Nitrogen-containing aromatic derivatives
Compounds represented by the following general formula: [wherein A g is an optionally substituted 5- to 14-membered heterocyclic group, etc.; X g is —O—, —S—, etc.; Y g is an optionally substituted C 6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and T g1 is a group represented by the following general formula: (wherein E g is a single bond or —N(R g2 )—, R g1 and R g2 each independently represent a hydrogen atom, an optionally substituted C 1-6 alkyl group, etc. and Z g represents a C 1-8 alkyl group, a C 3-8 alicyclic hydrocarbon group, a C 6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.
1 .- 42 . (canceled)
43 . A process for preparing a compound represented by the formula:
a pharmacologically acceptable salt or hydrate thereof wherein:
R 1 and R 2 are each independently a hydrogen atom, an optionally substituted C 1-6 alkyl group, an optionally substituted C 2-6 alkenyl group, an optionally substituted C 2-6 alkynyl group, an optionally substituted C 3-8 alicyclic hydrocarbon group, an optionally substituted C 2-7 acyl group or an optionally substituted C 2-7 alkoxycarbonyl group;
Z 12 is a hydrogen atom, an optionally substituted C 1-6 alkyl group, an optionally substituted C 2-6 alkenyl group, an optionally substituted C 2-6 alkynyl group, an optionally substituted C 3-8 alicyclic hydrocarbon group, an optionally substituted C 6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, an optionally substituted 5- to 14-membered aromatic heterocyclic group or a group represented by the formula:
wherein Z 31 , Z 33 and Z 34 are each independently a methylene group, —CO—, —NH— or —O—, and Z 32 is a single bond, a methylene group, —CO—, —NH— or —O—; and
wherein Z 12 is not pyrazolyl;
R 300 and R 301 are each independently a hydrogen atom, a halogen atom, a cyano group, a nitro group, an amino group, an optionally substituted C 1-6 alkyl group, an optionally substituted C 3-8 alicyclic hydrocarbon group, an optionally substituted C 1-6 alkoxy group, an optionally substituted C 2-7 alkoxycarbonyl group, a formyl group, a group represented by the formula
wherein V 300 and V 301 are each independently a hydrogen atom or an optionally substituted C 1-6 alkyl group, or an optionally substituted C 2-7 acyl group;
R a11 is a group represented by the formula -V a21 -V a22 -V a23 , wherein:
V a21 is an optionally substituted C 1-6 alkylene group, a single bond or a group represented by the formula:
V a22 is a single bond, an oxygen atom, a sulfur atom, —CO—, —SO—, —SO 2 —, —CONR a14 —, —SO 2 NR a14 —, —NR a14 SO 2 —, —NR a14 CO— or —NR a14 —;
wherein R a14 is a hydrogen atom, an optionally substituted C 1-6 alkyl group or an optionally substituted C 3-8 alicyclic hydrocarbon group; and
V a23 is a hydrogen atom, an optionally substituted C 1-6 alkyl group, an optionally substituted C 2-6 alkenyl group, an optionally substituted C 2-6 alkynyl group, an optionally substituted C 3-8 alicyclic hydrocarbon group, an optionally substituted C 6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group or an optionally substituted 5- to 14-membered aromatic heterocyclic group; and
R a12 is a cyano group or a group represented by the formula:
wherein:
V a11 is —CO— or —SO 2 —; and
V a12 , V a13 and V a14 are each independently a hydrogen atom, an optionally substituted C 1 — 6 alkyl group, an optionally substituted C 2-6 alkenyl group, an optionally substituted C 2-6 alkynyl group, an optionally substituted C 3-8 alicyclic hydrocarbon group, an optionally substituted C 6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group or an optionally substituted 5- to 14-membered aromatic heterocyclic group,
which comprises reacting a compound represented by the formula:
with a compound represented by the formula:
44 . The process according to claim 43 , further comprising the step of adding a base.