Peptides and methods for the control of obesity
View Patent ↗The subject invention provides novel peptides for use in treating mammals to control appetite and obesity. Disclosed is a peptide derivative having the formula: X 1 -Z-Q-arg-trp-NH 2 wherein: X 1 is an acyl group, Z is amino-2-naphthyl-carboxylic acid or histidine, Q is (D)phenylalanine or p-iodo-(D)phenylalanine, or a pharmacologically acceptable salt, complex or derivative thereof, the peptide derivative having melanocortin-4 receptor agonist activity.
1. A peptide derivative having the formula: X 1 -Z-Q-arg-trp-NH 2 wherein: X 1 is acetyl, Z is amino-2-naphthyl-carboxylic acid or histidine, Q is p-iodo-(D)phenylalanine; or a pharmacologically acceptable salt or complex thereof, said peptide derivative having melanocortin-4 receptor agonist activity.
2. The peptide derivative according to claim 1 wherein Z is histidine.
3. A composition for the treatment of obesity, hypertension, type II diabetes, or the control of appetite in a mammal comprising an effective amount of a peptide derivative of claim 1 in combination with a carrier therefore.
4. A method for the treatment of obesity, hypertension, type II diabetes, or control of appetite comprising administering to a mammal in need thereof an effective amount of a peptide derivative according to claim 1 .
5. A peptide derivative having the formula:
X 1 -Z-Q-arg-trp-NH 2
wherein: X 1 is acetyl, Z is amino-2-naphthyl-carboxylic acid, Q is (D)phenylalanine or p-iodo-(D)phenylalanine; or a pharmacologically acceptable salt or complex thereof, said peptide derivative having melanocortin-4 receptor agonist activity.
6. The peptide derivative according to claim 5 wherein Q is (D)phenylalanine.
7. The peptide derivative according to claim 5 wherein Q is p-iodo-(D)phenylalanine.
8. A composition for the treatment of obesity, hypertension, type II diabetes, or the control of appetite in a mammal comprising an effective amount of a peptide derivative of claim 5 in combination with a carrier therefore.
9. A method for the treatment of obesity, hypertension, type II diabetes, or control of appetite comprising administering to a mammal in need thereof an effective amount of a peptide derivative according to claim 5 .