Granted Patent B2

US 7,153,677 · App. 11/446,881 · Granted Dec 26, 2006

Assignee: The Board of Regents of the University of Oklahoma

Abstract

Claims (6)

1. An isolated, recombinantly produced, enzymatically active hyaluronan synthase, wherein the isolated, recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual-action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA.

2. The isolated, recombinantly produced, enzymatically active hyaluronan synthase of claim 1 , wherein the isolated, recombinantly produced, enzymatically active hyaluronan synthase is produced from a hyaluronan synthase gene isolated from a microbial source.

3. The isolated, recombinantly produced, enzymatically active hyaluronan synthase of claim 1 , wherein the isolated, recombinantly produced, enzymatically active hyaluronan synthase is produced from a hyaluronan synthase gene isolated from a streptococcal source.

4. A purified, recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual-action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA.

5. The purified, recombinantly produced, enzymatically active hyaluronan synthase of claim 4 , wherein the purified, recombinantly produced, enzymatically active hyaluronan synthase is produced from a hyaluronan synthase gene isolated from a microbial source.

6. The purified, recombinantly produced, enzymatically active hyaluronan synthase of claim 4 , wherein the purified, recombinantly produced, enzymatically active hyaluronan synthase is produced from a hyaluronan synthase gene isolated from a streptococcal source.

Assignments (1)

Continuity (8)