COMPOSITIONS CONTAINING AN INTESTINAL TREFOIL PEPTIDE AND A MUCOADHESIVE
The invention features compositions containing an intestinal trefoil peptide and a mucoadhesive excipient. Such compounds are useful, e.g., for the treatment or prevention of lesions. Compositions containing an intestinal trefoil peptide and a mucoadhesive excipient may be formulated in combination with one or more additional therapeutic agents.
1 . A composition comprising an intestinal trefoil peptide and a mucoadhesive excipient.
2 . The composition of claim 1 , wherein said mucoadhesive comprises a water-soluble polymer.
3 . The composition of claim 1 , wherein said mucoadhesive comprises a polysaccharide.
4 . The composition of claim 1 , wherein said composition comprises a solution.
5 . The composition of claim 1 , wherein said composition comprises a suspension.
6 . The composition of claim 1 , wherein said intestinal trefoil peptide is spasmolytic polypeptide, pS2, or intestinal trefoil factor.
7 . The composition of claim 6 , wherein said intestinal trefoil peptide is intestinal trefoil factor.
8 . The composition of claim 7 , wherein said intestinal trefoil factor is human intestinal trefoil factor.
9 . The composition of claim 1 , wherein said composition further comprises a second therapeutic agent.
10 . The composition of claim 9 , wherein said second therapeutic agent is an anti-inflammatory agent, an antibacterial agent, an antiviral agent, an antifungal agent, a topical antiseptic, an analgesic, or a steroid.
11 . The composition of claim 10 , wherein said anti-inflammatory agent is acetaminophen, aspirin, ibuprofen, phenylbutazone, indomethacin, sulindac, diclofenac, or naproxen.
12 . The composition of claim 10 , wherein said antibacterial agent is a penicillin, a cephalosporin, a tetracycline, an aminoglycoside, a macrolide, a fluoroquinolone, chloramphenicol, clindamycin, cycloserine, isoniazid, rifampin, or vancomycin.
13 . The composition of claim 10 , wherein said antiviral agent is 1,-D-ribofuranosyl-1,2,4-triazole-3 carboxamide, 9->2-hydroxy-ethoxy methylguanine, adamantanamine, 5-iodo-2′-deoxyuridine, trifluorothymidine, interferon, adenine arabinoside, a protease inhibitor, a thymadine kinase inhibitor, a sugar or glycoprotein synthesis inhibitor, a structural protein synthesis inhibitor, an attachment or adsorption inhibitor, acyclovir, penciclovir, valacyclovir, or ganciclovir.
14 . The composition of claim 10 , wherein said antifungal agent is amphotericin B, butylparaben, clindamycin, econaxole, fluconazole, flucytosine, griseofuilvin, nystatin, or ketoconazole.
15 . The composition of claim 10 , wherein said topical antiseptic is povidone-iodine or benzalkonium chloride.
16 . The composition of claim 10 , wherein said analgesic is procaine, lidocaine, tetracaine, dibucaine, benzocaine, p-buthylaminobenzoic acid 2-(diethylamino) ethyl ester HCl, mepivacaine, piperocaine, dyclonine, morphine, codeine, hydrocodone, or oxycodone.
17 . The composition of claim 10 , wherein said steroid is triamcinolone, hydrocortisone, fluticasone, or beclomethasone.
18 . The composition of claim 1 , wherein said intestinal trefoil peptide is present in a therapeutically effective amount.
19 . The composition of claim 18 , wherein said composition comprises 10 mg of intestinal trefoil peptide.
20 . The composition of claim 18 , wherein said composition comprises 100 mg of intestinal trefoil peptide.