Fibrinogen-based tissue adhesive containing an elastase inhibitor

1. An isolated fibrinogen based tissue adhesive comprising fibrinogen in an amount of 50-110 mg/ml of the tissue adhesive, and an admixed elastase inhibitor, wherein said elastase inhibitor is α1-antiprotease in an amount of 0.01 U/ml to 1 U/ml of the tissue adhesive and wherein said tissue adhesive is resistant to lysis in an environment with high fibrinolytic activity for a period of time which is at least 15 hours.

2. A tissue adhesive as set forth in claim 1 , wherein said tissue adhesive is comprised of human proteins.

3. A tissue adhesive as set forth in claim 1 , further comprising plasminogen.

4. A tissue adhesive as set forth in claim 3 , further comprising plasminogen in an amount of at least 0.0001 mg/mg of fibrinogen.

5. A tissue adhesive as set forth in claim 3 , wherein said plasminogen is contained in an amount of at least 0.001 mg/mg of fibrinogen.

6. A tissue adhesive as set forth in claim 3 , wherein said plasminogen is contained in an amount of more than 0.01 mg/mg of fibrinogen.

7. A tissue adhesive as set forth in claim 1 , wherein said tissue adhesive is free from kininogenic proteins.

8. A tissue adhesive as set forth in claim 1 , wherein said tissue adhesive is lyophilized.

9. A tissue adhesive as set forth in claim 1 , wherein said tissue adhesive is present in solution.

10. A tissue adhesive as set forth in claim 9 , wherein said solution is deep-frozen.

11. A tissue adhesive as set forth in claim 1 , wherein said tissue adhesive is present in virus-inactivated form.

12. A tissue adhesive as set forth in claim 1 , wherein said elastase inhibitor is of recombinant orgin.