Hexafluoroisopropanol substituted ether derivatives

1. A compound of the formula (I):

wherein:

R 1 is hydrogen, lower-alkyl, or halogen;

one of R 2 and R 3 is hydrogen, lower-alkyl, or halogen; and

the other of R 2 and R 3 is —O—CHR 4 —(CH 2 ) m —(CHR 5 ) n —R 6 ;

R 4 is hydrogen, lower-alkyl, aryl, aryl-lower-alkyl, heteroaryl, or heteroaryl-lower-alkyl;

R 5 is hydrogen or aryl;

R 6 is phenyl or aryl-lower-alkyl, which phenyl or aryl-lower-alkyl is optionally substituted with 1 to 3 substituents selected from the group consisting of amino, halogen, lower-alkyl, fluoro-lower-alkyl, hydroxy-lower-alkyl, R 8 —O—C(O)—, R 9 R 10 NC(O)—, R 11 —O—C(O)-lower-alkyl, R 12 R 13 NC(O)-lower-alkyl, lower-alkoxy and aryl-lower-alkoxy;

or R 6 is 5- to 6-membered monocyclic heteroaryl which is optionally substituted with 1 to 3 substituents selected from the group consisting of lower-alkyl, fluoro-lower-alkyl, halogen and aryl, which aryl is optionally substituted with 1 to 3 substituents selected from the group consisting of amino, halogen, lower-alkyl, fluoro-lower-alkyl, hydroxy-lower-alkyl, R 8 —O—C(O)—, R 9 R 10 NC(O)—, R 11 —O—C(O)-lower-alkyl, R 12 R 13 NC(O)-lower-alkyl, lower-alkoxy and aryl-lower-alkoxy;

or R 6 is 9-membered bicyclic heteroaryl which is optionally substituted with 1 to 3 substituents selected from the group consisting of lower-alkyl, fluoro-lower-alkyl, halogen and aryl, which aryl is optionally substituted with 1 to 3 substituents selected from the group consisting of, amino, halogen, lower-alkyl, fluoro-lower-alkyl, hydroxy-lower-alkyl, R 8 —O—C(O)—, R 9 R 10 NC(O)—, R 11 —O—C(O)-lower-alkyl, R 12 R 13 NC(O)-lower-alkyl, lower-alkoxy and aryl-lower-alkoxy;

or R 6 is heteroaryl-lower-alkyl which is optionally substituted with 1 to 3 substituents selected from the group consisting of lower-alkyl, fluoro-lower-alkyl, halogen and aryl, which aryl is optionally substituted with 1 to 3 substituents selected from the group consisting of amino, halogen, lower-alkyl, fluoro-lower-alkyl, hydroxy-lower-alkyl, R 8 —O—C(O)—, R 9 R 10 NC(O)—, R 11 —O—C(O)-lower-alkyl R 12 R 13 NC(O)-lower-alkyl, lower-alkoxy and aryl-lower-alkoxy;

or R 6 is —O—R 7 or lower-alkyl-OR 7 ;

R 7 is aryl which is optionally substituted with 1 to 3 substituents selected from the group consisting of amino, halogen, lower-alkyl, fluoro-lower-alkyl, hydroxy-lower-alkyl, R 8 —O—C(O)—, R 9 R 10 NC(O)—, R 11 —O—C(O)-lower-alkyl, R 12 R 13 NC(O)-lower-alkyl, lower-alkoxy and aryl-lower-alkoxy;

or R 7 is heteroaryl which is optionally substituted with 1 to 3 substituents selected from the group consisting of lower-alkyl, fluoro-lower-alkyl, halogen, amino, hydroxy-lower-alkyl, R 8 —O—C(O)—, R 9 R 10 NC(O)—, R 11 —O—C(O)-lower-alkyl, R 12 R 13 NC(O)-lower-alkyl, lower-alkoxy, aryl-lower-alkoxy and aryl, which aryl is optionally substituted with 1 to 3 substituents selected from the group consisting of lower-alkyl and halogen;

R 8 , R 9 , R 10 , R 11 , R 12 and R 13 independently from each other are hydrogen or lower-alkyl;

m is 0 to 3;

n is 0 or 1;

and pharmaceutically acceptable salts and esters thereof.

