Heterocyclic substituted pyridine or phenyl compounds with CXCR3 antagonist activity
View Patent ↗The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prod rug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: or a pharmaceutically acceptable salt, solvate or ester thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, zenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
1. A compound having the structure shown in Formula 1
or a pharmaceutically acceptable salt, wherein:
Z is N, NO, or NOH;
G represents a 5-membered heteroaryl or heterocyclenyl ring containing at least one —C═N— moiety as part of said heteroaryl or heterocyclenyl ring, said heteroaryl or heterocyclenyl ring optionally additionally containing on the ring one or more moieties which can be the same or different, each being independently selected from the group consisting of N, N(→O), O, S, S(O) and S(O 2 ), further wherein said heteroaryl or heterocyclenyl ring can be either (i) unsubstituted, or (ii) optionally independently substituted on one or more ring carbon atoms with one or more R 9 substituents, or on one or more ring nitrogen atoms with one or more R 8 substituents, wherein said R 8 and R 9 substituents can be the same or different;
R 3 , R 4 , R 6 and R 29 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, alkylaryl, aralkyl, —CN, CF 3 , haloalkyl, cycloalkyl, halogen, hydroxyalkyl, —N═CH—(R 31 ), —C(═O)N(R 30 ) 2 , —N(R 30 ) 2 , —OR 30 , —SO 2 (R 31 ), —N(R 30 )C(═O)N(R 30 ) 2 and —N(R 30 )C(═O)R 31 ;
the R 8 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, alkenyl, alkylaryl, arylalkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, —(CH 2 ) q OH, —(CH 2 ) q OR 31 , —(CH 2 ) q NH 2 , —(CH 2 ) q NHR 31 , —(CH 2 ) q C(═O)NHR 31 , —(CH 2 ) q SO 2 R 31 , —(CH 2 ) q NSO 2 R 31 , —(CH 2 ) q C(═O)OR 31 , and —(CH 2 ) q SO 2 NHR 31 ;
the R 9 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, alkenyl, alkylaryl, arylalkyl, alkoxy, amidinyl, aryl, cycloalkyl, cyano, heteroaryl, heterocyclyl, hydroxyl, —C(═O)N(R 30 ) 2 , —C(═S)N(R 30 ) 2 , —C(═O)alkyl, —(CH 2 ) q OH, —(CH 2 ) q OR 31 , —(CH 2 ) q NH 2 , —(CH 2 ) q NHR 31 , —(CH 2 ) q C(═O)NHR 31 , —(CH 2 ) q SO 2 R 31 , —(CH 2 ) q NSO 2 R 31 , —(CH 2 ) q SO 2 NHR 31 , —N(R 30 ) 2 , —N(R 30 )S(O 2 )R 31 , —N(R 30 )C(═O)N(R 30 ) 2 , —OR 30 , —SO 2 (R 31 ), —SO 2 N(R 30 ) 2 , ═O and ═S;
the R 10 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, cycloalkyl, aryl, heteroaryl, heterocyclenyl, heterocyclyl, alkylaryl, arylalkyl, —CO 2 H, hydroxyalkyl, —C(═O)N(R 30 ) 2 , —(CH 2 ) q OH, —(CH 2 ) q OR 31 , —OR 30 , halogen, ═O, and —C(═O)R 31 ;
the R 11 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclenyl, alkylaryl, arylalkyl, carboxamide, CO 2 H, —(CH 2 ) q OH, —(CH 2 ) q OR 31 , —OR 30 , halogen, ═O, and —C(═O)R 31 ;
R 12 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, —CN, —C(═O)N(R 30 ) 2 , —(CH 2 ) q OH, —(CH 2 ) q OR 31 and —S(O 2 )R 31 ;
