Human bikunin
The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental bikunin, serine protease inhibitor domains, and fragments thereof.
1. A method for treating a chronic obstructive lung disease (COLD) comprising administering to a subject having the disease an effective amount of a polypeptide selected from the group consisting of SEQ ID NOs: 1, 4, 6 and 52.
2. The method of claim 1 , wherein the disease is emphysema.
3. The method of claim 1 , wherein the polypeptide is SEQ ID NO:6.
4. The method of claim 1 , wherein the polypeptide is SEQ ID NO:4.
5. The method of claim 1 , wherein the polypeptide is SEQ ID NO:1.
6. The method of claim 1 , wherein the polypeptide is SEQ ID NO:52.
7. A method for treating pulmonary emphysema comprising administering to a subject in need thereof an effective amount of a polypeptide, selected from the group consisting of SEQ ID NOs: 1, 4, 6 and 52.