IMPROVED COX-2 INHIBITORY COMPOSITIONS AND THERAPEUTIC REGIMEN
This invention provides improved COX-2 inhibitory compositions comprising a combination of a selective inhibitor of COX-2 and a prostacyclin promoter, especially an antioxidant of the type known as food extracts. The invention also provides a regimen treating a disease that is responsive to inhibition of cyclooxygenase-2, comprising administering to a patient suffering from such a disease the combination of the invention comprising a selective inhibitor of COX-2 and a prostacyclin promoter in amounts and at intervals effective to therapeutically inhibit COX-2 while maintaining a therapeutically significant level of prostacyclin production.
1 . Improved COX-2 inhibitory compositions comprising a combination of a selective inhibitor of COX-2 and a prostacyclin promoter.
2 . COX-2 inhibitory compositions according to claim 1 , wherein the prostacyclin promoter comprises an antioxidant of the type known as food extracts.
3 . A composition according to claim 2 , wherein the prostacyclin promoter comprises one or more of curcumin, resveratrol, pycnogenol and rosmarinic acid.
4 . A regimen for treating a disease that is responsive to inhibition of cyclooxygenase-2, comprising administering to a patient suffering from such a disease the combination of the invention comprising a selective inhibitor of COX-2 and a prostacyclin promoter in amounts and at intervals effective to therapeutically inhibit COX-2 while maintaining a therapeutically significant level of prostacyclin production.
5 . A regimen for treating a disease that is responsive to inhibition of cyclooxygenase-2, comprising administering to a patient suffering from such a disease the combination of the invention comprising a selective inhibitor of COX-2 and a source of omega-3 fatty acid to serve as a substrate for prostacyclin formation, the amounts and intervals of administration being effective to therapeutically benefit the patient.
6 . A regimen for treating a disease that is responsive to inhibition of cyclooxygenase-2, comprising administering to a patient suffering from such a disease the combination of the invention comprising a selective inhibitor of COX-2 with extracted anti-inflammatory agents from plant tissue, the amounts and intervals of administration being effective to therapeutically benefit the patient.
7 . A regimen according to claim 6 wherein the extracted anti-inflammatory agents from plant tissue comprises one or more of curcumin, resveratrol, pycnogenol and rosmarinic acid.