ring D is a five to nine membered cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclenyl or heterocyclyl ring having 0-4 heteroatoms independently selected from O, S or N, wherein ring D is unsubstituted or optionally substituted with 1-5 independently selected R 20 moieties;
the R 20 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, alkenyl, alkylaryl, alkynyl, alkoxy, alkylamino, alkylthiocarboxy, alkylheteroaryl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxycarbonyl, aminoalkyl, amidinyl, aralkyl, aralkenyl, aralkoxy, aralkoxycarbonyl, aralkylthio, aryl, aroyl, aryloxy, cyano, cycloalkyl, cycloalkenyl, formyl, guanidinyl, halogen, haloalkyl, heteroalkyl, heteroaryl, heterocyclyl, heterocyclenyl, hydroxyalkyl, hydroxamate, nitro, trifluoromethoxy, —(CH 2 ) q OH, —(CH 2 ) q OR 31 , —(CH 2 ) q NH 2 , —(CH 2 ) q NHR 31 , —(CH 2 ) q C(═O)NHR 31 , —(CH 2 ) q SO 2 R 31 , —(CH 2 ) q NSO 2 R 31 , —(CH 2 ) q SO 2 NHR 31 , —alkynylC(R 31 ) 2 OR 31 , —C(═O)R 30 , —C(═O)N(R 30 ) 2 , —C(═NR 30 )NHR 30 , —C(═NOH)N(R 30 ) 2 , —C(═NOR 31 )N(R 30 ) 2 , —C(═O)OR 30 , —N(R 30 ) 2 , —N(R 30 )C(═O)R 31 , —NHC(═O)N(R 30 ) 2 , —N(R 30 )C(═O)OR 31 , —N(R 30 )C(═NCN)N(R 30 ) 2 , —N(R 30 )C(═O)N(R 30 )SO 2 (R 31 ), —N(R 30 )C(═O)N(R 30 ) 2 , —N(R 30 )SO 2 (R 31 ), —N(R 30 )S(O) 2 N(R 30 ) 2 , —OR 30 , —OC(═O)N(R 30 ) 2 , —SR 30 , —SO 2 N(R 30 ) 2 , —SO 2 (R 31 ), —OSO 2 (R 31 ), and —OSi(R 30 ) 3 ; or alternatively two R 20 moieties are linked together to form a five or six membered aryl, cycloalkyl, heterocyclyl, heterocyclenyl, or heteroaryl ring wherein said five or six membered aryl, cycloalkyl, heterocyclyl, heterocyclenyl, or heteroaryl ring is fused to ring D and the fused ring is optionally substituted with 0-4 R 21 moieties;
the R 21 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, alkenyl, alkylaryl, alkynyl, alkoxy, alkylamino, alkylthiocarboxy, alkylheteroaryl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxycarbonyl, aminoalkyl, amidinyl, aralkyl, aralkenyl, aralkoxy, aralkoxycarbonyl, aralkylthio, aryl, aroyl, aryloxy, carboxamido, cyano, cycloalkyl, cycloalkenyl, formyl, guanidinyl, halogen, haloalkyl, heteroalkyl, heteroaryl, heterocyclyl, heterocyclenyl, hydroxyalkyl, hydroxamate, nitro, trifluoromethoxy, —(CH 2 ) q OH, —(CH 2 ) q OR 31 , —(CH 2 ) q NH 2 , —(CH 2 ) q NHR 31 , —(CH 2 ) q C(═O)NHR 31 , —(CH 2 ) q SO 2 R 31 , —(CH 2 ) q NSO 2 R 31 , —(CH 2 ) q SO 2 NHR 31 , -alkynylC(R 31 ) 2 OR 31 , —C(═O)R 30 , —C(═O)N(R 30 ) 2 , —C(═NR 30 )NHR 30 , —C(═NOH)N(R 30 ) 2 , —C(═NOR 31 )N(R 30 ) 2 , —C(═O)OR 30 , —N(R 30 ) 2 , —N(R 30 )C(═O)R 31 , —NHC(═O)N(R 30 ) 2 , —N(R 30 )C(═O)OR 31 , —N(R 30 )C(═NCN)N(R 30 ) 2 , —N(R 30 )C(═O)N(R 30 )SO 2 (R 31 ), —N(R 30 )C(═O)N(R 30 ) 2 , —N(R 30 )SO 2 (R 31 ), —N(R 30 )S(O) 2 N(R 30 ) 2 , —OR 30 , —OC(═O)N(R 30 ) 2 , —SR 30 , —SO 2 N(R 30 ) 2 , —SO 2 (R 31 ), —OSO 2 (R 31 ), and —OSi(R 30 ) 3 ;
Y is selected from the group consisting of —(CR 13 R 13 ) r —, —CHR 13 C(═O)—, —(CHR 13 ) r O—, —(CHR 13 ) r N(R 30 )—, —C(═O)—, —C(═NR 30 )—, —C(═N—OR 30 )—, —CH(C(═O)NHR 30 )—, CH-heteroaryl-, —C(R 13 R 13 ) r C(R 13 )═C(R 13 )—, —(CHR 13 ) r C(═O)— and —(CHR 13 ) r N(H)C(═O)—; or alternatively Y is cycloalkyl, heterocyclenyl, or heterocyclyl wherein the cycloalkyl, heterocyclenyl, or heterocyclyl is fused with ring D;