2. The compound according to claim 1 , wherein R 1 is hydrogen, chlorine or methyl.

3. The compound according to claim 1 , wherein one of R 2 and R 3 is hydrogen or lower-alkyl, and the other of R 2 and R 3 is —O—CHR 4 —(CH 2 ) m —(CHR 5 ) n —R 6 , wherein R 4 , R 5 , R 6 , m and n are as defined in claim 1 .

4. The compound according to claim 1 , wherein R 2 is —O—CHR 4 —(CH 2 ) m —(CHR 5 ) n —R 6 , and R 3 is hydrogen, wherein R 4 , R 5 , R 6 , m and n are as defined in claim 1 .

5. The compound according to claim 1 , wherein R 4 is hydrogen, lower-alkyl, aryl, or aryl-lower-alkyl.

6. The compound according to claim 1 , wherein R 4 is hydrogen, lower-alkyl, or aryl-lower-alkyl.

7. The compound according to claim 1 , wherein R 4 is hydrogen, methyl or benzyl.

8. The compound according to claim 1 , wherein n is 1 and R 5 is aryl.

9. The compound according to claim 1 , wherein n is 1 and R 5 is phenyl.

10. The compound according to claim 1 , wherein R 6 is phenyl which is optionally substituted with R 8 —O—C(O)—, or R 6 is 5- to 6-membered monocyclic heteroaryl which is optionally substituted with 1 to 3 substituents selected from the group consisting of lower-alkyl and aryl, which aryl is optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, lower-alkyl, fluoro-lower-alkyl, hydroxy-lower-alkyl, R 8 —O—C(O)— and R 9 R 10 NC(O)—, wherein R 8 , R 9 and R 10 are as defined in claim 1 .

11. The compound according to claim 1 , wherein R 6 is phenyl, or R 6 is oxazolyl, which oxazolyl is substituted with lower-alkyl and phenyl, which phenyl is substituted with halogen, fluoro-lower-alkyl or hydroxy-lower-alkyl.

12. The compound according to claim 1 , wherein R 6 is phenyl, 2-(3-chloro-phenyl)-5- methyl-oxazol-4-yl, 5-methyl-2-(3-trifluoromethyl-phenyl)-oxazol-4-yl, or 2-(3-hydroxymethyl-phenyl)-5-methyl-oxazol-4-yl.

13. The compound according to claim 1 , wherein R 6 is —O—R 7 , wherein R 7 is phenyl which is substituted with 1 substituent selected from the group consisting of hydroxy-lower-alkyl, R 11 —O—C(O)-lower-alkyl and R 12 R 13 NC(O)-lower-alkyl, or R 7 is heteroaryl selected from the group consisting of benzo[d] isothiazolyl and benzo[d]isoxazolyl, which heteroaryl is optionally substituted with 1 to 2 substituents selected from the group consisting of lower-alkyl, fluoro-lower-alkyl and phenyl, which phenyl is optionally substituted with halogen, wherein R 11 , R 12 and R 13 are as defined in claim 1 .

14. The compound according to claim 13 , wherein R 7 is phenyl substituted with lower-alkoxy-carbonyl or lower-alkoxy-carbonyl-lower-alkyl.

15. The compound according to claim 14 , wherein R 7 is 3-methoxycarbonylmethyl-phenyl, 4-methoxycarbonylmethyl-phenyl, or 4-methoxycarbonyl-phenyl.

16. The compound according to claim 1 , wherein m is 0 to 2.

17. The compound according to claim 1 , wherein m is 0 or 1.

18. The compound according to claim 1 , wherein n is 0.

19. The compound according to claim 1 , selected from the group consisting of

2-(4-{3-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-propoxy}-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol,

3-(3-{3-[3-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-propionic acid ethyl ester,

rac (4-{1-Phenyl-2-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid methyl ester,

rac (4-{1-Phenyl-2-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid,

rac 4-{1-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-benzoic acid methyl ester,

4-{2-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-benzoic acid methyl ester,

2-(4-Benzyloxy-3-chloro-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-(4-Benzyloxy-3-methyl-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-(3-Benzyloxy-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-(4-Benzyloxy-3,5-dimethyl-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-(4-Benzyloxy-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol,

(4-{3-[2-Methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid methyl ester,

4-{3-[2-Methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-benzoic acid methyl ester,

3-(4-{3-[2-Chloro-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-propionic acid methyl ester,

(4-{3-[2-Chloro-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid methyl ester,

