Compositions Of Bakuchiol And Methods Of Making The Same
The present invention provides compositions of bakuchiol (UP246) having low levels of impurities, particularly furanocoumarin impurities. The present invention further provides improved methods for the isolation, purification and analysis of compositions of bakuchiol. Finally, the present invention provides methods for using the purified bakuchiol compositions and formulations thereof for the prevention and treatment of various diseases and conditions mediated by cyclooxygenase (COX), lipoxygenase (LOX), minor inflammatory conditions and various microbial infections. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.
1 . A composition comprised of bakuchiol, which is substantially free of furanocoumarin impurities.
2 . The composition of claim 1 wherein said bakuchiol is isolated from a plant.
3 . The composition of claim 2 wherein said plant is selected from the Psoralea genus of plants.
4 . The composition of claim 3 wherein said plant is selected from Psoralea corylifolia L. (Luguminosae) or Psoralea glandulosa L. (Papilionaceae).
5 . The composition of claim 3 wherein said composition is isolated from a plant part selected from seeds, stems, bark, twigs, tubers, roots, root bark, young shoots, rhixomes, flowers and other reproductive organs, leaves and other aerial parts and the whole plant.
6 . The composition of claim 1 wherein the amount of bakuchiol in said composition is the range of about 27% and 100% by weight.
7 . The composition of claim 6 wherein the amount of bakuchiol in said composition is at least 30%.
8 . The composition of claim 1 wherein said furanocoumarins are selected from psoralen and isopsoralen.
9 - 27 . (canceled)