the R 13 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, alkylaryl, cycloalkyl, alkoxy, aryl, heteroaryl, heterocyclenyl, heterocyclyl, spiroalkyl, —CN, —CO 2 H, —C(═O)R 30 , —C(═O)N(R 30 ) 2 , —(CHR 30 ) q OH, —(CHR 30 ) q OR 31 , —(CHR 30 ) q NH 2 , —(CH R 30 ) q NHR 31 , —(CH 2 ) q C(═O)NHR 31 , —(CH 2 ) q SO 2 R 31 , —(CH 2 ) q NSO 2 R 31 , —(CH 2 ) q SO 2 NHR 31 , —NH 2 , —N(R 30 ) 2 , —N(R 30 )C(═O)N(R 30 ) 2 , —N(R 30 )SO 2 (R 31 ), —OH, OR 30 , —SO 2 N(R 30 ) 2 , and —SO 2 (R 31 );
the R 30 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, alkylaryl, aryl, aralkyl, cycloalkyl, CN, —(CH 2 ) q OH, —(CH 2 ) q Oalkyl, —(CH 2 ) q Oalkylaryl, —(CH 2 ) q Oaryl, —(CH 2 ) q Oaralkyl, —(CH 2 ) q Ocycloalkyl, —(CH 2 ) q NH 2 , —(CH 2 ) q NHalkyl, —(CH 2 ) q N(alkyl) 2 , —(CH 2 ) q NHalkylaryl, —(CH 2 ) q NHaryl, —(CH 2 ) q NHaralkyl, —(CH 2 ) q NHcycloalkyl, —(CH 2 ) q C(═O)NHalkyl, —(CH 2 ) q C(═O)N(alkyl) 2 , —(CH 2 ) q C(═O)NHalkylaryl, —(CH 2 ) q C(═O)NHaryl, —(CH 2 ) q C(═O)NHaralkyl, —(CH 2 ) q C(═O)NHcycloalkyl, —(CH 2 ) q SO 2 alkyl, —(CH 2 ) q SO 2 alkylaryl, —(CH 2 ) q SO 2 aryl, —(CH 2 ) q SO 2 aralkyl, —(CH 2 ) q SO 2 cycloalkyl, —(CH 2 ) q NSO 2 alkyl, —(CH 2 ) q NSO 2 alkylaryl, —(CH 2 ) q NSO 2 aryl, —(CH 2 ) q NSO 2 aralkyl, —(CH 2 ) q NSO 2 cycloalkyl, —(CH 2 ) q SO 2 NHalkyl, —(CH 2 ) q SO 2 NHalkylaryl, —(CH 2 ) q SO 2 NHaryl, —(CH 2 ) q SO 2 NHaralkyl, —(CH 2 ) q SO 2 NHcycloalkyl, heterocyclenyl, heterocyclyl, and heteroaryl;
the R 31 moieties can be the same or different, each being independently selected from the group consisting of alkyl, alkylaryl, aryl, aralkyl, cycloalkyl, —(CH 2 ) q OH, —(CH 2 ) q Oalkyl, —(CH 2 ) q Oalkylaryl, —(CH 2 ) q Oaryl, —(CH 2 ) q Oaralkyl, —(CH 2 ) q Ocycloalkyl, —(CH 2 ) q NH 2 , —(CH 2 ) q NHalkyl, —(CH 2 ) q N(alkyl) 2 , —(CH 2 ) q NHalkylaryl, —(CH 2 ) q NHaryl, —(CH 2 ) q NHaralkyl, —(CH 2 ) q NHcycloalkyl, —(CH 2 ) q C(═O)NHalkyl, —(CH 2 ) q C(═O)N(alkyl) 2 , —(CH 2 ) q C(═O)NHalkylaryl, —(CH 2 ) q C(═O)NHaryl, —(CH 2 ) q C(═O)NHaralkyl, —(CH 2 ) q C(═O)NHcycloalkyl, —(CH 2 ) q SO 2 alkyl, —(CH 2 ) q SO 2 alkylaryl, —(CH 2 ) q SO 2 aryl, —(CH 2 ) q SO 2 aralkyl, —(CH 2 ) q SO 2 cycloalkyl, —(CH 2 ) q NSO 2 alkyl, —(CH 2 ) q NSO 2 alkylaryl, —(CH 2 ) q NSO 2 aryl, —(CH 2 ) q NSO 2 aralkyl, —(CH 2 ) q NSO 2 cycloalkyl, —(CH 2 ) q SO 2 NHalkyl, —(CH 2 ) q SO 2 NHalkylaryl, —(CH 2 ) q SO 2 NHaryl, —(CH 2 ) q SO 2 NHaralkyl, —(CH 2 ) q SO 2 NHcycloalkyl, heterocyclenyl, heterocyclyl, and heteroaryl;
m is 0 to 4;
n is 0 to 4;
each q can be the same or different, each being independently selected from 1 to 5; and
r is 1 to 4;
with the proviso that there are no two adjacent double bonds in any ring, and that when a nitrogen is substituted by two alkyl groups, said two alkyl groups may be optionally joined to each other to form a ring.
