Aqueous inhalation pharmaceutical composition
An aqueous inhalation pharmaceutical composition comprising a polypeptide or protein is provided. The composition of the present invention can improve the bioavailability of the polypeptide and protein, and avoid inducing toxicity in the lung.
1. An aqueous inhalation pharmaceutical composition for treating diabetes, consisting of:
(i) an insulin in a concentration of about 0.05 to about 20.0 mg/ml;
(ii) an aqueous vehicle;
(iii) Tween-80; and
(iv) buffer for maintaining the value of pH;
wherein said composition has an osmotic pressure of from about 270 to about 330 mOsm/kg.
2. The pharmaceutical composition according to claim 1 , wherein the aqueous vehicle is sodium chloride solution.
3. An aqueous inhalation pharmaceutical composition consisting of:
(i) an insulin in a concentration of about 0.05 to about 20.0 mg/ml;
(ii) an aqueous vehicle;
(iii) Tween-80; and
(iv) pH adjuster;
wherein said composition has an osmotic pressure of from about 270 to about 330 mOsm/kg.
4. The pharmaceutical composition according to claim 1 , which has a pH from about 7.0 to about 8.0.
5. The pharmaceutical composition according to claim 1 , wherein the amount of the insulin is from about 1.0 to about 5.0 mg/ml.
6. The pharmaceutical composition according to claim 1 , wherein the content of Tween-80 is from about 0.001 to about 10 mg/ml.
7. The pharmaceutical composition according to claim 3 , wherein the aqueous vehicle is sodium chloride solution.
8. The pharmaceutical composition according to claim 3 , which has a pH from about 7.0 to about 8.0.
9. The pharmaceutical composition according to claim 3 , wherein the amount of the insulin is from about 1.0 to about 5.0 mg/ml.
10. The pharmaceutical composition according to claim 3 , wherein the content of Tween-80 is from about 0.001 to about 10 mg/ml.