Granted Patent
B2
US 7,790,693 · App. 11/292,549 · Granted Sep 7, 2010
Glucose-transport related genes, polypeptides, and methods of use thereof
Assignee:
University of Massachusetts
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Abstract
Methods and compositions for modulating glucose transport are provided herein.
Claims (4)
1. A method for increasing insulin-stimulated glucose uptake in a cell in vitro, the method comprising:
administering to the cell an inhibitory RNA that decreases expression or activity of Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) in an amount sufficient to increase insulin-stimulated glucose uptake in the cell, thereby increasing insulin-stimulated glucose uptake in the cell.
2. The method of claim 1 , wherein the Map4k4 is human Map4k4.
3. The method of claim 1 , wherein the cell is an adipocyte.
Assignments (3)
CONFIRMATORY LICENSE
Recorded Apr 1, 2013
From: UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 030128/0012 →
CONFIRMATORY LICENSE
Recorded Mar 13, 2009
From: UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 022396/0176 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 30, 2006
From: CZECH, MICHAEL P.; POWELKA, AIMEE; GUILHERME, ADILSON L.; TANG, XIAOQING
To: UNIVERSITY OF MASSACHUSETTS
Reel/Frame 017412/0631 →
Continuity (2)
Provisional Application
6063246200
· Dec 2, 2004