2. The compound according to claim 1 , wherein ring G is a a dihydroimidazole, imidazole, dihydrooxazole, oxazole, dihydrooxadiazole, oxadiazole, dihydrothiazole, thiazole, triazole or tetrazole ring.
3. The compound according to claim 1 , wherein Z is N.
4. The compound according to claim 1 , wherein G is selected from the group consisting of:
wherein a single bond or double bond.
5. The compound according to claim 1 , wherein R 3 is selected from the group consisting of H, alkyl, haloalkyl, hydroxyalkyl, halogen, —N(R 30 ) 2 , —OR 30 and —CF 3 .
6. The compound according to claim 5 , wherein R 3 is selected from the group consisting of H, —CH 3 , —CH 2 CH 3 , cyclopropyl, —F, —Cl, OCH 3 , OCF 3 and CF 3 .
7. The compound according to claim 1 , wherein R 4 is selected from the group consisting of H, alkyl, halogen or CF 3 .
8. The compound according to claim 1 , wherein R 6 is selected from the group consisting of H, alkyl, halogen, hydroxyalkyl, —CN, —N(R 30 ) 2 , —OR 30 , —N═CH-alkyl, and —NR 30 C(═O)alkyl.
9. The compound according to claim 8 , wherein R 6 is selected from the group consisting of H, —NH 2 , —CH 3 , —CN and —F.
10. The compound according to claim 1 , wherein R 8 is selected from the group consisting of H, alkyl, alkenyl, arylalkyl, cycloalkyl, —(CH 2 ) q OH, —(CH 2 ) q OR 31 , —(CH 2 ) q NH 2 , —(CH 2 ) q NHR 31 , —(CH 2 ) q C(═O)NHR 31 , —(CH 2 ) q SO 2 R 31 , —(CH 2 ) q NSO 2 R 31 , or —(CH 2 ) q SO 2 NHR 31 .
11. The compound according to claim 1 , wherein R 9 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, cycloalkyl, —C(═O)N(H)R 30 , —C(═O)alkyl, —(CH 2 ) q OH, —(CH 2 ) q OR 31 , —(CH 2 ) q NH 2 , —(CH 2 ) q NHR 31 , —N(H)R 30 , —N(H)S(O 2 )R 31 , —N(H) C(═O)NH(R 30 ), —OR 30 , —SO 2 (R 31 ), and —SO 2 N(H)R 30 .
12. The compound according to claim 1 , wherein the R 9 moieties can be the same or different, each being independently selected from the group consisting of H, cyclopropyl, —CF 3 , —CH 3 , —CH 2 OH, —CH 2 CH 2 OH, —C(CH 3 ) 2 OH, —CH 2 CH 2 OCH 3 , —C(═O)OCH 2 CH 3 , —CH 2 NH 2 , —CH 2 CH 2 NH 2 , —CH 2 CH 2 NHSO 2 CH 3 , —CH 2 CH 2 SO 2 CH 3 , —C(═O)NH 2 , —C(═O)N(H)CH 2 CH 2 OH, —CH 2 N(H)C(═O)CF 3 , —C(═O)N(H)-cyclopropyl, —C(═O)N(H)CH 2 CF 3 , —NH 2 , —NHCH 3 , —N(CH 3 ) 2 , —N(H)CH 2 CH 3 , —N(H)CH(CH 3 ) 2 , —N(H)CH 2 CH 2 CH 3 , —N(H)CH 2 C(═O)OCH 3 , —N(H)CH 2 CH 2 OH, —N(H)CH 2 CH 2 NH 2 , —N(H)CH 2 CH 2 NHSO 2 CH 3 , —N(H)CH 2 CH 2 SO 2 CH 3 , —N(H)C(═O)N(H)CH 2 CH 3 , —N(H)CH 2 C(═O)NH 2 , —OCH 3 , ═S and ═O.
