METHOD AND APPARATUS FOR DELIVERING EPINEPHRINE
A method of administering liquid medicine such as epinephrine to a patient includes administering a first dose followed by administering an optional second dose is described herein. Also described herein are devices useful for carrying out the methods described and kits containing these devices.
1 . A method of treating allergic emergency in a patient, comprising automatically injecting into a patient in need thereof a first dose of epinephrine comprising about 0.3 mL or about 0.15 mL of an epinephrine solution and optionally subsequently automatically injecting into the patient a second dose of epinephrine comprising about 0.3 mL or about 0.15 mL of the epinephrine solution, wherein the total amount of epinephrine delivered between the first and second doses is 0.3 mg or 0.6 mg.
2 . The method of claim 1 , wherein the concentration of the first dose is about 0.5 mg of epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution and the concentration of the second dose is about 0.5 mg epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution.
3 . The method of claim 2 , wherein the first dose of epinephrine consists essentially of about 0.3 mL of the epinephrine solution and the second dose of epinephrine consists essentially of about 0.3 mL of the epinephrine solution.
4 . The method of claim 2 , wherein the first dose of epinephrine consists essentially of about 0.15 mL of the epinephrine solution and the second dose of epinephrine consists essentially of about 0.15 mL of the epinephrine solution.
5 . The method of claim 1 , wherein the second dose is administered within 10 minutes of the first dose.
6 . The method of claim 1 , wherein the patient weighs at least about 30 Kg.
7 . The method of claim 1 , wherein the patient weighs at least about 15 Kg.
8 . A drug delivery device containing an epinephrine solution, wherein the device comprises means for delivering a first dose of about 0.3 mL or 0.15 mL of the epinephrine solution by automatic injection and means for delivering a second dose of about 0.3 mL or 0.15 mL of the epinephrine solution by automatic injection, wherein the total amount of epinephrine delivered between the first and second doses is 0.3 mg or 0.6 mg.
9 . The drug delivery device of claim 8 , wherein the concentration of the first dose is about 0.5 mg of epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution and the concentration of the second dose is about 0.5 mg epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution.
10 . The drug delivery device of claim 8 , wherein the device comprises means for delivering a first dose of about 0.3 mL of the epinephrine solution by automatic injection and means for delivering a second dose of about 0.3 mL of the epinephrine solution by automatic injection.
11 . The drug delivery device of claim 8 , wherein the device comprises means for delivering a first dose of about 0.15 mL of the epinephrine solution by automatic injection and means for delivering a second dose of about 0.15 mL of the epinephrine solution by automatic injection.
12 . A method of treating allergic emergency in a patient, comprising manually injecting into a patient in need thereof a first dose of epinephrine comprising about 0.3 mL or about 0.15 mL of an epinephrine solution and optionally subsequently manually injecting into the patient a second dose of epinephrine comprising about 0.3 mL or about 0.15 mL of the epinephrine solution, wherein the total amount of epinephrine delivered between the first and second doses is 0.3 mg or 0.6 mg.
13 . The method of claim 12 , wherein the concentration of the first dose is about 0.5 mg of epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution and the concentration of the second dose is about 0.5 mg epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution.
14 . The method of claim 13 , wherein the first dose of epinephrine consists essentially of about 0.3 mL of the epinephrine solution and the second dose of epinephrine consists essentially of about 0.3 mL of the epinephrine solution.
15 . The method of claim 13 , wherein the first dose of epinephrine consists essentially of about 0.15 mL of the epinephrine solution and the second dose of epinephrine consists essentially of about 0.15 mL of the epinephrine solution.
16 . The method of claim 12 , wherein the second dose is injected less than about 10 minutes after the first dose.
17 . The method of claim 12 , wherein the patient weighs at least about 30 Kg.
18 . The method of claim 12 , wherein the patient weighs at least about 15 Kg.
19 . A drug delivery device containing an epinephrine solution, wherein the device comprises means for delivering a first dose of about 0.3 mL or about 0.15 mL of the epinephrine solution by manual injection and means for delivering a second dose of about 0.3 mL or about 0.15 mL of the epinephrine solution by manual injection, wherein the total amount of epinephrine delivered between the first and second doses is 0.3 mg or 0.6 mg.
20 . The drug delivery device of claim 19 , wherein the concentration of the first dose is about 0.5 mg of epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution and the concentration of the second dose is about 0.5 mg epinephrine per mL of epinephrine solution or about 1.0 mg of epinephrine per mL of epinephrine solution.
21 . The drug delivery device of claim 19 , wherein the device comprises means for delivering a first dose of about 0.3 mL of the epinephrine solution by manual injection and means for delivering a second dose of about 0.3 mL of the epinephrine solution by manual injection.
22 . The drug delivery device of claim 19 , wherein the device comprises means for delivering a first dose of about 0.15 mL of the epinephrine solution by manual injection and means for delivering a second dose of about 0.15 mL of the epinephrine solution by manual injection.