3-(2-isopropylphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aao) 8- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}quinoline;
aap) 2-benzyl-3- {3-[3 ,5-bis(trifluoromethyl)phenoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aaq) 2-benzyl-3- {3- [(7-methyl-i -naphthyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aar) 4- {3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}acridine;
aas) 2-benzyl-3- {3-[2-(benzyloxy)phenoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aat) (2- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)(phenyl)methanone;
aau) 2-benzyl-3-[3-(biphenyl-2-yloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aav) 2-(2- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl7jphenoxy}phenyl)-1,3-benzothiazole;
aaw) 2-benzyl-3- {3-[2-(1 H-pyrrol-1-yl)phenoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
aax) 2-benzyl-3-[3-(3 ,4-difluorophenoxy)phenyl].-7-(trifluoromethyl)-2H-indazole;
aay) 2-benzyl-3-[3-(2,3-difluorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aaz) 2-benzyl-3-[3-(2,5-difluorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aba) 2-benzyl-3- {3- [(7-methoxy-2-naphthyl)oxylphenyl }-7-(trifluoromethyl)-2H-indazole;
abb) 1-(2- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-4-methoxyphenyl)ethanone;
abc) 6- {3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}quinoline;
abd) 2-benzyl-3-[3-(3 ,5-dimethylphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
abe) 2-benzyl-3-[3-(2-methoxyphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
abf) 2-benzyl-3-[3-(1-naphthyloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
abg) 2-benzyl-3-(3- {2-[(1 E)-prop-1-en-i -yl]phenoxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
abh) 2-benzyl-3-[3-(3,5-difluorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
abi) 2-benzyl-3-[3-(3,5-dichlorophenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
abj) 2-benzyl-3-[3-(3,5-dimethoxyphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
acj) 2-benzyl-3-[4-(bemzyloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
ack) 1- [4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]cyclopentanecarboxylic acid;
acl) 2- [4-({3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)phenyl]-2-methylpropanoic acid;
acs) 2-benzyl-3-(4- {[2-fluoro-6-(trifluoromethyl)benzyl]oxy}phenyl)-7-(trifluoromethyl)-2H-indazole;
act) [4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)-3 ,5 -dimethylphenyl]acetic acid;
acu) [4-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)-3 ,5 -dimethylphenyl]acetic acid;
acx) 4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)-3 ,5 -dibromobenzoic acid;
acy) 4-({4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl}-3 ,5-dibromobenzoic acid;
acz) 4-({3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}methyl)-3 ,5 -dimethylbenzoic acid;
ada) 2-benzyl-3- {4-[(2,5-dimethylbenzyl)oxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
ade) {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}(3-methylphenyl)acetic acid;
adf) {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}(3-methylphenyl)acetic acid;
adg) 2-benzyl-3- [4-(2-naphthylmethoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
adh) 2-benzyl-3-114-(1-naphthylmethoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
adi) 2-benzyl-3- {4-[(3-methyl-2-naphthyl)methoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
adj) 2-benzyl-3 43-(2-naphthylmethoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
adk) 2-benzyl-3-[3-(1-naphthylmethoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
adl) 2-benzyl-3- {3-[(3-methyl-2-naphthyl)methoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
adm) 2-benzyl-3- {4-[(2-methyl-1-naphthyl)methoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
adn) 3- [4-(9-anthrylmethoxy)phenyl]-2-benzyl-7-(trifluoromethyl)-2H-indazole;
ado) 2-benzyl-3- {3-[(2-methyl-i -naphthyl)methoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
adp) 3- [3-(9-anthrylmethoxy)phenyl]-2-benzyl-7-(trifluoromethyl)-2H-indazole;
agj) 2-benzyl-3-(3-phenoxyphenyl)-7-(trifluoromethyl)-2H-indazole;
agk) 2-benzyl-3-[3-(4-methoxyphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
agl) 3- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}benzaldehyde;
agm) 2-benzyl-3- {3-[3-(1,3-dioxolan-2-ylmethyl)phenoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
agn) (3- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)acetic acid;
ago) (3- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)acetic acid;
agp) 2-benzyl-3- {4- [3-(1 ,3-dioxolan-2-ylmethyl)phenoxy]phenyl)-7-(trifluoromethyl)-2H-indazole;
agq) 2-benzyl-3- [4-(3 ,5-dimethylphenoxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
agr) methyl 2-(4- {3- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)-2-methylpropanoate;
ags) methyl 3- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}benzoate;
agt) (3- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)methanol;
agu) 3- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-N-methoxy-N-methylbenzamide;
agv) 3- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-N,N-dimethylbenzamide;
agw) 3- {4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yllphenoxy}-N-methylbenzamide;
agx) 3- {4- [2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}benzamide;
ahj) 2-benzyl-3- {4-[2-(trifluoromethoxy)phenoxy]phenyl }-7-(trifluoromethyl)-2H-indazole;
ahk) 2-benzyl-3- [4-(1-naphthyloxy)phenyl]-7-(trifluoromethyl)-2H-indazole;
aho) 2- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}benzaldehyde;
ahu) 2-(3- {4-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)propan-2-ol;
ahz) 3- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}-N,N-dimethylbenzamide; and
aic) 2-(3- {3-[2-benzyl-7-(trifluoromethyl)-2H-indazol-3-yl]phenoxy}phenyl)-2-methylpropanoic acid; or a pharmaceutically acceptable salt thereof.
35. The compound of claim 1 , wherein the compound is 2-(2-chloro-4-fluoro-benzyl)-3-(4-fluoro-phenyl)-7-trifluoromethyl-2H-indazole or a pharmaceutically acceptable salt thereof.
36. The compound of claim 1 , wherein the compound is 2-(2-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole or a pharmaceutically acceptable salt thereof.
37. The compound of claim 1 , wherein the compound is 2-(2-chlorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole or a pharmaceutically acceptable salt thereof.
38. The compound of claim 1 , wherein the compound is 2-(3,4-difluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole or a pharmaceutically acceptable salt thereof.
39. The compound of claim 1 , wherein the compound is 2-(2,4-difluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole or a pharmaceutically acceptable salt thereof.
40. The compound of claim 1 , wherein the compound is 2-(4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole or a pharmaceutically acceptable salt thereof.
41. The compound of claim 1 , wherein the compound is 2-(4-chlorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole or a pharmaceutically acceptable salt thereof.
42. The compound of claim 1 , wherein the compound is 2-(4-chloro-2-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole or a pharmaceutically acceptable salt thereof.
43. The compound of claim 1 , wherein the compound is 2-(2-chloro-6-fluorobenzyl)-3 .-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole or a pharmaceutically acceptable salt thereof.