4-{3-[2-Chloro-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-benzoic acid methyl ester,

(4-{3-[2,6-Dimethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid methyl ester,

4-{3-[2,6-Dimethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-benzoic acid methyl ester,

4-{3-[2-Methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-benzoic acid,

(4-{3-[2-Methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid,

(4-{3-[2,6-Dimethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid,

4-{3-[2,6-Dimethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-benzoic acid,

4-{2-[2,6-Dimethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-benzoic acid methyl ester,

3-(4-{(S)-2-[2-Methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-3-phenyl-propoxy}-phenyl)-propionic acid methyl ester,

(4-{(S)-2-[2-Methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-3-phenyl-propoxy}-phenyl)-acetic acid methyl ester,

4-{(S)-2-[2-Methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-3-phenyl-propoxy}-benzoic acid methyl ester,

(4-{(S)-3-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid methyl ester,

4-{(S)-3-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-benzoic acid methyl ester,

(4-{(S)-2-[2-Methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-3-phenyl-propoxy}-phenyl)-acetic acid,

4-{(S)-2-[2-Methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-3-phenyl-propoxy}-benzoic acid,

(4-{(S)-3-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid,

4-{(S)-3-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-benzoic acid,

rac 1,1,1,3,3,3-Hexafluoro-2-{4-[2-(4-hydroxymethyl-phenoxy)-1-phenyl-ethoxy]-phenyl}-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-(3-methyl-4-phenethyloxy-phenyl)-propan-2-ol,

rac 1,1,1,3,3,3-Hexafluoro-2-[3-methyl-4-(1-phenyl-ethoxy)-phenyl]-propan-2-ol,

2-{4-[2-(3-Chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-[4-(3,5-Dimethyl-isoxazol-4-ylmethoxy)-phenyl]-1,1,1,3,3, 3-hexafluoro-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-[4-(5-methyl-isoxazol-3-ylmethoxy)-phenyl]-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-[4-(5-methyl-2-phenyl-2#H !-[1,2,3]triazol-4-ylmethoxy)-phenyl]-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-[4-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-phenyl]-propan-2-ol,

3-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxymethyl]-benzoic acid methyl ester,

4-{(S)-2-[2-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-3-phenyl-propoxy}-benzoic acid,

(4-{(S)-3-phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid,

3-(4-{(R)-3-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-propionic acid methyl ester,

(4-{(R)-3-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid methyl ester,

4-{(R)-3-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-benzoic acid methyl ester,

3-(4-{(R)-3-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-propionic acid,

(4-{(R)-3-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid,

4-{(R)-3-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-benzoic acid,

2-{4-[2-(3-Chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-3-methyl-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-{3-Chloro-4-[2-(3-chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-(4-phenethyloxy-phenyl)-propan-2-ol,

2-(3,5-Dimethyl-4-phenethyloxy-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-(3-Chloro-4-phenethyloxy-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol,

rac 1,1,1,3,3,3-Hexafluoro-2-[4-(1-phenyl-ethoxy)-phenyl]-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-[3-methyl-4-(5-methyl-2-m-tolyl-oxazol-4-ylmethoxy)-phenyl]-propan-2-ol,

2-{4-[2-(2-Chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-3-methyl-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-[3-methyl-4-(5-methyl-2-o-tolyl-oxazol-4-ylmethoxy)-phenyl]-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-{3-methyl-4-[5-methyl-2-(3-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-{4-[2-(4-fluoro-3-methyl-phenyl)-5-methyl-oxazol-4-ylmethoxy]-3-methyl-phenyl}-propan-2-ol,

2-{3-Chloro-4-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-[3-Chloro-4-(5-methyl-2-m-tolyl-oxazol-4-ylmethoxy)-phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-{3-Chloro-4-[2-(2-chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-[3-Chloro-4-(5-methyl-2-o-tolyl-oxazol-4-ylmethoxy)-phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-{3-Chloro-4-[5-methyl-2-(3-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-{3-Chloro-4-[2-(4-fluoro-3-methyl-phenyl)-5-methyl-oxazol-4-ylmethoxy]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-{3-[2-(3-Chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-[3-(5-methyl-2-o-tolyl-oxazol-4-ylmethoxy)-phenyl]-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-{3-[5-methyl-2-(3-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-propan-2-ol,

