System and method for treating biological tissue with a plasma gas discharge
View Patent ↗Devices and methods for treating biological tissue using a plasma gas-discharge are disclosed herein. An electrode for igniting a gas flow to form a plasma gas-discharge, wherein the electrode is configured within the device such that upon encountering a surface of the biological tissue by the electrode, a path of current from the electrode to the surface of the biological tissue is formed, thereby igniting the gas flow and forming the plasma gas-discharge. In some embodiments, electromagnetic interactions between the treated biological tissue and the plasma gas discharge traversing the electromagnetic interaction gap shape the profile of the plasma gas discharge. According to some embodiments, the device includes an electrode for igniting gas of the gas flow, and electromagnetic interactions between the electrode and the skin determine, at least in part, the electromagnetic interactions that shape the profile of the plasma gas discharge. In some embodiments, the device further includes a housing for providing support for the electrode, wherein the electrode is disposed relative to the housing such that the electrode is substantially electrically unshielded by the housing, and the electrode is positioned to electromagnetically interact with a surface of the biological tissue to shape, at least in part, the plasma profile. According to some embodiments, the presently disclosed device includes a dual-purpose nozzle-electrode for gas delivery and for igniting the gas flow. A method of transdermal ion delivery of a plasma flux to biological tissue as a means of treating the biological tissue is also provided.
1. A device for treating biological tissue, the device comprising:
(a) a device electrode;
(b) an RF power generator configured to produce RF power directed to the device electrode so as to ignite a gas flow, thereby generating a diffusive plasma gas discharge within the gas flow in an interaction gap between the device electrode and the biological tissue, the diffusive plasma gas discharge having a ratio of ions to neutrals within the generated plasma gas-discharge that is less than 0.01;
(c) an impedance matching network configured to reduce reflection of the RF power produced by the RF power generator from a surface of the biological tissue to the RF power generator;
(d) a transmission line;
(e) a resonator; and
(f) device housing for providing support for the device electrode, wherein:
(i) the device operates at or above atmospheric pressure;
(ii) the device electrode is substantially electrically unshielded by the device housing;
(iii) the impedance matching network, the resonator and the transmission line electrically connect the device electrode to the RF power generator;
(iv) the impedance matching network, the resonator and the transmission line are configured to operate so that, prior to the ignition of the gas flow, distortions by the biological tissue of the RF field of the RF power generated by the RF power generator create a stronger field within the interaction gap, thereby triggering the ignition of the gas flow to produce the diffusive plasma gas discharge; and
(v) the RF power generator is configured to operate, after the ignition of the gas flow, by way of the impedance matching network, the resonator and the transmission line to sustain the gas plasma discharge.
2. The device of claim 1 wherein the device electrode is configured so that the diffusive plasma gas-discharge is shaped by the electromagnetic interaction between the device electrode and the surface of the biological tissue.
3. The device of claim 1 wherein the device electrode is a nozzle-electrode including a nozzle portion adapted to receive the gas flow.
4. The device of claim 1 , wherein the device is configured so that a dissipation of the produced RF power is 85-95% in the plasma gas discharge and 5-15% to the surface of the biological tissue.
5. The device of claim 1 , the device is configured so that when the device electrode is several centimeters from the surface of the biological tissue a real dimension of a surface of biological tissue interacting with an RF field of the RF power is between 20 and 40cm 2 .
6. The device of claim 1 , wherein the device is configured so that before the ignition of the gas flow, 80-90% of incident power from the RF power generator is reflected by the biological tissue surface and during an operation stage of the device between 2and 4% of the incident power is reflected by the biological tissue surface.
7. The device of claim 1 , wherein the device is configured to operate to provide a very low current density having a peak current density between 100 and 700 mA/cm 2 and an average value of between 10 and 200 mA/cm 2 .