Acetal phosphate-derived LPA mimics, PPARgamma activators, and autotaxin inhibitors
Disclosed are compositions that modulate the effects of extracellular LPA receptors, the intracellular PPARγ receptor, and autotaxin, and methods for their use.
1 . An LPA analog that acts as an agonist or antagonist of LPA 1 , LPA 1 , LPA 3 , PPARγ, and/or autotaxin, the LPA analog comprising an acetal phosphatidic acid.
2 . An LPA analog as described by claim 1 wherein the analog comprises
where R 1 is O or S, and R 2 is a straight or branched chain saturated or unsaturated, linear or cyclic hydrocarbon, substituted or unsubstituted, preferably C6 to C24, having an agonist or antagonist effect on LPA 1 , LPA 2 , LPA 3 , PPARγ, and/or autotaxin.
3 . An LPA analog as in claim 1 wherein the analog comprises a water soluble salt of an acetal phosphatidic acid.
4 . A therapeutic method of modulating an LPA-, PPARγ-, and/or autotaxin-mediated disease in a human or animal subject, the method comprising administering to the subject a therapeutically effective amount of an acetal phosphatidic acid having agonist or antagonist activity on LPA 1 , LPA 1 , LPA 3 , PPARγ, autotaxin, or a combination thereof.