IP Library › Granted Patent US 7,482,123
Granted Patent B2
US 7,482,123 · App. 11/267,461 · Granted Jan 27, 2009

Biomarkers for prostate cancer metastasis

Assignee: The Regents of the University of California
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Quick Facts
Patent No.
US 7,482,123
App. No.
11/267,461
Granted
Jan 27, 2009
Kind
B2
Abstract

The present invention provides genomic markers for determining the predisposition of prostate cancer to become metastasized.

Claims (3)

1. A method for determining the risk of metastasis of prostate cancer in a human who has or had prostate cancer, the method comprising, detecting in a prostate tumor sample from the human the number of copies per cell of each of the genomic regions: 2qtel, 3q26.2, 3q26.32, 5pl5.1, 7p22.3, 7q11.23, 7q11.22, 7q22.1, 7q31.31, 9q34.11, 11p15.5, 17q21.33, 17q25.3, 22q13.1, 4p13, 5q13.1, 5q14.3, 5q21.1, 5q21.2, 5q21.3, 5q23.1, 6q14.1, 6q21, 8p22, 8p21.2, 8p12, 10q23.31, 13q14.11, 13q14.13, 13q14.2, 13q14 and 16q23.1, wherein an increase in the number of copies per cell of each of the genomic regions: 2qtel, 3q26.2, 3q26.32, 5pl5.1, 7p22.3, 7q11.23, 7q11.22, 7q22.1, 7q31.31, 9q34.11, 11p15.5, 17q21.33, 17q25.3 and 22q13.1 and/or a decrease in the number of copies per cell of each of the genomic regions: 4p13, 5q13.1, 5q14.3, 5q21.1, 5q21.2, 5q21.3, 5q23.1, 6q14.1, 6q21, 8p22, 8p21.2, 8p12, 10q23.31, 13q14.11, 13q14.13, 13q14.2, 13q14 and 16q23.1, compared to the number of copies per cell in non-cancer cells, indicates an increased risk of prostate cancer metastasis.

2. The method of claim 1 , wherein said detecting comprises hybridizing genomic DNA present in the prostate tumor sample with at least one BAC selected from the group consisting of CTB-172I13, RP11-1146E5, RP11-114M1, RP1-97B16, RP11-88L18, RP11-23D23, CTC-329F6, RP1-117G9, RP11-96016, RP11-213E22, CTD-2041 G23, RP11-1704, RP4-693L23, RP5-1071114, RP11-46E14, RMC22P003, RP11-25305, RP11-267K19, RP11-135F5, RP11-203J7, RP11-115L24, CTD-2079J2, RP11-73N22, RP11-217L13, RP11-28L24, RP11-47E20, RP11-182G2, RP11-76B12, RP11-232J22, CTD-2015D3, RP11-5713, RP11-129G17, RP11-14A4, CTD-2202J2, RP11-17I11, RP11-217H23, CTD-2173J2, RP1-269F22, and RP11-12H11.

3. The method of claim 1 , wherein said genomic regions comprise the genes EVI1, PIK3CA, EIF3S9, ELN, AUTS2, VGF, Serpinel, PLOD3, AP1S1, CORTBP2, p57 (KIP2), NGFR, CBX4, CBX8, PDGFB, FER, TUBE1, LAMA4, BVES, POPDC3, TUSC3, DOCK5, BNIP3L, ADRA1, NRG1, LHFP, GTF2F2, RB 1 and CHC1L.

Assignments (4)
CONFIRMATORY LICENSE Recorded Jul 16, 2010
From: UNIVERSITY OF CALIFORNIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 024700/0338 →
EXECUTIVE ORDER 9424, CONFIRMATORY LICENSE Recorded Dec 18, 2008
From: UNIVERSITY OF CALIFORNIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 022003/0916 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 11, 2006
From: PARIS, PAMELA L.; COLLINS, COLIN C.
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 018095/0225 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 31, 2006
From: PARIS, PAMELA L.; COLLINS, COLIN C.
To: REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 017224/0322 →
Continuity (2)
Provisional Application 6062539900 · Nov 5, 2004
Related Publication 20060110759A1 · May 25, 2006