Nematode phosphoethanolamine N-methyltransferase-like sequences
Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
1. An isolated nucleic acid molecule comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:12.
2. The nucleic acid molecule of claim 1 wherein the isolated nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:18.
3. The isolated nucleic acid molecule of claim 1 wherein the polypeptide consists of the amino acid sequence of SEQ ID NO:12.
4. A vector comprising the isolated nucleic acid molecule of claim 1 .
5. The vector of claim 4 wherein the vector is an expression vector.
6. An isolated recombinant host cell comprising the vector of claim 4 or claim 5 .