13. The compound according to claim 1 , wherein R 9 moieties can be the same or different, each being independently selected from the group consisting of H, —CF 3 , —CH 3 , —CH 2 CH 2 OH, —CH 2 CH 2 NH 2 , —NH 2 , —NHCH 3 , —N(H)CH 2 CH 3 , —N(H)CH(CH 3 ) 2 , —N(H)CH 2 CH 2 CH 3 , —N(H)CH 2 C(═O)OCH 3 , and —N(H)CH 2 CH 2 OH.
14. The compound according to claim 1 , wherein R 10 is selected from the group consisting of H, alkyl, aralkyl, hydroxyalkyl, and carbonyl.
15. The compound according to claim 14 , wherein R 10 is selected from the group consisting of —CH 3 , —CH 2 CH 3 and —CH 2 CH 2 CH 3 , and m is 0-2.
16. The compound according to claim 1 , wherein R 11 is selected from the group consisting of H, alkyl, hydroxyalkyl and carbonyl.
17. The compound according to claim 16 , wherein R 11 is H or —CH 3 .
18. The compound according to claim 1 , wherein R 12 is selected from the group consisting of H, CN, —C(═O)N(R 30 ) 2 and alkyl.
19. The compound according to claim 18 , wherein R 12 is selected from the group consisting of H, —CH 3 , CN and —CH 2 CH 3 .
20. The compound according to claim 1 , wherein the ring atoms of ring D are independently C or N and substituted by 0-4 R 20 moieties.
21. The compound according to claim 1 , wherein ring D is a 5 to 6 membered aryl, heteroaryl, heterocyclenyl, or heterocyclyl ring and substituted by 0-4 R 20 moieties.
22. The compound according to claim 1 , wherein the R 20 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, alkylaryl, alkynyl, alkoxy, alkylamino, alkylheteroaryl, alkylsulfinyl, alkoxycarbonyl, aminoalkyl, amidinyl, aralkyl, aralkoxy, aryl, aryloxy, cyano, cycloalkyl, cycloalkenyl, halogen, haloalkyl, heteroalkyl, heteroaryl, heterocyclyl, hydroxyalkyl, trifluromethyl, trifluoromethoxy, —(CH 2 ) q OR 31 , —(CH 2 ) q NHR 31 , —(CH 2 ) q C(═O)NHR 31 , —(CH 2 ) q SO 2 R 31 , —(CH 2 ) q NSO 2 R 31 , —(CH 2 ) q SO 2 NHR 31 , -alkynylC(R 31 ) 2 OR 31 , —C(═O)R 30 , —C(═O)N(R 30 ) 2 , —C(═O)OR 30 , —N(R 30 ) 2 , —N(R 30 )C(═O)R 31 , —NHC(═O)N(R 30 ) 2 , —N(R 30 )C(═O)OR 31 , —N(R 30 )C(═NCN)N(R 30 ) 2 , —N(R 30 )C(═O)N(R 30 ) 2 , —N(R 30 )SO 2 (R 31 ), —N(R 30 )SO 2 N(R 30 ) 2 , —OR 30 , —OC(═O)N(R 30 ) 2 , —SR 30 , —SO 2 N(R 30 ) 2 , —SO 2 (R 31 ), —OSO 2 (R 31 ), and —OSi(R 30 ) 3 .
23. The compound according to claim 1 , wherein the R 20 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, amino, halogen, CN, CH 3 , CF 3 , OCF 3 , —(CH 2 ) q OR 31 , —(CH 2 ) q NHR 31 , —(CH 2 ) q C(═O)NHR 31 , —(CH 2 ) q SO 2 R 31 , —(CH 2 ) q NSO 2 R 31 , —(CH 2 ) q SO 2 NHR 31 , -alkynylC(R 31 ) 2 OR 31 , —C(═O)R 30 , —C(═O)OR 30 , —N(R 30 ) 2 , —N(R 30 )C(═O)R 31 , —NHC(═O)N(R 30 ) 2 , —N(R 30 )C(═O)OR 31 , —N(R 30 )C(═NCN)N(R 30 ) 2 , —N(R 30 )C(═O)N(R 30 ) 2 , —OR 30 , —OC(═O)N(R 30 ) 2 , and —OSO 2 (R 31 ).
