IP Library › Granted Patent US 7,709,517
Granted Patent B2
US 7,709,517 · App. 11/433,829 · Granted May 4, 2010

Diarylhydantoin compounds

Assignee: The Regents of the University of California
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Quick Facts
Patent No.
US 7,709,517
App. No.
11/433,829
Granted
May 4, 2010
Kind
B2
Abstract

The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.

Claims (13)

1. A compound selected from the group consisting of

2. The compound of claim 1 having the formula

3. The compound of claim 1 , having the formula

4. The compound of claim 1 , having the formula

5. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 2 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.

6. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 3 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.

7. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 4 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.

8. A pharmaceutical acceptable salt of a compound according to claim 1 .

9. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt of a compound of claim 1 , and a pharmaceutically acceptable carrier or diluent.

10. A pharmaceutical composition according to claim 9 , wherein the compound is dissolved.

11. A pharmaceutical composition according to claim 9 , comprising a solvent.

12. A pharmaceutical composition according to claim 9 comprising one or more of dimethylsulfoxide (DSMO), polyethylene glycol (PEG), and water.

13. A pharmaceutical composition according to claim 9 , dimethylsulfoxide (DSMO), polyethylene glycol (PEG), and water.

Assignments (10)
CONFIRMATORY LICENSE Recorded Dec 23, 2009
From: UNIVERSITY OF CALIFORNIA LOS ANGELES
To: US ARMY, SECRETARY OF THE ARMY
Reel/Frame 023698/0580 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 16, 2009
From: HOWARD HUGHES MEDICAL INSTITUTE
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 023523/0895 →
CORRECTIVE ASSIGNMENT TO CORRECT THE NUMBER OF ASSIGNORS BY DELETING ASSIGNORS CHRIS TRAN AND JOHN WONGVIPAT PREVIOUSLY RECORDED ON REEL 022857 FRAME 0181. ASSIGNOR(S) HEREBY CONFIRMS THE CORRECT ASSIGNORS AS LISTED BELOW. Recorded Nov 3, 2009
From: JUNG, MICHAEL E.; CHEN, CHARLIE D.; OUK, SAMEDY; WELSBIE, DEREK; YOO, DONGWON
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 023463/0018 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 3, 2009
From: TRAN, CHRISTOPHER T., MR.; WONGVIPAT, JOHN, MR.
To: HOWARD HUGHES MEDICAL INSTITUTE
Reel/Frame 023462/0134 →
CONFIRMATORY LICENSE Recorded Aug 12, 2009
From: UNIVERSITY OF CALIFORNIA LOS ANGELES
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 023088/0469 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2009
From: HOWARD HUGHES MEDICAL INSTITUTE
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 022867/0741 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2009
From: SAWYERS, CHARLES
To: HOWARD HUGHES MEDICAL INSTITUTE
Reel/Frame 022867/0681 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT APPLICATION NUMBER PREVIOUSLY RECORDED ON REEL 022845 FRAME 0703. ASSIGNOR(S) HEREBY CONFIRMS THE APPLICATION NO. 11/433829. Recorded Jun 22, 2009
From: JUNG, MICHAEL E.; CHEN, CHARLIE D.; OUK, SAMEDY; WELSBIE, DEREK; TRAN, CHRIS; WONGVIPAT, JOHN; YOO, DONGWON
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 022857/0181 →
CORRECTIVE ASSIGNMENT TO CORRECT THE NUMBER OF ASSIGNORS TO DELETE THE FIRST ASSIGNOR, CHARLES SAWYERS, AND TO CORRECT THE EXECUTION DATES PREVIOUSLY RECORDED ON REEL 018299 FRAME 0916. ASSIGNOR(S) HEREBY CONFIRMS THE NUMBER OF ASSIGNORS AND EXECUTION DATES AS CURRENTLY PRESENTED.. Recorded Jun 18, 2009
From: JUNG, MICHAEL E.; CHEN, CHARLIE D.; OUK, SAMEDY; WELSBIE, DEREK; TRAN, CHRIS; WONGVIPAT, JOHN; YOO, DONGWON
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 022845/0703 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 13, 2006
From: SAWYERS, CHARLES L.; CHEN, CHARLIE D.; WEILSBIE, DEREK; WONGVIPAT, JOHN; JUNG, MICHAEL E.; OUK, SAMEDY; TRAN, CHRIS; YOO, DONGWON
To: REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE
Reel/Frame 018299/0916 →
Continuity (5)
Provisional Application 6068083500 · May 13, 2005
Provisional Application 6075035100 · Dec 15, 2005
Provisional Application 6075655200 · Jan 6, 2006
Provisional Application 6078683700 · Mar 29, 2006
Related Publication 20070004753A1 · Jan 4, 2007