Method of treating staphylococcus aureus infection
The present invention provides a method of preventing or treating bacteremia caused by Staphylococcus aureus, comprising administering a monoclonal or polyclonal antibody composition comprising antibodies specific for one or more S. aureus antigens. In one specific embodiment, the composition is a hyperimmune specific IGIV composition. In another specific embodiment, the composition comprise antibodies to a capsular polysaccharide S. aureus antigen, such as the Type 5 and/or Type 8 antigens. In another embodiment, the composition comprises monoclonal antibodies to a capsular polysaccharide S. aureus antigen. This method provides an effective tool for preventing or treating S. aureus bacteremia, and can be used alone or in combination with other therapies.
1 . A method of treating S. aureus bacteremia comprising:
administering to a patient suffering from S. aureus bacteremia an effective amount of an antibody composition comprising antibodies specific for one or more antigens of S. aureus.
2 . The method of claim 1 , wherein the antibody composition is an IGIV composition.
3 . The method of claim 2 , wherein the antibody composition is a hyperimmune specific IGIV composition.
4 . The method of claim 1 , wherein the antibody composition comprises recombinant antibodies.
5 . The method of claim 1 , wherein the antibody composition comprises monoclonal antibodies.
6 . The method of claim 1 , wherein the antibody composition comprises antibodies specific to one or more capsular polysaccharide antigens of Staphylococcus aureus.
7 . The method of claim 6 , wherein the antibody composition comprises antibodies specific to one or more antigens selected from the group consisting of the Type 5 antigen, the Type 8 antigen, and the 336 antigen.
8 . The method of claim 7 , wherein the antibody composition comprises antibodies specific to the Type 5 antigen and the Type 8 antigen.
9 . The method of claim 7 wherein the antibody composition comprises antibodies specific to the 336 antigen.
10 . The method of claim 7 , wherein the antibody composition comprises antibodies specific to the Type 5 antigen, the Type 8 antigen, and the 336 antigen.
11 . The method of claim 1 , wherein the bacteremia is characterized by a persistent fever.
12 . The method of claim 1 , wherein the bacteremia is caused by antibiotic resistant Staphylococcus.
13 . The method of claim 12 , wherein the Staphylococcus is resistant to methicillin.
14 . The method of claim 12 , wherein the Staphylococcus is resistant to vancomycin.
15 . The method of claim 1 , wherein the patient is immunocompromised.
16 . The method of claim 1 , wherein the patient is allergic to at least one antibiotic used to treat Staphylococcus.
17 . The method of claim 1 , further comprising an additional therapy against Staphylococcus infection.
18 . The method of claim 17 , wherein the additional therapy comprises the administration of one or more antibiotics.
19 . The method of claim 18 , wherein the additional therapy comprises the administration of one or antimicrobial agents.
20 . The method of claim 19 , wherein the additional therapy comprises the administration of lysostaphin.
21 . The method of claim 1 , wherein the antibody composition comprises an immunostimulatory compound.
22 . The method of claim 22 , wherein the immunostimulatory compound is selected from the group consisting of B-glucans and GM-CSF.
23 . The method of claim 1 , wherein the antibodies comprise antibodies specific for the native form of one or more antigens of S. aureus.
24 . The method of claim 1 , wherein the antibodies comprise antibodies specific for a modified form of one or more antigens of S. aureus.
25 . The method of claim 24 , wherein the antibodies comprise antibodies specific for a de-O-acetylated form of an S. aureus Type 5 antigen or a de-O-acetylated form of an S. aureus Type 8 antigen.
26 . A method of preventing S. aureus bacteremia comprising:
administering to a patient at risk for developing S. aureus bacteremia an effective amount of an antibody composition comprising antibodies specific for one or more antigens of S. aureus.