24. The compound according to claim 1 , wherein two R 20 moieties are linked together to form a five or six membered aryl, cycloalkyl, heterocyclenyl, heterocyclyl or heteroaryl ring wherein said five or six membered aryl, cycloalkyl, heterocyclenyl, heterocyclyl, and heteroaryl ring is fused to ring D and the fused ring is optionally substituted with 0 to 4 R 21 moieties.
25. The compound according to claim 1 , wherein the R 20 moieties can be the same or different, each being independently selected from the group consisting of H, —CN, —CH 3 , —CF 3 , —CH 2 OH, —CO 2 H, —CO 2 CH 3 , —NH 2 , —NHCH 3 , —OCF 3 , —OH, F, Cl, Br, —C(═NOH)NH 2 , —OCH 2 CH 2 S(O 2 )CH 3 , —C(═O)NH 2 ,
26. The compound according to claim 1 , wherein Y is selected from the group consisting of: —(CHR 13 ) r —, —(CR 13 R 13 ) r —, —C(═O)— and —CHR 13 C(═O)—.
27. The compound according to claim 1 , wherein Y is selected from the group consisting of: —CH 2 —, —CH(CH 3 )—, —CH(CH 2 OH)—, —C(═O)— and —CH(CO 2 alkyl)-.
28. The compound according to claim 1 , wherein m is 0-2.
29. The compound according to claim 1 , wherein n is 0-2.
30. The compound according to claim 1 , wherein q is 1 or 2.
31. The compound according to claim 1 , wherein r is 1 or 2.
32. The compound according to claim 1 , wherein ring G is selected from the group consisting of:
is a single bond or a double bond;
R 3 is selected from the group consisting of H, alkyl, haloalkyl, hydroxyalkyl, halogen, —N(R 30 ) 2 , —OR 30 and —CF 3 ;
R 6 is selected from the group consisting of H, alkyl, halogen, hydroxyalkyl, —CN, —N(R 30 ) 2 , —OR 30 , —N═CH-alkyl, and —NR 30 C(═O)alkyl;
R 9 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, cycloalkyl, —C(═O)N(H)R 30 , —C(═O)alkyl, —(CH 2 ) q OH, —(CH 2 ) q OR 31 , —(CH 2 ) q NH 2 , —(CH 2 ) q NHR 31 , —N(H)R 30 , —N(H)S(O 2 )R 31 , —N(H)C(═O)NH(R 30 ), —OR 30 , —SO 2 (R 31 ), and —SO 2 N(H)R 30 ;
R 10 is selected from the group consisting of H, alkyl, aralkyl, hydroxyalkyl, and carbonyl;
R 11 is selected from the group consisting of: H, alkyl, hydroxyalkyl, and carbonyl;
R 12 is selected from the group consisting of H, CN, —C(═O)N(R 30 ) 2 and alkyl;
ring D is a 5 to 6 membered aryl, heteroaryl, heterocyclenyl, or heterocyclyl ring and substituted by 0-4 R 20 moieties;
the R 20 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, amino, halogen, CN, CH 3 , CF 3 , OCF 3 , —(CH 2 ) q OR 31 , —(CH 2 ) q NHR 31 , —(CH 2 ) q C(═O)NHR 31 , —(CH 2 ) q SO 2 R 31 , —(CH 2 ) q NSO 2 R 31 , —(CH 2 ) q SO 2 NHR 31 , -alkynylC(R 31 ) 2 OR 31 , —C(═O)R 30 , —C(═O)OR 30 , —N(R 30 ) 2 , —N(R 30 )C(═O)R 31 , —NHC(═O)N(R 30 ) 2 , —N(R 30 )C(═O)OR 31 , —N(R 30 )C(═NCN)N(R 30 ) 2 , —N(R 30 )C(═O)N(R 30 ) 2 , —OR 30 , —OC(═O)N(R 30 ) 2 ,
Y is selected from the group consisting of: —CH 2 —, —CH(CH 3 )—, —CH(CH 2 OH)—, —C(═O)— and —CH(CO 2 alkyl)-;
m is 0-2;
n is 0-2;
q is 1 or 2; and
r is 1 or 2.
