Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
In accordance with the present invention there is provided a method for the treatment of peripheral arterial diseases in a host comprising administering a therapeutically effective amount of compounds having the formulas (I) through (III) or analogues thereof.
1 . A method for the treatment of peripheral arterial disease comprising the step of administering to a subject in need thereof a therapeutically effective amount of a compound of formula
an equilibrating form thereof, a pharmaceutically acceptable salt of the compound or of the equilibrating form thereof,
wherein,
R1 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, or C 6-10 aryl;
R2 is
R3 is OH, Halogen, SH, O—C 1-6 alkyl or an hydroxymimetic group; and
X and Y are independently H or halogen.
2 . The method of claim 1 , wherein the compound has the formula
3 . The method of claim 1 , wherein R2 is
4 . The method of claim 1 , wherein R1 is H or C 1-6 alkyl.
5 . The method of claim 1 , wherein R1 is H.
6 . The method of claim 1 , wherein X is H or halogen.
7 . The method of claim 1 , wherein Y is H or Cl.
8 . The method of claim 1 , wherein X is Cl.
9 . The method of claim 1 , wherein Y is Cl.
10 . The method of claim 1 , wherein the compound is
11 . A method for inhibiting phosphodiesterase comprising the step of administering to a subject in need thereof a therapeutically effective amount of a compound of formula
an equilibrating form thereof, a pharmaceutically acceptable salt of the compound or of the equilibrating form thereof,
wherein,
R1 is H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, or C 6-10 aryl;
R2 is
R3 is OH, Halogen, SH, O—C 1-6 alkyl or an hydroxymimetic group; and
X and Y are independently H or halogen.
12 . The method of claim 11 , wherein the compound has the formula
13 . The method of claim 11 , wherein R2 is
14 . The method of claim 11 , wherein R1 is H or C 1-6 alkyl.
15 . The method of claim 11 , wherein R1 is H.
16 . The method of claim 11 , wherein X is H or halogen.
17 . The method of claim 11 , wherein Y is H or Cl.
18 . The method of claim 11 , wherein X is Cl.
19 . The method of claim 11 , wherein Y is Cl.
20 . The method of claim 11 , wherein the compound is