Methods for treating diseases or conditions using dihydropteridinone compounds
View Patent ↗Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R 1 -R 5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
1. A Compound selected from the group consisting of the compounds of formula (I) as shown in the following Table
Config.
Example
R 1
R 2
R 1 or R 2
27
H
R
44
H
R
55
H
R
58
H
R
102
H
R
103
H
R
105
H
R
110
H
R
115
H
R
133
H
R
134
H
R
234
H
R
240
H
R
Example
R 3
R 4
L n —R m 5
27
44
H
55
58
102
103
105
110
115
133
134
234
240
or a pharmacologically acceptable acid addition salt thereof,
wherein the abbreviations X1, X2, X3, X4 and X5 used in the Table in each case denote a link to a position in the general formula shown under the Table instead of the corresponding groups R1, R2, R3, R4 and L-R5.
2. The compound according to claim 1 wherein the compound is
Ex-
Config.
am-
R 1
ple
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
27
H
R
or a pharmacologically acceptable acid addition salt thereof.
3. The compound according to claim 1 wherein the compound is
Config. R 1
Example
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
44
H
R
H
or a pharmacologically acceptable acid addition salt thereof.
4. The compound according to claim 1 wherein the compound is
Ex-
Config.
am-
R 1
ple
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
55
H
R
or a pharmacologically acceptable acid addition salt thereof.
5. The compound according to claim 1 wherein the compound is
Ex-
Config.
am-
R 1
ple
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
58
H
R
or a pharmacologically acceptable acid addition salt thereof.
6. The compound according to claim 1 wherein the compound is
Config. R 1
Example
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
102
H
R
or a pharmacologically acceptable acid addition salt thereof.
7. The compound according to claim 1 wherein the compound is
Ex-
Config.
am-
R 1
ample
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
103
H
R
or a pharmacologically acceptable acid addition salt thereof.
8. The compound according to claim 1 wherein the compound is
Ex-
Config. R 1
ample
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
105
H
R
or a pharmacologically acceptable acid addition salt thereof.
9. The compound according to claim 1 wherein the compound is
Ex-
Config.
am-
R 1
ample
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
110
H
R
or a pharmacologically acceptable acid addition salt thereof.
10. The compound according to claim 1 wherein the compound is
Config. R 1
Example
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
115
H
R
or a pharmacologically acceptable acid addition salt thereof.
11. The compound according to claim 1 wherein the compound is
Ex-
Config.
am-
R 1
ple
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
133
H
R
or a pharmacologically acceptable acid addition salt thereof.
12. The compound according to claim 1 wherein the compound is
Config. R 1
Example
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
134
H
R
or a pharmacologically acceptable acid addition salt thereof.
13. The compound according to claim 1 wherein the compound is
Config. R 1
Example
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
234
H
R
or a pharmacologically acceptable acid addition salt thereof.
14. The compound according to claim 1 wherein the compound is
Ex-
Config.
am-
R 1
ple
R 1
R 2
or R 2
R 3
R 4
L n —R 5 m
240
H
R
or a pharmacologically acceptable acid addition salt thereof.