33. the compound according to claim 1 , selected from the group consisting of:
Compound
Number
STRUCTURE
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
21
22
23
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
or a pharmaceutically acceptable salt, solvate or ester thereof.
34. The compound according to claim 1 , wherein said compound is represented by structural Formula 2, Formula 3, Formula 4, Formula 5, Formula 6 or Formula 7:
or a pharmaceutically acceptable salt, or ester thereof, wherein:
the R 8 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, alkenyl, alkylaryl, arylalkyl, cycloalkyl, aryl, heteroaryl, heterocyclenyl, heterocyclyl, —(CH 2 ) q OH, —(CH 2 ) q OR 31 , —(CH 2 ) q NH 2 , —(CH 2 ) q NHR 31 , —(CH 2 ) q C(═O)NHR 3 , —(CH 2 ) q SO 2 R 31 , —(CH 2 ) q NSO 2 R 31 , or —(CH 2 ) q SO 2 NHR 31 ;
the R 9 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, arylalkyl, alkylaryl, cycloalkyl, heteroaryl, heterocyclenyl, heterocyclyl, —C(═O)N(H)R 30 , —C(═O)alkyl, —N(H)R 30 , —N(H)S(O 2 )R 31 , —N(H)C(═O)NH(R 30 ), —OR 30 , —SO 2 (R 31 ), ═O, ═S, and —SO 2 N(H)R 30 ;
L is C or N;
in Formula 4 is a single bond or a double bond; and
m, n, p, q, R 10 , R 11 , R 12 , R 20 and Y are as defined in claim 1 .
35. The compound according to claim 34 , wherein in Formulas 2, 3, 4, 5, 6 and 7, R 3 is selected from the group consisting of H, alkyl, haloalkyl, hydroxyalkyl, halogen, —N(R 30 ) 2 , —OR 30 and —CF 3 .
36. The compound according to claim 34 , wherein in Formulas 2, 3, 4, 5, 6 and 7, R 6 is selected from the group consisting of H, alkyl, halogen, —N(R 30 ) 2 , —OR 30 and —NR 1 C(═O)alkyl.
37. The compound according to claim 34 , wherein in Formulas 2, 3, 4, 5, 6 and 7, R 9 moieties are the same or different, each being independently selected from the group consisting of H, cyclopropyl, —CF 3 , —CH 3 , —CH 2 CH 3 , —CH 2 OH, —CH 2 CH 2 OH, —C(CH 3 ) 2 OH, —CH 2 CH 2 OCH 3 , —C(═O)OCH 2 CH 3 , —CH 2 NH 2 , —CH 2 CH 2 NH 2 , —CH 2 CH 2 NHSO 2 CH 3 , —CH 2 CH 2 SO 2 CH 3 , —C(═O)NH 2 , —C(═O)N(H)CH 2 CH 2 OH, —CH 2 N(H)C(═O)CF 3 , —C(═O)N(H)-cyclopropyl, —C(═O)N(H)CH 2 CF 3 , —NH 2 , —NHCH 3 , —N(CH 3 ) 2 , —N(H)CH 2 CH 3 , —N(H)CH(CH 3 ) 2 , —N(H)CH 2 CH 2 CH 3 , —N(H)CH 2 C(═O)OCH 3 , —N(H)CH 2 CH 2 OH, —N(H)CH 2 CH 2 NH 2 , —N(H)CH 2 CH 2 NHSO 2 CH 3 , —N(H)CH 2 CH 2 SO 2 CH 3 , —N(H)C(═O)N(H)CH 2 CH 3 , —N(H)CH 2 C(═O)NH 2 , ═O, ═S, and —OCH 3 .
38. The compound according to claim 35 , wherein in Formulas 2, 3, 4, 5, 6 and 7, R 10 is selected from the group consisting of H, alkyl, aralkyl, hydroxyalkyl, and carbonyl.
39. The compound according to claim 35 , wherein in Formulas 2, 3, 4, 5, 6 and 7, R 11 is selected from the group consisting of: H, alkyl and carbonyl.
40. The compound according to claim 35 , wherein in Formulas 2, 3, 4, 5, 6 and 7, R 12 is selected from the group consisting of H, —CH 3 , CN or —CH 2 CH 3 .
