A TRIACYLGLYCERIDE TO DELIVER HEALTH PROMOTING FATTY ACIDS TO THE UPPER GASTROINTESTINAL TRACT AND SKIN
Improved triglyceride compositions, bearing both omega-3-usaturated fatty acids and short chain fatty acids, are prepared according to the formulae: wherein, each R, independently, is a fatty acid residue, either saturated or unsaturated, having between 2 and 40 carbons; each R′, independently, is a long chain omega-3-unsaturated fatty acid residue having between 16 and 40 carbons, preferably 18 to 22 carbons; and each R″, independently, is a short chain acid residue having 2 to 5 carbons, preferably 2 to 4 carbons, most preferably 2 to 3 carbons. Also described is a regimen for treating a medical problem associated with less than healthy stomach tissue that is responsive to treatment with a triglyceride mixture as defined above, in amounts and at intervals effective to therapeutically improve the health of the stomach tissue. In another aspect the compositions are used in a regime for treating skin to increase skin cell turnover, to provide nourishment to epithelial cells and reduce inflammation. The regime comprises topically administering to a mammal a triglyceride mixture as defined above, in amounts and at intervals effective for these purposes.
1 . Improved triglyceride compositions, bearing both omega-3-usaturated fatty acids and short chain fatty acids, according to any of the formulae:
wherein,
each R, independently, is a fatty acid residue, either saturated or unsaturated, having between 2 and 40 carbons;
each R′, independently, is a long chain omega-3-unsaturated fatty acid residue having between 16 and 40 carbons, preferably 18 to 22 carbons; and
each R″, independently, is a short chain acid residue having 2 to 5 carbons, preferably 2 to 4 carbons, most preferably 2 to 3 carbons.
2 . Improved triglyceride compositions according to claim 1 wherein at least some of the R groups comprise long chain omega-3-unsaturated fatty acid residues having between 16 and 40 carbons.
3 . Improved triglyceride compositions according to claim 2 wherein at least some of the R groups comprise long chain omega-3-unsaturated fatty acid residues having between 18 to 22 carbons
4 . Improved triglyceride compositions according to claim 1 wherein at least some of the R groups comprise short chain acid residues having 2 to 5 carbons.
5 . Improved triglyceride compositions according to claim 4 wherein at least some of the R groups comprise short chain acid residues having 2 to 3 carbons
6 . Improved triglyceride compositions according to claim 1 wherein at least some of the R groups comprise long chain saturated fatty acid residues having between 16 and 40 carbons.
7 . Improved triglyceride compositions according to claim 1 wherein at least some of the R groups comprise long chain saturated fatty acid residues having between 18 to 22 carbons.
8 . Improved triglyceride compositions according to claim 1 wherein at least some of the R groups comprise medium chain fatty acid residues having between 6 and 10 carbons.
9 . A regimen for treating a medical problem associated with less than healthy stomach tissue that is responsive to treatment with a triglyceride mixture as defined above, in amounts and at intervals effective to therapeutically improve the health of the stomach tissue.
10 . A regimen that improves the outcome of patients with a condition or disease connected with fibromylagia, Chron's disease, irritable bowel syndrome and other inflammatory conditions in the gastrointestinal tract, comprising orally administering to a patient so affected a triglyceride mixture as defined above, in amounts and at intervals effective to therapeutically improve the noted condition or disease.
11 . A regime wherein the lipids in claim 1 are combined with NSAID's to help prevent the gastrointestinal side effects of the drugs comprising orally administering to a patient so affected a triglyceride mixture as defined above with an NSAID, in amounts and at intervals effective to therapeutically improve the noted condition or disease.
12 . A regimen for treating skin to increase skin cell turnover, and reduce inflammation and/or to provide nourishment to epithelial cells, comprising topically administering to a mammalian skin a triglyceride mixture as defined in claim 1 , in amounts and at intervals effective for these purposes.