2-{3-[2-(2-Chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-[3-(5-methyl-2-m-tolyl-oxazol-4-ylmethoxy)-phenyl]-propan-2-ol,

3-{4-[2-Chloro-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxymethyl]-5-methyl-oxazol-2-yl}-benzoic acid methyl ester,

2-{3-Chloro-4-[2-(3-hydroxymethyl-phenyl)-5-methyl-oxazol-4-ylmethoxy]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

4-{5-Methyl-4-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxymethyl]-oxazol-2-yl}-benzoic acid methyl ester,

4-{5-Methyl-4-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxymethyl]-oxazol-2-yl}-benzoic acid,

N,N-Dimethyl-4-{5-methyl-4-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxymethyl]-oxazol-2-yl}-benzamide,

(3-{2-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid methyl ester,

(4-{2-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid methyl ester,

(3-{2-[3-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid methyl ester,

(3-{2-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid,

(4-{2-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid,

rac (3-{1-Phenyl-2-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid methyl ester,

rac (3-{1-Phenyl-2-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid,

rac N,N-Dimethyl-2-(3-{1-phenyl-2-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetamide,

2-(4-{2-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-ethoxy}-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-{4-[3-(7-propyl-3-trifluoromethyl-benzo[d]isoxazol-6-yloxy)-propoxy]-phenyl}-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-{3-[3-(7-propyl-3-trifluoromethyl-benzo[d]isoxazol-6-yloxy)-propoxy]-phenyl}-propan-2-ol,

(4-{3-[3-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid methyl ester,

(3-{3-[3-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid methyl ester,

3-(4-{3-[3-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-propionic acid methyl ester, and

3-(4-{3-[3-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-propionic acid,

and pharmaceutically acceptable salts and esters thereof.

20. The compound according to claim 1 , selected from the group consisting of

(3-{2-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-phenyl)-acetic acid methyl ester,

rac 4-{1-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-ethoxy}-benzoic acid methyl ester,

2-(4-Benzyloxy-3-chloro-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol,

(4-{(S)-3-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid methyl ester, 1,1,1,3,3,3-Hexafluoro-2-(3-methyl-4-phenethyloxy-phenyl)-propan-2-ol,

rac 1,1,1,3,3,3-Hexafluoro-2-[3-methyl-4-(1-phenyl-ethoxy)-phenyl]-propan-2-ol,

2-{4-[2-(3-Chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

(4-{(R)-3-Phenyl-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-acetic acid methyl ester,

2-{3-Chloro-4-[2-(3-chloro-phenyl)-5-methyl-oxazol-4-ylmethoxy]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

2-(3-Chloro-4-phenethyloxy-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol,

1,1,1,3,3,3-Hexafluoro-2-{3-methyl-4-[5-methyl-2-(3-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-propan-2-ol,

2-{3-Chloro-4-[5-methyl-2-(3-trifluoromethyl-phenyl)-oxazol-4-yl methoxy]-phenyl}- 1,1,1,3,3,3-hexafluoro-propan-2-ol, and

2-{3-Chloro-4-[2-(3-hydroxymethyl-phenyl)-5-methyl-oxazol-4-yl methoxy]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol,

and pharmaceutically acceptable salts and esters thereof.

21. A process for the manufacture of a compound according to claim 1 , comprising the steps of:

a) reacting a compound of formula (II)

 with a compound HO—CHR 4 —(CH 2 ) m —(CHR 5 ) n —R 6 ,

wherein R 1 , R 4 , R 5 , R 6 , m and n are as defined in any of claims 1 - 20 , one of R 2′ and R 3′ is OH and the other of R 2′ and R 3′ is hydrogen, lower-alkyl, or halogen, and A is hydrogen or a protecting group, or

b) reacting a compound of formula (II)

 with a compound LG-CHR 4 —(CH2) m —(CHR 5 ) n —R 6

wherein R 1 , R 4 , R 5 , R 6 , m and n are as defined in any of claims 1 - 20 , one of R 2′ and R 3′ is OH and the other of R 2′ and R 3′ is hydrogen, lower-alkyl, or halogen, LG is a leaving group and A is hydrogen or a protecting group.

22. A pharmaceutical composition, comprising a compound according to claim 1 and a pharmaceutically acceptable carrier and/or adjuvant.