41. The compound according to claim 35 , wherein in Formulas 2, 3, 4, 5, 6 and 7, the R 20 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, amino, halogen, CN, CH 3 , CF 3 , OCF 3 , —(CH 2 ) q OR 31 , —(CH 2 ) q NHR 31 , —(CH 2 ) q C(═O)NHR 31 , —(CH 2 ) q SO 2 R 31 , —(CH 2 ) q NSO 2 R 31 , —(CH 2 ) q SO 2 NHR 31 , -alkynylC(R 31 ) 2 OR 31 , —C(═O)R 30 , —C(═O)OR 30 , —N(R 30 ) 2 , —N(R 30 )C(═O)R 31 , —NHC(═O)N(R 30 ) 2 , —N(R 30 )C(═O)OR 31 , —N(R 30 )C(═NCN)N(R 30 ) 2 , —N(R 30 )C(═O)N(R 30 ) 2 , —OR 30 , —OC(═O)N(R 30 ) 2 , —OSO 2 (R 31 ),
42. The compound according to claim 35 , wherein in Formulas 2, 3, 4, 5, 6 and 7, the R 20 moieties can be the same or different, each being independently selected from the group consisting of H, —CN, —CH 3 , —CF 3 , —CH 2 OH, —CO 2 H, —CO 2 CH 3 , —NH 2 , —NHCH 3 , —OCF 3 , —OH, F, Cl, Br, —C(═NOH)NH 2 , —OCH 2 CH 2 S(O 2 )CH 3 , —C(═O)NH 2 ,
43. The compound according to claim 35 , wherein in Formulas 2, 3, 4, 5, 6 and 7, L is carbon.
44. The compound according to claim 35 , wherein in Formulas 2, 3, 4, 5, 6 and 7, L is nitrogen.
45. The compound according to claim 35 , wherein in Formulas 2, 3, 4, 5, 6 and 7, Y is selected from the group consisting of: —CH 2 —, —C(═O)—, —CH(CH 2 OH)— and —CH(CO 2 alkyl)-.
46. The compound according to claim 35 , wherein in Formulas 2, 3, 4, 5, 6 and 7, R 3 is selected from the group consisting of H, alkyl, haloalkyl, hydroxyalkyl, halogen, —N(R 30 ) 2 , —OR 30 and —CF 3 ;
R 6 is selected from the group consisting of H, alkyl, halogen, —N(R 30 ) 2 , —OR 30 , and —NR 1 C(═O)alkyl;
the R 9 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, cycloalkyl, —C(═O)N(H)R 30 , —C(═O)alkyl, —N(H)R 30 , —N(H)S(O 2 )R 31 , —N(H)C(═O)NH(R 30 ), —OR 30 , —SO 2 (R 31 ), and —SO 2 N(H)R 30 ;
R 10 is selected from the group consisting of H, alkyl, aralkyl, hydroxyalkyl and carbonyl;
the R 20 moieties can be the same or different, each being independently selected from the group consisting of H, alkyl, amino, halogen, CN, CH 3 , CF 3 , OCF 3 , —(CH 2 ) q OR 31 , —(CH 2 ) q NHR 31 , —(CH 2 ) q C(═O)NHR 31 , —(CH 2 ) q SO 2 R 31 , —(CH 2 ) q NSO 2 R 31 , —(CH 2 ) q SO 2 NHR 31 , -alkynylC(R 31 ) 2 OR 31 , —C(═O)R 30 , —C(═O)OR 30 , —N(R 30 ) 2 , —N(R 30 )C(═O)R 31 , —NHC(═O)N(R 30 ) 2 , —N(R 30 )C(═O)OR 31 , —N(R 30 )C(═NCN)N(R 30 ) 2 , —N(R 30 )C(═O)N(R 30 ) 2 , —OR 30 , —OC(═O)N(R 30 ) 2 , and —OSO 2 (R 31 ),
Y is selected from the group consisting of: —CH 2 —, —C(═O)—, —CH(CH 2 OH)— and —CH(CO 2 alkyl)-;
m is 0-2;
q is 1 or 2; and
r is 1 or 2.
47. A compound according to claim 1 , selected from the group consisting of the following:
or a pharmaceutically acceptable salt, or ester thereof.
48. A compound according to claim 1 , selected from the group consisting of the following:
or a pharmaceutically acceptable salt, or ester thereof.
49. A compound having the structural formula selected from the group consisting of the following:
or a pharmaceutically acceptable salt, or ester thereof.
50. A compound according to claim 1 in purified form.