Compositions and methods for altering immune function
The present invention relates to molecules that stabilize and/or enhance CD154 activity, compositions comprising these molecules, methods for using these molecules and compositions (e.g., pharmaceutical compositions) comprising them. Specifically, the molecules can be used for enhancing immune function (e.g., enhancing Th1 cytokine expression), stimulating immune responses, and/or treating certain disorders (e.g., cancer, infectious disease, and immune compromised states). The invention also relates to kits and compositions comprising the molecules.
1. A method for stimulating an immune response in a vertebrate comprising administering to said vertebrate a composition comprising: i) JFPB (ethyl N-[[1-(2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]ethyl)-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl]carbamate) and/or JFPH (4-azocan-1-YL-5,7-dichloro-2-(trifluoromethyl)quinoline), and ii) an antigen.
2. The method of claim 1 , wherein said vertebrate has or is at risk of developing cancer.
3. The method of claims 1 , wherein said vertebrate is a subject having or at risk of developing an infectious disease or an infection.
4. The method of claim 3 , wherein said infection is selected from the group consisting of a bacterial infection, a viral infection, a fungal infection, a yeast infection, a mycobacterial infection, and a parasitic infection.
5. The method of claim 1 , wherein said composition is administered in an amount effective to stimulate an immune response.
6. The method of claim 5 , wherein said immune response is a cell-mediated immune response.
7. The method of claim 5 , wherein said immune response is an adaptive immune response.
8. The method of claim 5 , wherein said immune response is a Th1-type immune response.
9. The method of claim 5 , wherein said immune response is an antibody mediated immune response.
10. The method of claim 1 , wherein said composition is administered in combination with an antibody or antibody fragment.
11. The method of claim 9 , wherein said antibody or antibody fragment is specific for a cancer or cancer antigen.
12. The method of claim 9 , wherein said antibody or antibody fragment is administered in a sub-therapeutic dose.
13. The method of claim 1 , wherein said composition comprises said JFPB (ethyl N-[[1-(2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]ethyl)-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl]carbonyl]carbamate) and said antigen.
14. The method of claim 1 , wherein said composition comprises said JFPH (4-azocan-1-YL-5,7-dichloro-2-(trifluoromethyl)quinoline) and said antigen.
15. A method for stimulating an immune response in a vertebrate comprising administering to said vertebrate a composition comprising JFPH (4-azocan-1-YL-5,7-dichloro-2-(trifluoromethyl)quinoline), wherein said subject has a cancer.